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trifloxystrobin (Ref: CGA 279202)
** HSDB 7276 ** Translations

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SUMMARY

Trifloxystrobin is a widely used fungicide that has EU approval for use. It has a low aqueous solubility, a low volatility and, based on its chemical properties, would not normally be expected to leach to groundwater. It would not be expected to be persistent in soil or water systems. It has a low mammalian oral toxicity but there is some evidence that it may cause negative reproduction or fertility effects. It is highly toxic to bird, fish and aquatic invertebrates, but less toxic to honeybees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for trifloxystrobin

Description: A Strobilurin foliar applied fungicide for control of certain foliar, stem and root diseases

Example pests controlled: Alternaria; Black root; Black spot; Botrytis; Downy mildew; Powdery mildew; Leaf spot; Rust; Rhizoctonia stem & root rot; Scab; Blossom blight

Example applications: Cereals; Ornamentals; Vegetables including carrots, asparagus, curcubits, fruiting vegetables, root vegetables (except radish); Fruit including apples, pears, grapes, strawberries; Tropical crops

Efficacy & activity: Wheat/Mildew=Low; Wheat/Septoria=Low; Wheat/Rust=Low; Barley/Rhynchosporium=Low; Barley/Rust=Moderate

Availability status: Current

Introduction & key dates: 1999, South Africa and USA

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK/Greece
Date inclusion expires 31/07/2033
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Exists as four geometric isomers: EE, EZ, ZE, and ZZ
Chemical formula C20H19F3N2O4
Canonical SMILES CC(=NOCC1=CC=CC=C1C(=NOC)C(=O)OC)C2=CC(=CC=C2)C(F)(F)F
Isomeric SMILES C/C(=N\OCC1=CC=CC=C1/C(=N\OC)/C(=O)OC)/C2=CC(=CC=C2)C(F)(F)F
International Chemical Identifier key (InChIKey) ONCZDRURRATYFI-TVJDWZFNSA-N
International Chemical Identifier (InChI) InChI=1S/C20H19F3N2O4/c1-13(14-8-10-16(11-9-14)20(21,22)23)24-29-12-15-6-4-5-7-17(15)18(25-28-3)19(26)27-2/h4-11H,12H2,1-3H3/b24-13+,25-18+
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Strobilurin
Minimum active substance purity 980 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Broad spectrum with preventative and curative action. Respiration inhibitor (QoL fungicide).
CAS RN 141517-21-7
EC number -
CIPAC number 617
US EPA chemical code 129112
PubChem CID 11664966
Molecular mass (g mol-1) 408.37
PIN (Preferred Identification Name) methyl (2E)-(methoxyimino)(2-{[({(1E)-1-[3-(trifluoromethyl)phenyl]ethylidene}amino)oxy]methyl}phenyl)acetate
IUPAC name methyl (E)-methoxyimino-{(E)-α-[1-(α,α,α-trifluoro-m-tolyl)ethylideneaminooxy]-o-tolyl}acetate
CAS name methyl (αE)-α-(methoxyimino)-2-(((((1E)-1-(3-(trifluoromethyl)phenyl)ethylidene)amino)oxy)methyl)benzeneacetate
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 11
Examples of recorded resistance -
Physical state White solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Bayer CropScience
  • Pan Agriculture
Example products using this active
  • Coronet
  • Jaunt
  • Nativo
  • Scorpio
  • Compass
  • Twist
  • Flint
  • Zato 50 WG
UK LERAP status None (may vary with mixtures)
Formulation and application details Often supplied as water dispersible granules that are mixed with water and used as a spray.


