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triazoxide (Ref: SAS 9244)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for triazoxide

Description: A highly selective fungicide used as a seed treatment for control of barley seed-borne diseases

Example pests controlled: Barley stripe (Pyrenophora graminea); Net blotch (Pyrenophora teres)

Example applications: Barley

Efficacy & activity: -

Availability status: Unknown

Introduction & key dates: 1990

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Germant/Slovakia
Date inclusion expires 30/09/2021
EU Candidate for substitution (CfS) Yes - low ADI / ARfD / AOEL
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C10H6ClN5O
Canonical SMILES C1=CC2=C(C=C1Cl)[N+](=NC(=N2)N3C=CN=C3)[O-]
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) IQGKIPDJXCAMSM-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H6ClN5O/c11-7-1-2-8-9(5-7)16(17)14-10(13-8)15-4-3-12-6-15/h1-6H
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Benzotriazine
Minimum active substance purity 970 g/kg
Known relevant impurities EU dossier: Toluene 3g/kg
Substance origin Synthetic
Mode of action Specific, non-systemic
CAS RN 72459-58-6
EC number 276-668-4
CIPAC number 729
US EPA chemical code -
PubChem CID 93422
Molecular mass (g mol-1) 247.64
PIN (Preferred Identification Name) 7-chloro-3-(1H-imidazol-1-yl)-1,2,4-benzotriazine 1-oxide
IUPAC name 7-chloro-3-imidazol-1-yl-1,2,4-benzotriazine 1-oxide
CAS name 7-chloro-3-(1H-imidazol-1-yl)-1,2,4-benzotriazine 1-oxide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 35
Examples of recorded resistance -
Physical state Light yellow-green crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
Example products using this active -
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Formulations include flowable concentrates for seed treatment. Usually sold in mixtures with other fungicides.


ENVIRONMENTAL FATE

for triazoxide

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 34 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 32000 A5 - Dichloromethane -
50 A5 - Hexane -
6900 A5 - Toluene -
5300 A5 - Acetone -
Melting point (oC) 179 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 170 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.10 X 1002 Calculated -
Log P 2.04 A5 Low
Bulk density (g ml-1)/Specific gravity 1.58 L3 -
Dissociation constant (pKa) at 25oC No data A5 -
Note: Very weak base
Vapour pressure at 20oC (mPa) 1.00 X 10-04 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 7.30 X 10-07 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.81 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.59 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 262nm = 49400, 380nm = 5000 A5 -
Surface tension (mN m-1) 71.9 A5 at 20oC, 90% solution -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 250 A5 Persistent
DT50 (lab at 20oC) 250 A5 Persistent
DT50 (field) 110 A5 Persistent
DT90 (lab at 20oC) - - -
DT90 (field) 802 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 208-278 days, field studies DT50 range 18-99 days, DT90 range 640-1080 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 1 A5 Moderately fast
Note Data for test conditions continuous irradiation equivalent to DT50 of 3.5 solar days in Arizona, USA 33 deg N
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note pH sensitive: stable at pH 4 and pH 7, DT50 6.9 days at pH 9, all at 20 degC
Water-sediment DT50 (days) 2.9 A5 Fast
Water phase only DT50 (days) 0.5 A5 Fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 13.0 A5 Slightly mobile
Kfoc 673
1/n 0.772
Notes and range EU dossier kf range 3.64-38.8 mL/g, Kfoc range 245-1743 mL/g, 1/n range 0.747-0.787, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
7-chloro-3-(1H-imidazol-1-yl)-1,2,4-benzotriazine This metabolite may cause environmental pollution, click here for further information Soil   0.255   Major fraction, Relevant
7-chloro-1,2,4-benzotriazin-3-amine 1-oxide This metabolite may cause environmental pollution, click here for further information Soil   0.187   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
triazoxide desoxyamino triazoxide metabolite M05 Water (Photolysis); Water/sediment - -
triazoxide oxone triazoxide metabolite M04 Soil (Hydrolysis) - -


ECOTOXICOLOGY

for triazoxide

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 98 A5 Rat High
Mammals - Short term dietary NOEL (mg kg-1) 0.25 B5 Rat High
(ppm diet) 2 -
Birds - Acute LD50 (mg kg-1) 90 A5 Coturnix japonica High
Birds - Short term dietary (LC50/LD50) 849.5 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 0.077 A5 Lepomis macrochirus High
Fish - Chronic 21 day NOEC (mg l-1) 0.077 Q2 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 7.2 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.1 Q2 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 10.0 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.039 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.01 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 200 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 225 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect 500 A5 Folsomia candida, 28 day NOEC total effects -
Other arthropod (1) LR50 g ha-1 5.7 >
A5 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 5.13 >
A5 Aphidius rhopalosiphi
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.038 mg kg-1 soil; 28days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for triazoxide

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 98 A5 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 0.75 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0002 A5 Rat, SF=300 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.015 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.001 A5 Rat, SF=100 -
Dermal penetration studies (%) 2.4/2.0 A5 concentrate/grain dust -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Acceptable risks for bystanders
Occupational Acceptable risks for operators and other workers for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; Calc MAC=0.15 μg l-1; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible spleen toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
Oxidising potential
IMDG Transport Code is usually 6.1
CLP classification 2013 None allocated at this time
EC Risk Classification Click here to view information omn the EU risk phrases Reproduction risk category 3: R64
T - Toxic: R25, R23, R48
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 2811
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group I (great danger)


TRANSLATIONS

for triazoxide

Language Name
English triazoxide
French triazoxide
German Triazoxid
Danish triazoxid
Italian triazoxide
Spanish triazóxido
Greek -
Slovenian triazoksid
Polish triazoksyd
Swedish -
Hungarian -
Dutch -

Record last updated: Wednesday 30 May 2018
Contact: aeru@herts.ac.uk
© University of Hertfordshire