| bromobutide (Ref: S 4347 ) |
 |
Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for bromobutide
Description: A novel selective, post emeregnce herbicide that is currently used to control perennial weeds in paddy fields
Example pests controlled: Cockspur (Echinochloa oryzicola); False pickerelweed (Monochoria vaginals); Rotala indica; Scirpus juncoides
Example applications: Paddy rice
Availability status: Current
Introduction & key dates: 1981, first reported
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not listed |
| Dossier rapporteur/co-rapporteur | Not applicable |
| Date inclusion expires | Not applicable |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Japan
General status:
| Pesticide type | Herbicide | |
| Substance group | Amide | |
| Minimum active substance purity | - | |
| Known relevant impurities | - | |
| Substance origin | Synthetic | |
| Mode of action | Inhibition of 4-hydroxyphenyl-pyruvate dioxygenase, bleaching | |
| CAS RN | 74712-19-9 | |
| EC number | - | |
| CIPAC number | - | |
| US EPA chemical code | - | |
| Chiral molecule | Chiral, a specific isomer or a derivative of a chiral molecule | |
| Chemical formula | C15H22BrNO | |
| SMILES | c1(C(NC([C@@H](C(C)(C)C)Br)=O)(C)C)ccccc1 | |
| International Chemical Identifier key (InChIKey) | WZDDLAZXUYIVMU-UHFFFAOYSA-N | |
| International Chemical Identifier (InChI) | InChI=1S/C15H22BrNO/c1-14(2,3)12(16)13(18)17-15(4,5)11-9-7-6-8-10-11/h6-10,12H,1-5H3,(H,17,18) | |
| Structure diagram/image available? | Yes | |
| Molecular mass (g mol-1) | 312.25 | |
| PIN (Preferred Identification Name) | rac-(2R)-2-bromo-3,3-dimethyl-N-(2-phenylpropan-2-yl)butanamide | |
| IUPAC name | (RS)-2-bromo-3,3-dimethyl-N-(1-methyl-1-phenylethyl)butyramide | |
| CAS name | 2-bromo-3,3-dimethyl-N-(1-methyl-1-phenylethyl)butanamide | |
| Other status information | - | |
| Herbicide Resistance Classification (HRAC) | K3 (Z) | |
| Herbicide Resistance Classification (WSSA) | - | |
| Insecticide Resistance Classification (IRAC) | Not applicable | |
| Fungicide Resistance Classification (FRAC) | Not applicable | |
| Examples of recorded resistance | - | |
| Physical state | Colourless to yellow crystals | |
| Related substances & organisms | ||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | No UK approval for use or outside scope | |||
| Formulation and application details | - | |||
ENVIRONMENTAL FATE
for bromobutide
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 3.54 | E3 - @ 25 DegC | Low | |
| Solubility - In organic solvents at 20oC (mg l-1) | 4700 | E3 - Xylene | - | |
| 35000 | E3 - Methanol | - | ||
| 500 | E3 - Hexane | - | ||
| Melting point (oC) | -112 | E3 | - | |
| Boiling point (oC) | 101.4 | E3 | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | 23 | E3 - (closed cup) | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 3.02 X 1003 | Calculated | - |
| Log P | 3.48 | V3 | High | |
| Bulk density (g ml-1)/Specific gravity | 1.276 | E3 | - | |
| Dissociation constant (pKa) at 25oC | - | - | - | |
| Note: | ||||
| Vapour pressure at 25oC (mPa) | 74.0 | E3 | Highly volatile | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 6.53 | E3 | Moderately volatile | |
| Henry's law constant at 20oC (dimensionless) | 2.68 X 10-03 | Calculated | Volatile | |
GUS leaching potential index  |
- | - | - | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | - | - | - |
| Note | - | |||
| Potential for particle bound transport index |
- | - | - | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Soil degradation (days) (aerobic) | DT50 (typical) | - | - | - |
| DT50 (lab at 20oC) | - | - | - | |
| DT50 (field) | - | - | - | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| Note: | - | |||
| Plant matrix DT50 (days) | Value | - | - | - |
| Note | - | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | - | - | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | - | - | - |
| Note | - | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | - | - |
| Koc | - | |||
| Notes and range | - | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | - | - | - |
| CT50 (days) | - | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | > 5000 | E3 Rat | Low | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | - | - |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | - | - | - | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | > 10.0 | E3 Cyprinus carpio | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | - | - | - | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | - | - | - | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | - | - | - |
| Oral acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | - | - | - | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for bromobutide
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | > 5000 | E3 Rat | Low | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | > 5000 | E3 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | - | - | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | - | - | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | - | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | - | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
- |
- |
- |
- |
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- |
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
- |
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- |
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| General human health issues | May cause damage to lungs and mucous membranes | |||||||
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
Flammable | |||
| CLP classification 2013 | - | |||
| EC Risk Classification |
Xi - Irritant: R36/38 H - Handling risks: R10 |
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| EC Safety Classification |
- | |||
| WHO Classification | U | - | Unlikely to present an acute hazard | |
| US EPA Classification (formulation) | - | - | ||
| UN Number | 1126 | |||
| Waste disposal & packaging |
Packaging group II (moderate danger) | |||
| Language | Name |
| English | bromobutide |
| French | - |
| German | - |
| Danish | - |
| Italian | - |
| Spanish | - |
| Greek | - |
| Slovenian | - |
| Polish | - |
| Swedish | - |
| Hungarian | - |
| Dutch | - |
Record last updated: Wednesday 30 December 2015
Contact: aeru@herts.ac.uk