| zineb (Ref: ENT 14874) |
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SUMMARY
Zineb is a fungicide that does not have approval for use within the EU. It has a low aqueous solubility, is relatively volatile and is not expected, based on its physico-chemical propoerties, to leach to groundwater. It is not usually persistent in soil or water systems. Zineb has a low mammalian toxicity however, it may cause adverse reproduction/developement effects if ingested. It is moderately toxic to most fauna and flora. GENERAL INFORMATION 
for zineb
Description: A carbamate fungicide used on edible crops and ornamentals
Example pests controlled: Downy mildew; Foliar diseases; Damping off; Rust; Scab; Anthracnose; Leaf spot & speckle; Early & late blight; Purple blotch
Example applications: Turf; Fruit trees; Ornamentals including carnations, roses, gladioli, snapdragon; Vegetables including beans, carrots, brassicas, eggplant, onions, celery, peppers; Tobacco; Potatoes
Efficacy & activity: -
Availability status: Current
Introduction & key dates: circa 1950
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | Ireland |
| Date inclusion expires | Expired |
| EU Candidate for substitution (CfS) | Not applicable |
| Listed in EU database | Yes |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Australia
Chemical structure:
| Isomerism | None |
| Chemical formula | C4H6N2S4Zn |
| Canonical SMILES | C(CNC(=S)[S-])NC(=S)[S-].[Zn+2] |
| Isomeric SMILES | No data |
| International Chemical Identifier key (InChIKey) | AMHNZOICSMBGDH-UHFFFAOYSA-L |
| International Chemical Identifier (InChI) | InChI=1S/C4H8N2S4.Zn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2 |
| 2D structure diagram/image available? | Yes |
General status:
| Pesticide type | Fungicide | |
| Substance group | Carbamate | |
| Minimum active substance purity | - | |
| Known relevant impurities | - | |
| Substance origin | Synthetic | |
| Mode of action | Non-specific with protective action. Multi-site activity. | |
| CAS RN | 12122-67-7 | |
| EC number | 235-180-1 | |
| CIPAC number | 25 | |
| US EPA chemical code | 014506 | |
| PubChem CID | 5284484 | |
| Molecular mass (g mol-1) | 275.78 | |
| PIN (Preferred Identification Name) | zinc ethylenebis(dithiocarbamate) (polymeric) | |
| IUPAC name | zinc ethylenebis(dithiocarbamate) (polymeric) | |
| CAS name | ((2-((dithiocarboxy)amino)ethyl)carbamodithioato))(2-)-kS,kS')zinc | |
| Other status information | Chemical subject to PIC regulations | |
| Relevant Environmental Water Quality Standards | - | |
| Herbicide Resistance Classification (HRAC) | Not applicable | |
| Herbicide Resistance Classification (WSSA) | Not applicable | |
| Insecticide Resistance Classification (IRAC) | Not applicable | |
| Fungicide Resistance Classification (FRAC) | M3 | |
| Examples of recorded resistance | - | |
| Physical state | Greyish white powder | |
| Related substances & organisms | ||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | No UK approval for use as a pesticide under EC Regulation 1107/2009 | |||
| Formulation and application details | Usually supplied as a wettable powder or dust. | |||
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 10 | K4 | Low | |
| Solubility - In organic solvents at 20oC (mg l-1) | - | - | - | |
| Melting point (oC) | Decomposes before melting | L3 - | - | |
| Boiling point (oC) | Decomposes before boiling | L3 | - | |
| Degradation point (oC) | 157 | L3 | - | |
| Flashpoint (oC) | 90 | L3 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 2.00 X 1001 | Calculated | - |
| Log P | 1.3 | G4 | Low | |
| Bulk density (g ml-1)/Specific gravity | - | - | - | |
| Dissociation constant (pKa) at 25oC | Not applicable | R3 | - | |
| Note: No dissociation | ||||
| Vapour pressure at 20oC (mPa) | 0.008 | G4 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 2.76 X 10-04 | L3 | Non-volatile | |
GUS leaching potential index  |
1.48 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 2.61 X 10-02 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Medium | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 30 | M4 | Moderately persistent |
| DT50 (lab at 20oC) | - | - | - | |
| DT50 (field) | 19.5 | AC3 | Non-persistent | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | IUCLID datasheet field studies DT50 16-23 days | |||
| Dissipation rate RL50 on plant matrix | Value | 7.7 | R4 | - |
| Note | Published literature RL50 range 2.42-25.7 days, various field-grown crops/matrices, n=11 | |||
| Dissipation rate RL50 on and in plant matrix | Value | 3.4 | R3 | - |
| Note | Asparagus, whole plant, n=1 | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | Stable | Q2 | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 8.6 | K4 | Non-persistent |
| Note | - | |||
| Water-sediment DT50 (days) | 37 | K4 | Moderately fast | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | G4 | Slightly mobile |
| Koc | 1000 | |||
| Notes and range | - | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 20 | P4 | Low potential |
| CT50 (days) | Not available | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | > 5200 | L3 Rat | Low | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | - | - |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | > 2000 | G4 Anas platyrhynchos | Low | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | > 20.8 | F3 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | > 40 | J4 Daphnia magna | Moderate | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | 0.51 | F4 Scenedesmus acutus | Moderate | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | 0.05 | P3 Scenedesmus quadricauda, biomass | Moderate | |
| Honeybees (Apis spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | 13.1 | K4 | Moderate |
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Bumblebees (Bombus spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| - | ||||
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| - | ||||
| Mason bees (Osmia spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Other pollinators (1) | Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) | - | - | - |
| Mode of exposure | - | |||
| Other pollinators (2) | Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) | - | - | - |
| Mode of exposure | - | |||
| Earthworms - Acute 14 day LC50 (mg kg-1) | 960 | Q3 | Moderate | |
| Earthworms - Chronic NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms | Acute LC50 (mg kg-1) | - | - | - | Chronic NOEC (mg kg-1) | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | Harmful | AB1 Typhlodromus pyri | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for zineb
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | > 5200 | L3 Rat | Low | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | > 6000 | L3 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | 0.8 | AC4 Rat, 4 hr | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.03 | JMPR 1993 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | List II | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | - | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Genotoxic | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
|
A3; B0; C0; D0; E2 |
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- |
- |
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Thyroid, liver & kidney toxicant IARC Group 3 carcinogen |
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| Key: Genotoxicity A: Chromosome aberration (EFSA database) B: DNA damage/repair (EFSA database) C: Gene mutation (EFSA database) D: Genome mutation (EFSA database) E: Unspecified genotoxicity type (miscellaneous data source) 0: No data 1: Positive 2: Mixed/ambiguous results 3: Negative |
Key: Other : Yes, known to cause a problem  : No, known not to cause a problem  : Possibly, status not identified - : No data found |
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Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
No information available | |||
| CLP classification 2013 | Health: H317, H335 | |||
| EC Risk Classification |
Xn - Harmful: R43 Xi - Irritant: R37 |
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| EC Safety Classification |
S2, S8, S24/25, S46 | |||
| WHO Classification | U | - | Unlikely to present an acute hazard | |
| UN Number | - | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | zineb |
| French | zinêbe |
| German | Zineb |
| Danish | zineb |
| Italian | zineb |
| Spanish | zineb |
| Greek | zineb |
| Slovenian | cineb |
| Polish | zineb |
| Swedish | - |
| Hungarian | - |
| Dutch | zineb |
Record last updated: Wednesday 27 November 2019
Contact: aeru@herts.ac.uk
© University of Hertfordshire