| 2,5-dichlorobenzoic acid methyl ester |
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Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for 2,5-dichlorobenzoic acid methyl ester
Description: Used in the formulation of grafting waxes used to induce callus formation of grapevine cuttings
Introduction: Not applicable
EC Regulation 1107/2009 (repealing 91/414):
| Status | Approved |
| Dossier rapporteur/co-rapporteur | Germany |
| Date inclusion expires | 31/08/2019 |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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General status:
| Pesticide type | Plant growth regulator, Fungicide | |||
| Substance group | Benzoic acid | |||
| Substance origin | Synthetic | |||
| Mode of action | Topical | |||
| CAS RN | 2905-69-3 | |||
| EC number | 220-815-7 | |||
| CIPAC number | 686 | |||
| US EPA chemical code | - | |||
| Chiral molecule | No | |||
| Chemical formula | C8H6O2Cl2 | |||
| SMILES | O=C(OC)c1cc(Cl)ccc1Cl | |||
| International Chemical Identifier key (InChIKey) | SPJQBGGHUDNAIC-UHFFFAOYSA-N | |||
| International Chemical Identifier (InChI) | InChI=1S/C8H6Cl2O2/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4H,1H3 | |||
| Structure diagram/image available? | Yes | |||
| Molecular mass (g mol-1) | 205.04 | |||
| PIN (Preferred Identification Name) | - | |||
| IUPAC name | methyl-2,5-dichlorobenzoate | |||
| CAS name | methyl-2,5-dichlorobenzoate | |||
| Other status information | - | |||
| Herbicide Resistance Classification (HRAC) | Not applicable | |||
| Herbicide Resistance Classification (WSSA) | Not applicable | |||
| Insecticide Resistance Classification (IRAC) | Not applicable | |||
| Fungicide Resistance Classification (FRAC) | Not known | |||
| Physical state | Pale yellow crystals | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active |
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| Example products using this active |
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| UK LERAP status | No UK approval for use or outside scope | |||
| Formulation and application details | Often supplied as a waxy solid for use when grafting. | |||
ENVIRONMENTAL FATE
for 2,5-dichlorobenzoic acid methyl ester
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 87.0 | A5 | Moderate | |
| Solubility - In organic solvents at 20oC (mg l-1) | 1000000 | A5 - Dichloromethane | - | |
| 1000000 | A5 - Ethyl acetate | - | ||
| 1000000 | A5 - Xylene | - | ||
| 800000 | A5 - Methanol | - | ||
| Melting point (oC) | 38.7 | A5 | - | |
| Boiling point (oC) | 250.6 | A5 | - | |
| Degradation point (oC) | 440 | A5 | - | |
| Flashpoint (oC) | Not expected to self ignite; Not highly flammable | A5 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 2.88 X 1003 | Calculated | - |
| Log P | 3.46 | A5 | High | |
| Bulk density (g ml-1)/Specific gravity | 1.36 | Q2 | - | |
| Dissociation constant (pKa) at 25oC | Not applicable | A5 | - | |
| Note: No dissociation | ||||
| Vapour pressure at 25oC (mPa) | 320000 | A5 | Volatile | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 1.63 | A5 | Moderately volatile | |
| Henry's law constant at 20oC (dimensionless) | 3.10 X 10-01 | Calculated | Volatile | |
GUS leaching potential index  |
- | - | - | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | - | - | - |
| Note | - | |||
| Potential for particle bound transport index |
- | - | - | |
| Maximum UV-vis absorption L mol-1 cm-1 | 203nm = 37769, 229nm = 11852, 276nm = 7730, 292nm = ~6000, 334nm = ~10 | A5 | - | |
| Surface tension (mN m-1) | 60 | A5 at 20oC | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Soil degradation (days) (aerobic) | DT50 (typical) | - | - | - |
| DT50 (lab at 20oC) | - | - | - | |
| DT50 (field) | - | - | - | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| Note: | - | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | - | - | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | - | - | - |
| Note | - | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | Q2 | Slightly mobile |
| Koc | 1105 | |||
| Notes and range | Estimated | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
Other known metabolites:
| Metabolite name and reference | Aliases | Formation medium / Rate | Estimated maximum occurrence fraction | Metabolising enzymes |
| 2,5-dichlorobenzoic acid | M11.7 | Rat (Urinary); Animal | - | - |
| 2,5-dichlorobenzoylglycine | M7.2 | Rat (Urinary); Animal | - | - |
| 5-hydroxy-3,6-dichloro-o-anisic acid | - | Plant | - | - |
ECOTOXICOLOGY
for 2,5-dichlorobenzoic acid methyl ester
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF | - | - | - |
| CT50 (days) | - | - | ||
| Bioaccumulation potential | - | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 1030 | A5 Rat | Moderate | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | - | - |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | - | - | - | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 14.4 | F4 Pimephales promelas | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | - | - | - | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Algae - Acute 72 hour EC50, growth (mg l-1) | - | - | - | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | - | - | - |
| Oral acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | - | - | - | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for 2,5-dichlorobenzoic acid methyl ester
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Mammals - Acute oral LD50 (mg kg-1) | 1030 | A5 Rat | Moderate | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | > 10000 | A5 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | - | - | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | None allocated | A5 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | None allocated | A5 | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | 0.1 | A5 Rat, SF=1000 | - | |
| Dermal penetration studies (%) | 100 | A3 default | - | |
| Dangerous Substances Directive 76/464 | - | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | Negligible risk to bystanders | ||
| Occupational | Negligible risks of exposure to operators and workers | |||
| Examples of European MRLs (mg kg-1) | Value | - | ||
| Note | For the EU pesticides database click here | |||
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | Respiratory tract irritant | Skin irritant | Eye irritant |
- |
- |
- |
- |
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| General human health issues | May cause anaemia Possible liver and kidney toxicant |
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: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
Not explosive or oxidising | |||
| CLP classification 2013 | - | |||
| EC Risk Classification |
Xn - Harmful: R22 Xi - Irritant: R36 |
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| EC Safety Classification |
- | |||
| WHO Classification | NL | - | Not listed | |
| US EPA Classification (formulation) | Not applicable | - | - | |
| UN Number | - | |||
| Waste disposal & packaging |
- | |||
TRANSLATIONS
for 2,5-dichlorobenzoic acid methyl ester
| Language | Name |
| English | 2,5-dichlorobenzoic acid methyl ester |
| French | 2,5-dichlorobenzoate de methyle |
| German | Methyl-2,5-dichlorbenzoat |
| Danish | - |
| Italian | - |
| Spanish | 2,5-diclorobenzoato de metilo |
| Greek | - |
| Slovenian | - |
| Polish | metyloester kwasu dichlorobenzoensowego |
| Swedish | - |
| Hungarian | - |
| Dutch | - |
Record last updated: Wednesday 01 August 2012
Contact: aeru@herts.ac.uk