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carbosulfan (Ref: OMS 3022)
** FMC 35001 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for carbosulfan

Description: An insecticide for control of soil dwelling and foliar pests

Example pests controlled: Rice stem borer; Millipedes; Springtails; Wireworms; Caterpillars; Flea beetles; Colarado beetles; Codling moth; Scale insects; Free-living nematodes

Example applications: Cotton; Sugarbeet; Sugarcane; Potatoes; Maize; Vegetables; Coffee; Rice

Availability status: Current

Introduction & key dates: 1979, first reported; 1982, first introduced

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Belgium
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Nematicide
Substance group Carbamate
Minimum active substance purity 865-890 g/kg
Known relevant impurities EU dossier - Carbofuran <20 g/kg, 5-chlorocarbofuran <0.3 g/kg, N-nitrosodibutylamine <1 mg/kg
Substance origin Synthetic
Mode of action Systemic with contact and stomach action. Acetylcholine esterase inhibitor.
CAS RN 55285-14-8
EC number 259-565-9
CIPAC number 417
US EPA chemical code 090602
Chiral molecule No
Chemical formula C20H32N2O3S
SMILES c12c(CC(O2)(C)C)cccc1OC(N(SN(CCCC)CCCC)C)=O
International Chemical Identifier key (InChIKey) JLQUFIHWVLZVTJ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C20H32N2O3S/c1-6-8-13-22(14-9-7-2)26-21(5)19(23)24-17-12-10-11-16-15-20(3,4)25-18(16)17/h10-12H,6-9,13-15H2,1-5H3
Structure diagram/image available? Yes
Molecular mass (g mol-1) 380.5
PIN (Preferred Identification Name) 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl [(dibutylamino)sulfanyl]methylcarbamate
IUPAC name 2,3-dihydro-2,2-dimethylbenzofuran-7-yl (dibutylaminothio)methylcarbamate
CAS name 2,3-dihydro-2,2-dimethyl-7-benzofuranyl [(dibutylamino)thio]methylcarbamate
Other status information PAN Listed as Highly Hazardous Chemical
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Culex pipiens pipiens
Leptinotarsa decemlineata
Culex quinquefasciatus
Physical state Orange-yellow viscous liquid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Belchim
  • Fargro
  • Agrinoon Enterprise Limited
  • FMC
Example products using this active
  • Posse 10G
  • Marshal 10G
  • Advantage
UK LERAP status None
Formulation and application details Usually supplied as dry granules applied directly to soil or seed bed.


ENVIRONMENTAL FATE

for carbosulfan

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.11 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) Miscible A5 - Acetone -
250000 A5 - Methanol -
Miscible A5 - Toluene -
250000 A5 - Ethyl acetate -
Melting point (oC) Not applicable Q3 -
Boiling point (oC) 219.3 A5 -
Degradation point (oC) 219.5 A5 -
Flashpoint (oC) 136.7 A4 - (unstabilised) -
Octanol-water partition coefficient at pH 7, 20oC P 2.63 X 1007 Calculated -
Log P 7.42 A5 High
Bulk density (g ml-1)/Specific gravity 1.04 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 25oC (mPa) 0.0359 A5 Volatile
Henry's law constant at 25oC (Pa m3 mol-1) 0.124 A5 Moderately volatile
Henry's law constant at 20oC (dimensionless) 1.83 X 10-05 Q2 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.99 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.90 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 In acetonitrile: 200nm = 43420, 277.5nm = 3144; [In acetonitrile:water (50:50): 292nm = 274 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
Soil degradation (days) (aerobic) DT50 (typical) 21 A5 Non-persistent
DT50 (lab at 20oC) 29.2 A5 Non-persistent
DT50 (field) 21 A5 Non-persistent
DT90 (lab at 20oC) 740 A3 -
DT90 (field) - - -
Note EU dossier Lab studies DT50 range 9.5-19.4 d, DT90 range 14.52-1465 days; field studies DT50 range 0.35-71.9 d
Plant matrix DT50 (days) Value 3.7 R4 -
Note DT50 range 1.7 - 9.5 days, 6 plants/crops, various matrices
Aqueous photolysis DT50 (days) at pH 7 Value 0.6 A5 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 0.5 A5 Non-persistent
Note pH sensitive: DT50 0.2 hours at pH 5, 7.2 days at pH 9, 20 degC
Water-sediment DT50 (days) 4.8 A5 Fast
Water phase only DT50 (days) 1.6 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 52.5 A5 Slightly mobile
Kfoc 2113
1/n 1.00
Notes and range EU dossier Kf range 40.69-75.32, Kfoc range 1644-2652 mL/g, 1/n range 0.96-1.04, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy Click here for further information on 91/414 relevancy
carbofuran (Ref: OMS 864) This metabolite may cause environmental pollution, click here for further information Soil   0.880   Major fraction, Relevant
3-ketocarbofuran Soil   0.066   Relevant
dibutylamine This metabolite may cause environmental pollution, click here for further information Soil   0.215   Major, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2,3-dihydro-2,2-dimethyl-3,7-benzofurandiol 3-hydroxy-7-phenol Plant - -
2,3.dihydro-2,2-diemethyl-7-benzofuranol
(Ref: NIA 10272 )
Note: Major, Relevant
carbofuran-7-phenol Water/sediment; Plant - -


ECOTOXICOLOGY

for carbosulfan

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 990 A5 Whole fish Threshold for concern
CT50 (days) 0.09 -
Mammals - Acute oral LD50 (mg kg-1) 101 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 1.2 A5 Rat High
(ppm diet) 20 -
Birds - Acute LD50 (mg kg-1) 10 A5 Anas platyrhynchos High
Birds - Short term dietary (LC50/LD50) 3.99 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 0.015 A5 Lepomis macrochirus High
Fish - Chronic 21 day NOEC (mg l-1) 0.003 A4 Oncorhynchus mykiss, 14 day High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0015 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0032 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 47 A5 Raphidocelis subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.18 A5 High
Oral acute 48 hour LD50 (μg bee-1) 1.04 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 4.8 C3 Lumbricus terrestris High
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.12 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 96 Mortality
Dose: 0.12 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for carbosulfan

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 101 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 3700 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.61 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
Dermal penetration studies (%) 0.2 A5 as formulation -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Impurites - N-nitrosodibutylamine - may be carcinogenic

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
Tackle fires with foam, carbon dioxide or dry chemical methods
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H301, H317, H330
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T+ - Very toxic: R26
T - Toxic: R25
Xn - Harmful: R43
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S28, S36/37, S38, S45, S60, S61, S63
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number 2992
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for carbosulfan

Language Name
English carbosulfan
French carbosulfan
German Carbosulfan
Danish carbosulfan
Italian carbosulfan
Spanish carbosulfan
Greek -
Slovenian karbosulfan
Polish karbosulfan
Swedish karbosulfan
Hungarian karboszulfan
Dutch -

Record last updated: Saturday 13 August 2016
Contact: aeru@herts.ac.uk