brodifacoum (Ref: WBA 8119) ** PP581 ** BFC ** bromfenacoum ** Translations

Environmental Fate - Ecotoxicology - Human Health

GENERAL INFORMATION

Description: A coumarin rodenticide used in internal situations

Introduction: 1978

EC Directive 1107/2009 (repealing 91/414):

Status	Excluded from Annex 1
Dossier rapporteur/co-rapporteur	-
Date inclusion expires	Expired

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia, USA

General status:

Pesticide type	Rodenticide
Substance group	Hydrocoumarin
Substance origin	Synthetic
Mode of action	2nd generation anticoagulant
CAS RN	56073-10-0
EC number	259-980-5
CIPAC number	370
US EPA chemical code	112701
Chemical formula	C31H23BrO3
SMILES	C1C(CC2=CC=CC=C2C1C3=C(OC4=CC=CC=C4C3=O)O)C5=CC=C(C=C5)C6=CC=C(C=C6)Br
International Chemical Identifier (InChI)	InChI=1/C31H23BrO3/c32-24-15-13-20(14-16-24)19-9-11-21(12-10-19)23-17-22-5-1-2-6-25(22)27(18-23)29-30(33)26-7-3-4-8-28(26)35-31(29)34/h1-16,23,27,33H,17-18H2
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	523.4
IUPAC Name	3-[(1RS,3RS;1RS,3SR)-3-(4'-bromobiphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl]-4-hydroxycoumarin
CAS Name	3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzopyran-2-one
Other status information	Severe Marine Pollutant
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	Not applicable
Physical state	White powder
Related substances & organisms	-

Formulations:

Property	Value
Example manufacturers of products using this active	Sorex Syngenta Unichem Slovenia Ypsilon SA
Example products using this active	Ridak Ratimor Delicat Sorexa Checkatube
UK LERAP status	None
Formulation and application details	Usually supplied in ready-to-use bait formulations such as granules and pellets or in self-contained control devices.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		0.0038	L3	Low
Solubility - In organic solvents at 20oC (mg l-1)		6000	C4 - Ethyl acetate	-
		6000	C4 - Acetone	-
		6000	C4 - Benzene	-
		30000	C4 - Chloroform	-
Melting Point (oC)		230	L3	-
Boiling Point (oC)		Decomposes before boiling	L3	-
Degradation point (oC)		50	L3	-
Flashpoint (oC)		Not highly flammable	L3	-
Octanol-water partition coefficient at pH 7, 20oC	P	3.16 X 1008	Calculated	-
	Log P	8.5	L3	High
Bulk density (g ml-1)/Specific gravity		1.42	L3	-
Dissociation constant (pKa) at 25oC		Not applicable	L3	-
		Note: Very weak acid
Vapour pressure at 25oC (mPa)		0.13	C4	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		1.00 X 10-03	L3	Non-volatile
Henry's law constant at 20oC (dimensionless)		7.35 X 10-03	Calculated	Volatile
GUS leaching potential index		-1.35	Calculated	Low leachability
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	5.35 X 10-03	Calculated	-
	Note	Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index		-	Calculated	High
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	84	L3	Moderately persistent
	DT50 (lab at 20oC)	-	-	-
	DT50 (field)	157	F3	Persistent
	DT90 (lab at 20oC)	-	-	-
	DT90 (field)	-	-	-
	Note	Best available data
Aqueous photolysis DT50 (days) at pH 7	Value	-	-	-
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	30	C4	Moderately persistent
	Note	-
Water-Sediment DT50 (days)		-	-	-
Water phase only DT50 (days)		-	-	-

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	L3	Non-mobile
	Koc	50000
	Notes and range	Other data source: Koc 800 mL/g (US3)
Freundlich	Kf	-	-	-
	Kfoc	-
	1/n	-
	Notes and range	-
pH sensitivity		-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	-	E2 High risk	-
	CT50 (days)	Not available		-
Bioaccumulation potential		-	-	-
Mammals - Acute oral LD50 (mg kg-1)		0.4	L3 Rat	High
Mammals - Short term dietary NOEL	(mg kg-1)	-	L3 Rat	-
	(ppm diet)	0.02		-
Birds - Acute LD50 (mg kg-1)		0.31	L3 Anas platyrhynchos	High
Birds - Short term dietary (LC50/LD50)		-	-	-
Fish - Acute 96 hour LC50 (mg l-1)		0.051	L3 Oncorhynchus mykiss	High
Fish - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.98	J4 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		-	-	-
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		-	-	-
Earthworms - Acute 14 day LC50 (mg kg-1)		-	-	-
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		0.4	L3 Rat	High
Mammals - Dermal LD50 (mg kg-1 body weight)		0.3	F4 Rabbit	-
Mammals - Inhalation LC50 (mg l-1)		0.004	L3 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		-	-	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	[Low risk due to low concentrations used in baits]
	Occupational	[Demal absorption may occur]
Examples of European MRLs (mg kg-1)	Value	-
	Note	For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
	-
General human health issues		[Highly toxic], [Indirect anticoagulant - severe poisonings may lead to massive haemorrhaging]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[No information available]
EC Risk Classification		[T+ - Very toxic: R27/28], [T - Toxic: R48/24/25], [N - Dangerous for the environment: R50, R53]
EC Safety Classification		S1/2, S45, S61, S36/37, S60
WHO Classification		Ia	-	Extremely hazardous
US EPA Classification (formulation)		I	-	Danger - Highly toxic
UN Number		3027
Waste disposal & packaging		-

TRANSLATIONS