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GET ADDITIONAL DATA HERE!

chlorantraniliprole (Ref: DPX E2Y45)
** rynaxypyr ** IN-E2Y45 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for chlorantraniliprole

Description: Used to control a broad spectrum of pests on a range of crops including potatoes and cotton.

Example pests controlled: Cabbage loopers; Corn borers; Armyworms; Cutworms

Example applications: Potatoes; Grapes; Cotton

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 2007

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Ireland
Date inclusion expires 30/04/2024
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Canada; USA; Australia; Korea; New Zealand; Argentina; China; Chile; Colombia; Honduras; Indonesia; Vietnam

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C18H14BrCl2N5O2
Canonical SMILES CC1=C(C(=CC(=C1)Cl)C(=O)NC)NC(=O)C2=CC(=NN2C3=C(C=CC=N3)Cl)Br
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) PSOVNZZNOMJUBI-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C18H14BrCl2N5O2/c1-9-6-10(17(27)22-2)15(12(21)7-9)24-18(28)13-8-14(19)25-26(13)16-11(20)4-3-5-23-16/h3-8H,1-2H3,(H,22,27)(H,24,28)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Anthranilic diamide
Minimum active substance purity 930 g/kg
Known relevant impurities EU dossier: acetonitrile <3 g/kg; 3-picoline <3 g/kg; methanesulfonic acid <2 g/kg
Substance origin Synthetic
Mode of action Exhibits larvicidal activity as an orally ingested toxicant by targeting and disrupting the Ca2+ balance; Ryanodine receptor (Group 28)
CAS RN 500008-45-7
EC number -
CIPAC number 794
US EPA chemical code 090100
PubChem CID 11271640
Molecular mass (g mol-1) 483.15
PIN (Preferred Identification Name) 3-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide
IUPAC name 3-bromo-4'-chloro-1-(3-chloro-2-pyridyl)-2'-methyl-6'-(methylcarbamoyl)pyrazole-5-carboxanilide
CAS name 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 28
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Fine crystalline off-white powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • DuPont
  • Syngenta
  • Scotts Company
Example products using this active
  • Acelepryn
  • Coragen
  • DuPont E2Y45 SC
  • Altacot
  • Ferterra
  • Prevathon
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as a suspension concentrate or as water dispersible granules.


ENVIRONMENTAL FATE

for chlorantraniliprole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.88 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 3446 A5 - Acetone -
1714 A5 - Methanol -
1144 A5 - Ethyl acetate -
162 A5 - o-Xylene -
Melting point (oC) 209 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 330 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 7.24 X 1002 Calculated -
Log P 2.86 A5 Moderate
Bulk density (g ml-1)/Specific gravity 1.51 R4 -
Dissociation constant (pKa) at 25oC 10.88 A5 -
Note: Very weak acid
Vapour pressure at 20oC (mPa) 6.3 X 10-09 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.2 X 10-09 R4 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 4.22 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.86 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Acidic solution: no absorption max >200nm, 290nm = 3941; [Neutral solution: no absorption max >200nm, 290nm = 4185; [Basic solution: absorption max at ~320nm, 290nm = 6082 F4 -
Surface tension (mN m-1) 72.6 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 597 A5 Very persistent
DT50 (lab at 20oC) 597 A5 Very persistent
DT50 (field) 204 A5 Persistent
DT90 (lab at 20oC) 1183 A5 -
DT90 (field) 1677 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 270-1163 days, DT90 range 742-2205 days, Field studies DT50 range 123-561 days, DT90 range 404-5628 days; Manufacturers published data gives DT50 between 3-12 months, shorter in the presence of crop cover
Dissipation rate RL50 on plant matrix Value 1.3 R3 -
Note Cauliflower curd, n=1
Dissipation rate RL50 on and in plant matrix Value 4.5 R4 -
Note Published literature RL50 range 2.2-9.9 days, 4 field grown crops, fruit & straw, n=4
Aqueous photolysis DT50 (days) at pH 7 Value 0.31 A5 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 - @ 25 DegC -
Note pH 4: stable @ 25 DegC; pH 9: unstable @ 25 DegC
Water-sediment DT50 (days) 170 A5 Slow
Water phase only DT50 (days) 23.5 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 3.18 A5 Moderately mobile
Koc 362
Notes and range EU dossier Kd range 0.803-8.88 mL/g, Koc range 244-464 mL/g, soils-5
Freundlich Kf 2.95 A5 Moderately mobile
Kfoc 301
1/n 0.95
Notes and range EU dossier Kf range 0.633-9.16 mL/g, Kfoc range 180-539 mL/g, 1/n range 0.849-1.003, Soils = 5
pH sensitivity None

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2,6-dichloro-4-methyl-11H-pyrido(2,1-beta)quinazolin-11-one (Ref: IN-ECD73) Soil   0.049   Minor fraction, Relevant
5-bromo-N-methyl-1H-pyrazole-3-carboxamide (Ref: IN-F6L99) Soil   0.021   Minor fraction, Relevant
2-(3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl)-6-chloro-8-methyl-4(3H)-quinazoline (Ref: IN-GAZ70) Soil   0.044   Minor fraction, Relevant
2-(3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl)-6-chloro-3, 8dimethyl-4(3H)-quinazolinone (Ref: IN-EQW78) Soil   0.095   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid
(Ref: IN-DBC80)
- - - -
3-bromo-1H-pyrazole-3-carboxylic acid
(Ref: IN-EVK64)
- - - -
N-(2-(aminocarbonyl_4-4chloro-6-methylphenyl)-3-bromo-1-(3-chloro-2-pyridinyl)IH-pyrazole-5-carboxamide
(Ref: IN-F9N04)
- Soil; Sediment; Water - -
2-(((3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-yl)carbonyl)amino)-5-chloro-3-methylbenzoic acid
(Ref: IN-GKQ52)
- - - -
3-bromo-N-(4-chloro020((hydroxymethyl)amino)carbonyl)-6-methylphenyl)-1-)3-chloro-2-pyridinyl)-1H-pyrazole-5-carboximide
(Ref: IN-H2H20)
- Animal - -


ECOTOXICOLOGY

for chlorantraniliprole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 15 A5 Whole fish Low potential
CT50 (days) 1.5 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 1729 mg kg-1 BW/day A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 12.0 A5 Cyprinodon variegatus Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0116 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.00447 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.0025 A5 Pseudokirchneriella subcapitata High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 2.0 A5 Lemna gibba Moderate
Non-target plants > 300 A5 Ryegrass
Vegetative vigour, ER50
as g/ha
-
> 300 A5 Ryegrass
Seedling emergence, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) > 4.0 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 4 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 104.1 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 350 A5 Eisenia foetida Low
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 750 >
A5 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 750 >
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.7 mg/kf soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for chlorantraniliprole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.1 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 1.56 A5 Mouse, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.2 A5 Mouse, SF=100 -
Dermal penetration studies (%) 1.9-4.0 A5 Concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Low risk considering proposed uses
Occupational Low risk considering proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Possible liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not oxidising or explosive
Not senstive to thermal, friction on impact shock
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for chlorantraniliprole

Language Name
English chlorantraniliprole
French -
German -
Danish -
Italian -
Spanish clorantranilipol
Greek -
Slovenian -
Polish chlorantraniliprol
Swedish -
Hungarian -
Dutch -

Record last updated: Friday 14 September 2018
Contact: aeru@herts.ac.uk