Chlorantraniliprole (Ref: DPX E2Y45)

Chlorantraniliprole (Ref: DPX E2Y45)	Last updated: 29/05/2025
(Also known as: rynaxypyr; IN-E2Y45)

SUMMARY

Chlorantraniprole is a broad-spectrum insecticide. It has a low aqueous solubility and a low volatility. It tends to be highly persistent in the environment. It is highly toxic to aquatic invertebrates, moderately toxic to birds and aquatic plants, and has a low toxicity to bees and earthworms. Chlorantraniliprole has a low oral mammalian toxicity.

Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate	Ecotoxicity	Human health
Environmental fate High alert: Persistent; GUS: High leachability	Ecotoxicity High alert: Daphnia acute ecotoxicity: High; Daphnia chronic ecotoxicity: High	Human health Moderate alert: Reproduction/development effects

GENERAL INFORMATION

Description

Used to control a broad-spectrum of pests on a range of crops including potatoes and cotton.

Example pests controlled

Cabbage loopers; Corn borers; Armyworms; Cutworms

Example applications

Potatoes; Grapes; Cotton; Rice; Vegetables including artichoke, asparagus, bulb vegetables, corn, herbs, legumes, roots and tubers

Efficacy & activity

Availability status

Current

Introduction & key dates

2007, introduced

GB regulatory status

GB COPR regulatory status

Approved

Date COPR inclusion expires

31/12/2029

GB LERAP status

Cat B

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Approved

Dossier rapporteur/co-rapporteur

Ireland

Date EC 1107/2009 inclusion expires

31/05/2027

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece
✓	✓	✓	✓	✓	✓			✓
ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
✓		✓	✓	✓	✓		✓	✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia
✓	✓	✓	✓	✓	✓		✓	✓

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway

Additional information

Also used in

Canada; USA; Australia; Korea; New Zealand; Argentina; China; Chile; Colombia; Honduras; Indonesia; Vietnam; Morocco

Chemical structure

Isomerism

None

Chemical formula

C₁₈H₁₄BrCl₂N₅O₂

Canonical SMILES

CC1=C(C(=CC(=C1)Cl)C(=O)NC)NC(=O)C2=CC(=NN2C3=C(C=CC=N3)Cl)Br

Isomeric SMILES

International Chemical Identifier key (InChIKey)

PSOVNZZNOMJUBI-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C18H14BrCl2N5O2/c1-9-6-10(17(27)22-2)15(12(21)7-9)24-18(28)13-8-14(19)25-26(13)16-11(20)4-3-5-23-16/h3-8H,1-2H3,(H,22,27)(H,24,28)

2D structure diagram/image available?

Yes

General status

Pesticide type

Insecticide

Substance groups

Diamide insecticide; Pyridylpyrazole insecticide

Minimum active substance purity

930 g kg⁻¹

Known relevant impurities

EU dossier: acetonitrile <3 g kg⁻¹; 3-picoline <3 g kg⁻¹; methanesulfonic acid <2 g kg⁻¹

Substance origin

Synthetic

Mode of action

Exhibits larvicidal activity as an orally ingested toxicant by targeting and disrupting the Ca2+ balance; Ryanodine receptor modulator.

CAS RN

500008-45-7

EC number

610-489-8

CIPAC number

794

US EPA chemical code

090100

PubChem CID

11271640

CLP index number

No data found

Molecular mass

483.15

PIN (Preferred Identification Name)

3-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

IUPAC name

3-bromo-4'-chloro-1-(3-chloro-2-pyridyl)-2'-methyl-6'-(methylcarbamoyl)pyrazole-5-carboxanilide

CAS name

3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide

Other status information

PAN listed Highly Hazardous Chemical

Relevant Environmental Water Quality Standards

Herbicide Resistance Class (HRAC MoA class)

Not applicable

Herbicide Resistance Class (WSSA MoA class)

Not applicable

Insecticide Resistance Class (IRAC MoA class)

Fungicide Resistance Class (FRAC MOA class)

Not applicable

Examples of recorded resistance

Physical state

Fine crystalline off-white powder

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

DuPont
Syngenta
Scotts Company
Kenso Corporation (M) Sdn. Bhd

Example products using this active

Acelepryn
Coragen
DuPont E2Y45 SC
Altacot
Ferterra
Prevathon
Kenso Agcare Prevaken 200 SC

Formulation and application details

Usually supplied as a suspension concentrate or as water dispersible granules

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

0.88

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

3446

Acetone

1714

Methanol

1144

Ethyl acetate

162

o-Xylene

Melting point (°C)

