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carbosulfan (Ref: OMS 3022)
** FMC 35001 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION
for carbosulfan

Description: An insecticide for control of soil dwelling and foliar pests

Example pests controlled: Rice stem borer; Millipedes; Springtails; Wireworms; Caterpillars; Flea beetles; Colarado beetles; Codling moth; Scale insects; Free-living nematodes

Example applications: Cotton; Sugarbeet; Sugarcane; Potatoes; Maize; Vegetables; Coffee; Rice

Availability status: Current

Introduction & key dates: 1979, first reported; 1982, first introduced

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Belgium
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

General status:
Pesticide type Insecticide, Nematicide
Substance group Carbamate
Minimum active substance purity 865-890 g/kg
Known relevant impurities EU dossier - Carbofuran <20 g/kg, 5-chlorocarbofuran <0.3 g/kg, N-nitrosodibutylamine <1 mg/kg
Substance origin Synthetic
Mode of action Systemic with contact and stomach action. Acetylcholine esterase inhibitor.
CAS RN 55285-14-8
EC number 259-565-9
CIPAC number 417
US EPA chemical code 090602
Chiral molecule No
Chemical formula C20H32N2O3S
SMILES c12c(CC(O2)(C)C)cccc1OC(N(SN(CCCC)CCCC)C)=O
International Chemical Identifier key (InChIKey) JLQUFIHWVLZVTJ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C20H32N2O3S/c1-6-8-13-22(14-9-7-2)26-21(5)19(23)24-17-12-10-11-16-15-20(3,4)25-18(16)17/h10-12H,6-9,13-15H2,1-5H3
Structure diagram/image available? Yes
Molecular mass (g mol-1) 380.5
PIN (Preferred Identification Name) 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl [(dibutylamino)sulfanyl]methylcarbamate
IUPAC name 2,3-dihydro-2,2-dimethylbenzofuran-7-yl (dibutylaminothio)methylcarbamate
CAS name 2,3-dihydro-2,2-dimethyl-7-benzofuranyl [(dibutylamino)thio]methylcarbamate
Other status information PAN Listed as Highly Hazardous Chemical
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Culex pipiens pipiens
Leptinotarsa decemlineata
Culex quinquefasciatus
Physical state Orange-yellow viscous liquid
Related substances & organisms

Formulations:
Property Value
Example manufacturers & suppliers of products using this active now or historically
  • Belchim
  • Fargro
  • Agrinoon Enterprise Limited
  • FMC
Example products using this active
  • Posse 10G
  • Marshal 10G
  • Advantage
UK LERAP status None
Formulation and application details Usually supplied as dry granules applied directly to soil or seed bed.


ENVIRONMENTAL FATE

for carbosulfan

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 0.11 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) Miscible A5 - Acetone -
250000 A5 - Methanol -
Miscible A5 - Toluene -
250000 A5 - Ethyl acetate -
Melting point (oC) Not applicable Q3 -
Boiling point (oC) 219.3 A5 -
Degradation point (oC) 219.5 A5 -
Flashpoint (oC) 136.7 A4 - (unstabilised) -
Octanol-water partition coefficient at pH 7, 20oC P 2.63 X 1007 Calculated -
Log P 7.42 A5 High
Bulk density (g ml-1)/Specific gravity 1.04 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 25oC (mPa) 0.0359 A5 Volatile
Henry's law constant at 25oC (Pa m3 mol-1) 0.124 A5 Moderately volatile
Henry's law constant at 20oC (dimensionless) 1.83 X 10-05 Q2 Moderately volatile
GUS leaching potential index 0.99 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 1.90 X 10-02 Calculated -
Note -
Potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 In acetonitrile: 200nm = 43420, 277.5nm = 3144; [In acetonitrile:water (50:50): 292nm = 274 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 21 A5 Non-persistent
DT50 (lab at 20oC) 29.2 A5 Non-persistent
DT50 (field) 21 A5 Non-persistent
DT90 (lab at 20oC) 740 A3 -
DT90 (field) - - -
Note EU dossier Lab studies DT50 range 9.5-19.4 d, DT90 range 14.52-1465 days; field studies DT50 range 0.35-71.9 d
Plant matrix DT50 (days) Value 3.7 R4 -
Note DT50 range 1.7 - 9.5 days, 6 plants/crops, various matrices
Aqueous photolysis DT50 (days) at pH 7 Value 0.6 A5 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 0.5 A5 Non-persistent
Note pH sensitive: DT50 0.2 hours at pH 5, 7.2 days at pH 9, 20 degC
Water-sediment DT50 (days) 4.8 A5 Fast
Water phase only DT50 (days) 1.6 A5 Moderately fast

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 52.5 A5 Slightly mobile
Kfoc 2113
1/n 1.00
Notes and range EU dossier Kf range 40.69-75.32, Kfoc range 1644-2652 mL/g, 1/n range 0.96-1.04, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy
carbofuran (Ref: OMS 864) Soil   0.880   Major fraction, Relevant
3-ketocarbofuran Soil   0.066   Relevant
dibutylamine Soil   0.215   Major, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2,3-dihydro-2,2-dimethyl-3,7-benzofurandiol 3-hydroxy-7-phenol Plant - -
2,3.dihydro-2,2-diemethyl-7-benzofuranol
(Ref: NIA 10272 )
Note: Major, Relevant
carbofuran-7-phenol Water/sediment; Plant - -


ECOTOXICOLOGY

for carbosulfan

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF (l kg-1) 990 A5 Whole fish Threshold for concern
CT50 (days) 0.09 -
Mammals - Acute oral LD50 (mg kg-1) 101 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 1.2 A5 Rat High
(ppm diet) 20 -
Birds - Acute LD50 (mg kg-1) 10 A5 Anas platyrhynchos High
Birds - Short term dietary (LC50/LD50) 3.99 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 0.015 A5 Lepomis macrochirus High
Fish - Chronic 21 day NOEC (mg l-1) 0.003 A4 Oncorhynchus mykiss, 14 day High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0015 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0032 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 47 A5 Raphidocelis subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.18 A5 High
Oral acute 48 hour LD50 (μg bee-1) 1.04 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 4.8 C3 Lumbricus terrestris High
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.12 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 96 Mortality
Dose: 0.12 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for carbosulfan

General:
Property Value Source/Quality Score/Other Information Interpretation
Threshold of Toxicological Concern (Cramer Class) High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 101 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 3700 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.61 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
Dermal penetration studies (%) 0.2 A5 as formulation -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Impurites - N-nitrosodibutylamine - may be carcinogenic

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General Not explosive or oxidising
Tackle fires with foam, carbon dioxide or dry chemical methods
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H301, H317, H330
Environment: H400, H410
EC Risk Classification T+ - Very toxic: R26
T - Toxic: R25
Xn - Harmful: R43
N - Dangerous for the environment: R50, R53
EC Safety Classification S1/2, S28, S36/37, S38, S45, S60, S61, S63
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number 2992
Waste disposal & packaging Packaging Group III (minor danger)


TRANSLATIONS

for carbosulfan

Language Name
English carbosulfan
French carbosulfan
German Carbosulfan
Danish carbosulfan
Italian carbosulfan
Spanish carbosulfan
Greek -
Slovenian karbosulfan
Polish karbosulfan
Swedish karbosulfan
Hungarian karboszulfan
Dutch -

Record last updated: Saturday 13 August 2016
Contact: aeru@herts.ac.uk