ENVIRONMENTAL FATE

for trifloxystrobin

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.61 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 500000 A5 - Acetone -
500000 A5 - Ethyl acetate -
76000 A5 - Methanol -
500000 A5 - Toluene -
Melting point (oC) 72.9 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 285 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 3.16 X 1004 Calculated -
Log P 4.5 A5 High
Bulk density (g ml-1)/Specific gravity 1.36 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 3.40 X 10-03 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.30 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.30 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.43 X 10-05 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 250.7nm = 17500, no absorption between 340-750nm A5 -
Surface tension (mN m-1) 65.3 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Not readily biodegradable
Soil degradation (days) (aerobic) DT50 (typical) 0.34 Click here to see a warning relating to modelling and this active substance A5 Non-persistent
DT50 (lab at 20oC) 0.34 A5 Non-persistent
DT50 (field) 1.69 A5 Non-persistent
DT90 (lab at 20oC) 39 A4 -
DT90 (field) 20.9 A5 -
DT50 modelling endpoint 0.60 A5 -
Note EU RAR 2016 lab studies DT50 range 0.13-2.83 days, Soils = 20; field study DT50 range 1.1-2.73 days, DT90 range 10.4-35.6 days, Soils=6
Dissipation rate RL50 on plant matrix Value 5.0 R4 -
Note Published literature RL50 range 1.7-7.0 days, field grown ginseng & peppers, various matrices, n=4
Dissipation rate RL50 on and in plant matrix Value 9.1 R4 -
Note Published literature RL50 range 6.4-12.0 days, fruit of field grown grapes & mango, n=3
Aqueous photolysis DT50 (days) at pH 7 Value 2.7 A5 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 40 A5 Moderately persistent
Note pH sensitive: DT50 480 days at pH 5, 40 days at pH 7, 1.2 days at pH 9, all at 25 degC
Water-sediment DT50 (days) 2.4 A5 Fast
Water phase only DT50 (days) 1.1 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 43.5 A5 Slightly mobile
Kfoc 2287
1/n 0.96
Notes and range EU dossier Kf range 11.2-325 mL/g, Koc range 1642-3745 mL/g, Soils=6
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
(E,E)-trifloxystrobin acid (Ref: CGA 321113) This metabolite may cause environmental pollution, click here for further information Soil   0.970   Major fraction, Relevant
(E)-2-((((1-(3-(trifluoromethyl)phenyl)ethylidene)amino)oxy)methy)benzonitrile (Ref: CGA 357276) Soil   0.056   Minor fraction; Relevant
(Z,E)-methoxyimino-(2-(1-(3-trifluoro methylphenyl-ethylideneaminooxymethyl)-phenyl)-acetic acid (Ref: CGA 373466) This metabolite may cause environmental pollution, click here for further information Soil   0.425   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: CGA 166988) - Poultry - -
(Ref: CGA 279202)
Note: Koc = 9513064
- Soil - -
(Ref: CGA 327262) - Soil (Photolysis) - -
(Ref: CGA 331409) - Plant; Water (Aerobic); Soil (Photolysis) - -
(Ref: CGA 357261)
Note: LD50(oral, rat) >2000 mg kg-1; Koc = 389567
- Plant; Water (Photolysis) - -
(Ref: CGA 357362) - Water (Photolysis) - -
(Ref: NOA 413161)
Note: LD50(oral, rat) >2000 mg kg-1; Risk to Groundwater
- Soil; Plant - -
(Ref: NOA 413163)
Note: LD50(oral, rat) >2000 mg kg-1
- Soil; Plant - -
(Ref: NOA 414412)
Note: LD50(oral, rat) >2000 mg kg-1
- - - -
(Ref: NOA 417076) - Poultry; Plant - -


ECOTOXICOLOGY

for trifloxystrobin

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 431 A5 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 6.4 A5 Rat High
(ppm diet) > 100 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5200 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 0.022 A5 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) 0.008 A5 Oncorhynchus mykiss High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.011 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.003 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) 0.45 A4 Chironomus riparius, EC50 Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.2 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 1.93 F3 Lemna gibba Moderate
Non-target plants > 270 A5 Brassica oleracea, Daucus carota, Lactuca sativa, Zea mays, Lolium perenne
Vegetative vigour, ER50
as g/ha
-
> 270 A5 Brassica oleracea, Daucus carota, Lactuca sativa, Zea mays, Lolium perenne
Seedling emergence, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 0.0053 A4 Scenedemus subspicatus, 72 hour High
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.01 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 110 A5 Apis mellifera Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 3.5 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 383 >
A5 Typhlodromus pyri
-
% Effect 29 Mortality/ Beneficial capacity
Dose: 0.01 kg ha-1
A4 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 500 >
A5 Aphidius colemani
-
% Effect 93 Mortality
Dose: 0.5 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.27 mg kg-1 soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for trifloxystrobin

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.5 A5 Rat, 4hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.1 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.06 A4 Rat, 2 year, SF=100 -
Dermal penetration studies (%) 1.6-3.8 A5 concentration dependent -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Probable liver & teste toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H317
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R43
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S24, S37, S46, S60, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number Variable with product, usually 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for trifloxystrobin

Language Name
English trifloxystrobin
French trifloxystrobine
German Trifloxystrobin
Danish trifloxystrobin
Italian trifloxistrobina
Spanish trifloxiestrobina
Greek -
Slovenian trifloksistrobin
Polish trifloksystrobina
Swedish trifloxystrobin
Hungarian trifloxistrobin
Dutch trifloxystrobine

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk
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