209

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

330

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

7.24 X 10⁰²

Calculated

Log P

2.86

Moderate

Fat solubility of residues

Solubility

Soluble

Data type

Regulatory data - observed in metabolism and farm animal feeding studies

Density (g ml⁻¹)

1.51

Dissociation constant pKa) at 25 °C

10.88

Very weak acid

Vapour pressure at 20 °C (mPa)

6.3 X 10^-09

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

3.2 X 10^-09

Non-volatile

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Acidic solution: no absorption max >200nm, 290nm = 3941
Neutral solution: no absorption max >200nm, 290nm = 4185
Basic solution: absorption max at ~320nm, 290nm = 6082

Surface tension (mN m⁻¹)

72.6

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

597

Very persistent

DT₅₀ (lab at 20 °C)

597

Very persistent

DT₅₀ (field)

204

Persistent

DT₉₀ (lab at 20 °C)

1183

Very persistent

DT₉₀ (field)

1677

DT₅₀ modelling endpoint

Note

EU dossier lab studies DT₅₀ range 270-1163 days, DT₉₀ range 742-2205 days, Field studies DT₅₀ range 123-561 days, DT₉₀ range 404-5628 days; Manufacturers published data gives DT₅₀ between 3-12 months, shorter in the presence of crop cover

Dissipation rate RL₅₀ (days) on plant matrix

Value

1.1

Note

Published literature RL₅₀ range 0.89-1.31 days, 2 field crops, n=2; RL₅₀=210 days on cabbage leaves in laboratory study.

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

5.3

Note

Published literature RL₅₀ range 2.2-12.6 days, 6 field cropss, n=8

Aqueous photolysis DT₅₀ (days) at pH 7

Value

0.31

Fast

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Stable

at 25 °C

Stable

Note

pH 4: stable at 25 °C; pH 9: unstable at 25 °C

Water-sediment DT₅₀ (days)

170

Slow

Water phase only DT₅₀ (days)

23.5

Slow

Sediment phase only DT₅₀ (days)

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

3.18

Moderately mobile

K_oc (mL g⁻¹)

362

Notes and range

EU dossier K_d range 0.803-8.88 mL g⁻¹, K_oc range 244-464 mL g⁻¹, soils-5

Freundlich

K_f (mL g⁻¹)

2.95

Moderately mobile

K_foc (mL g⁻¹)

301

¹/_n

0.95

Notes and range

EU dossier K_f range 0.633-9.16 mL g⁻¹, K_foc range 180-539 mL g⁻¹, ¹/_n range 0.849-1.003, Soils = 5

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

3.51

Calculated

High leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

6.81 X 10^-01

Calculated

Note

Potential for particle bound transport index

Medium

Calculated

Potential for loss via drain flow

Moderately mobile

Calculated

Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk

Calculated using the Atkinson method. Assumed 0.5E+06 OH/cm³, 24 hr

Below the level of concern for long-range air transport

Bio-concentration factor

BCF (l kg⁻¹)

Whole fish

Low potential

CT₅₀ (days)

1.5

Known soil metabolites

Metabolite

Major/Minor fraction

$Click here for further information on Major/Minor fraction$

Estimated maximum occurrence fraction

Notes

2-(3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl)-6-chloro-3, 8dimethyl-4(3H)-quinazolinone (Ref: IN EQW78)

Minor fraction

0.095

2,6-dichloro-4-methyl-11H-pyrido(2,1-beta)quinazolin-11-one (Ref: IN ECD73)

Minor fraction

0.049

5-bromo-N-methyl-1H-pyrazole-3-carboxamide (Ref: IN F6L99)

Minor fraction

0.022

2-(3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl)-6-chloro-8-methyl-4(3H)-quinazoline (Ref: IN GAZ70)

Minor fraction

0.044

N-(2-(aminocarbonyl_4-4chloro-6-methylphenyl)-3-bromo-1-(3-chloro-2-pyridinyl)IH-pyrazole-5-carboxamide (Ref: IN-F9N04)

Minor fraction

0.048

Known groundwater metabolites

Metabolite

EC SANCO/221/2000 relevancy

ADI (mg kg⁻¹ bodyweight day⁻¹)

WHO drinking water guidance value (μg L⁻¹ day⁻¹)

N-(2-(aminocarbonyl_4-4chloro-6-methylphenyl)-3-bromo-1-(3-chloro-2-pyridinyl)IH-pyrazole-5-carboxamide (Ref: IN-F9N04)

Relevancy unknown

2-(3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl)-6-chloro-3, 8dimethyl-4(3H)-quinazolinone (Ref: IN EQW78)

Relevancy unknown

2,6-dichloro-4-methyl-11H-pyrido(2,1-beta)quinazolin-11-one (Ref: IN ECD73)

