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carbosulfan (Ref: OMS 3022)
** FMC 35001 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION
for carbosulfan

Description: An insecticide for control of soil dwelling and foliar pests

Introduction: 1979, first reported; 1982, first introduced

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Belgium
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia

General status:
Pesticide type Insecticide, Nematicide
Substance group Carbamate
Substance origin Synthetic
Mode of action Systemic with contact and stomach action. Acetylcholine esterase inhibitor.
CAS RN 55285-14-8
EC number 259-565-9
CIPAC number 417
US EPA chemical code 090602
Chiral molecule No
Chemical formula C20H32N2O3S
SMILES c12c(CC(O2)(C)C)cccc1OC(N(SN(CCCC)CCCC)C)=O
International Chemical Identifier (InChI) InChI=1/C20H32N2O3S/c1-6-8-13-22(14-9-7-2)26-21(5)19(23)24-17-12-10-11-16-15-20(3,4)25-18(16)17/h10-12H,6-9,13-15H2,1-5H3
Structure diagram/image available? Yes
Molecular mass (g mol-1) 380.5
PIN (Preferred Identification Name) 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl [(dibutylamino)sulfanyl]methylcarbamate
IUPAC name 2,3-dihydro-2,2-dimethylbenzofuran-7-yl (dibutylaminothio)methylcarbamate
CAS name 2,3-dihydro-2,2-dimethyl-7-benzofuranyl [(dibutylamino)thio]methylcarbamate
Other status information -
Herbicide Resistance Classification (HRAC) Not applicable
Insecticide Resistance Classification (IRAC) 1A
Fungicide Resistance Classification (FRAC) Not applicable
Physical state Orange-yellow viscous liquid
Related substances & organisms

Formulations:
Property Value
Example manufacturers of products using this active
  • Belchim
  • Fargro
  • Agrinoon Enterprise Limited
Example products using this active
  • Posse 10G
  • Marshal 10G
  • Advantage
UK LERAP status None
Formulation and application details Usually supplied as dry granules applied directly to soil or seed bed.


ENVIRONMENTAL FATE

for carbosulfan

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 0.11 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) Miscible A5 - Acetone -
250000 A5 - Methanol -
Miscible A5 - Toluene -
250000 A5 - Ethyl acetate -
Melting point (oC) Not applicable Q3 -
Boiling point (oC) 219.3 A5 -
Degradation point (oC) 219.5 A5 -
Flashpoint (oC) 136.7 A4 - (unstabilised) -
Octanol-water partition coefficient at pH 7, 20oC P 2.63 X 1007 Calculated -
Log P 7.42 A5 High
Bulk density (g ml-1)/Specific gravity 1.04 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 25oC (mPa) 0.0359 A5 Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1) 0.124 A5 Moderately volatile
Henry's law constant at 20oC (dimensionless) 1.83 X 10-05 Q2 Moderately volatile
GUS leaching potential index 0.89 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 1.90 X 10-02 Calculated -
Note -
Potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 In acetonitrile: 200nm = 43420, 277.5nm = 3144; [In acetonitrile:water (50:50): 292nm = 274 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 21 A5 Non-persistent
DT50 (lab at 20oC) 29.2 A5 Non-persistent
DT50 (field) 21 A5 Non-persistent
DT90 (lab at 20oC) 740 A3 -
DT90 (field) - - -
Note EU dossier Lab studies DT50 range 9.5-19.4 d, DT90 range 14.52-1465 days; field studies DT50 range 0.35-71.9 d
Aqueous photolysis DT50 (days) at pH 7 Value 0.6 A5 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 0.5 A5 Non-persistent
Note pH sensitive: DT50 0.2 hours at pH 5, 7.2 days at pH 9, 20 degC
Water-Sediment DT50 (days) 4.8 A5 Fast
Water phase only DT50 (days) 1.6 A5 Moderately fast

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 52.5 A5 Slightly mobile
Kfoc 2113
1/n 1.00
Notes and range EU dossier Kf range 40.69-75.32, Kfoc range 1644-2652 mL/g, 1/n range 0.96-1.04, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy
carbofuran (Ref: OMS 864) Soil   0.880   Major fraction, Relevant
3-ketocarbofuran Soil   0.066   Relevant
dibutylamine Soil   0.215   Major, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2,3-dihydro-2,2-dimethyl-3,7-benzofurandiol 3-hydroxy-7-phenol Plant - -
2,3.dihydro-2,2-diemethyl-7-benzofuranol
(Ref: NIA 10272 )
carbofuran-7-phenol Water/sediment; Plant - -


ECOTOXICOLOGY

for carbosulfan

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF 990 A5 Whole fish Threshold for concern
CT50 (days) 0.09 -
Bioaccumulation potential - Calculated Moderate
Mammals - Acute oral LD50 (mg kg-1) 101 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 1.2 A5 Rat High
(ppm diet) 20 -
Birds - Acute LD50 (mg kg-1) 10 A5 Anas platyrhynchos High
Birds - Short term dietary (LC50/LD50) 3.99 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 0.015 A5 Lepomis macrochirus High
Fish - Chronic 21 day NOEC (mg l-1) 0.003 A4 Oncorhynchus mykiss, 14 day -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0015 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0032 A5 Daphnia magna -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Algae - Acute 72 hour EC50, growth (mg l-1) 47 A5 Raphidocelis subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees - Acute 48 hour LD50 (μg bee-1) 0.18 A5 Oral High
Earthworms - Acute 14 day LC50 (mg kg-1) 4.8 C3 Lumbricus terrestris High
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.12 kg ha-1
A5 Aphidius rhopalosiphi, adult
Harmful
Other arthropod (2) LR50 g ha-1 - - -
% Effect 96 Mortality
Dose: 0.12 kg ha-1
A5 Typhlodromus pyri, protonymph
Harmful
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for carbosulfan

General:
Property Value Source/Quality Score/Other Information Interpretation
Mammals - Acute oral LD50 (mg kg-1) 101 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 3700 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.61 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
Dermal penetration studies (%) 0.2 A5 as formulation -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
Examples of European MRLs (mg kg-1) Value Carrots: 0.1; Other vegetables, fruit and cereal grains: 0.05
Note Current May 2007.
For the EU pesticides database click here
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant Respiratory tract irritant Skin irritant Eye irritant

-

General human health issues Skin sensitiser
Impurites - N-nitrosodibutylamine - may be carcinogenic

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General Not explosive or oxidising
Tackle fires with foam, carbon dioxide or dry chemical methods
IMDG Transport Code is usually 6.1
CLP classification 2013 -
EC Risk Classification T+ - Very toxic: R26
T - Toxic: R25
Xn - Harmful: R43
N - Dangerous for the environment: R50, R53
EC Safety Classification S1/2, S28, S36/37, S38, S45, S60, S61, S63
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number 2992
Waste disposal & packaging Packaging Group III (minor danger)


TRANSLATIONS

for carbosulfan

Language Name
English carbosulfan
French carbosulfan
German Carbosulfan
Danish carbosulfan
Italian carbosulfan
Spanish carbosulfan
Greek -
Slovenian karbosulfan
Polish karbosulfan
Swedish karbosulfan
Hungarian karboszulfan
Dutch -

Record last updated: Monday 30 June 2014
Contact: aeru@herts.ac.uk