Relevancy unknown

5-bromo-N-methyl-1H-pyrazole-3-carboxamide (Ref: IN F6L99)

Relevancy unknown

2-(3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl)-6-chloro-8-methyl-4(3H)-quinazoline (Ref: IN GAZ70)

Relevancy unknown

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid (Ref: IN-DBC80)

3-bromo-1H-pyrazole-3-carboxylic acid (Ref: IN-EVK64)

N-(2-(aminocarbonyl_4-4chloro-6-methylphenyl)-3-bromo-1-(3-chloro-2-pyridinyl)IH-pyrazole-5-carboxamide (Ref: IN-F9N04)

Sediment; Water

2-(((3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-yl)carbonyl)amino)-5-chloro-3-methylbenzoic acid (Ref: IN-GKQ52)

3-bromo-N-(4-chloro020((hydroxymethyl)amino)carbonyl)-6-methylphenyl)-1-)3-chloro-2-pyridinyl)-1H-pyrazole-5-carboximide (Ref: IN-H2H20)

Animal

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 5000

Rat

Low

Mammals - Short term dietary NOEL

(mg kg⁻¹)

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

1199

Rat Reproductive NOAEL

Low

Birds - Acute LD₅₀ (mg kg⁻¹)

> 2250

Colinus virginianus

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

> 1729 mg kg bw⁻¹ day⁻¹

Colinus virginianus

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

> 10.1

Colinus virginianus

Moderate

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

> 1000

Eisenia foetida

Low

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

350

Eisenia foetida

Low

Soil micro-organisms

Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect

Dose: 0.7 mg kg⁻¹ soil 28 Day

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

0.39

Folsomia candida

Non-target plants

> 300

Ryegrass
Vegetative vigour, ER₅₀
as g ha⁻¹

> 300

Ryegrass
Seedling emergence, ER₅₀
as g ha⁻¹

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 4.0

Apis mellifera

Moderate

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 104.1

Apis mellifera

Low

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Notes

[The residual time to 25% mortality (RT25) value for honeybees is 3 hrs - USEPA data]

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100

Bombus terrestris

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100

Bombus terrestris

Low

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

5.92

Osmia bicornis

Moderate

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds) as Mortality LR₅₀ g ha⁻¹

79.5

Coccinella septempunctata Larva

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps) as Mortality LR₅₀ g ha⁻¹

> 750

Aphidius rhopalosiphi

Beneficial insects (Predatory mites) as Mortality LR₅₀ g ha⁻¹

> 750

Typhlodromus pyri

Beneficial insects (Ground beetles)

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

> 1.09

Oncorhynchus mykiss

Moderate

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

0.11

Oncorhynchus mykiss

Moderate

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

0.0116

Daphnia magna

High

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

0.00447

Daphnia magna

High

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

0.004

Chironomus dilutus

High

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

0.0025

Chironomus riparius

High

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

0.05

Chironomus riparius

High

Aquatic plants (free-floating, growth) - Acute 7 day EC₅₀, biomass (mg l⁻¹)

> 2.0

Lemna gibba

Moderate

Aquatic plants (rooted, growth) - Acute 14 day EC₅₀, biomass (mg l⁻¹)

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

> 4.0

Pseudokirchneriella subcapitata

Moderate

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 5000

Rat

Low

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

5000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 5.1

Rat 4 hr (nose only)

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

1.56

Mouse SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

None allocated

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.36

Dermal penetration studies (%)

1.9-4.0

concentration dependent

Dangerous Substances Directive 76/464

Exposure Routes

Public

Low risk considering proposed uses

Occupational

Low risk considering proposed uses

MRLs

European

EU MRL pesticide database

Great Britain

GB MRL Register

Notes

GB MRL modified for pulses April 2021 - see UK HSE website

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Mammalian dose elimination route and rate

Rapid excretion via bile (49-53%) within 48hr of dose.

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

No data found

General human health issues

Possible liver toxicant

Handling issues

Property

Value and interpretation

General

Not oxidising or explosive
Not senstive to thermal, friction on impact shock
Not expected to auto-ignite; Not highly flammable

CLP classification 2013

Health: H319, H335
Environment: H400, H410

WHO Classification

U (Unlikely to present an acute hazard)

UN Number

Waste disposal & packaging

Shelf-life, storage, stability and reactivity

TRANSLATIONS

Language

Name

English

chlorantraniliprole

French

German

Danish

Italian

Spanish

clorantraniliprol

Greek

Polish

chlorantraniliprol

Swedish

Hungarian

Dutch

Norwegian

Record last updated:	29/05/2025
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242