1,4-dioxane
Last updated: 19/05/2021
(Also known as: dioxane; diethylene dioxide; 1,4-diethylene dioxide; diethylene ether; glycol ethylene ether)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Primarily used as a solvent for the manufacturing sector but it is also found in fumigants and used as an automotive coolant.
-
-
Not applicable
Not applicable
Not applicable
EC Regulation 1107/2009 (repealing 91/414)
Not applicable
Not applicable
Not applicable
Not applicable
No
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
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C₄H₈O₂
C1COCCO1
No data
RYHBNJHYFVUHQT-UHFFFAOYSA-N
InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
Yes
Other substance
Solvent, Fumigant, Foaming agent
Cyclic ether
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-
Synthetic
Not applicable
123-91-1
204-661-8
-
-
-
88.11
-
1,4-dioxane
1,4-dioxane
Groundwater pollutant
-
Not applicable
Not applicable
Not applicable
Not applicable
-
Colourless, clear liquid
Miscible
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Miscible
Miscible
Acetone
-
Miscible
Methanol
-
Miscible
Ethanol
-
Miscible
n-Octanol
-
11.8
-
101.1
P3 P = Other governments and regulators 3 = Unverified data of known source
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-
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-
18.3
(open cup)
-
5.37 X 10-01
Calculated
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-0.27
Low
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-
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1.034
P3 P = Other governments and regulators 3 = Unverified data of known source
-
-2.92
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-
-
-
-
-
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-
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-
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Soil adsorption and mobility
-
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Mobile
29
Koc for clay soil
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Cannot be calculated
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-
Known soil and groundwater metabolites
None
beta-hydroxyethoxyacetic acid
HEAA
Animal
-
-
Terrestrial ecotoxicology
> 7120
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Low
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> 3494
Lepomis macrochirus
Low
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-
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> 8450
Daphnia magna
Low
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-
-
-
-
-
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-
-
-
-
-
-
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-
-
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-
3200
Chlorococcales
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 7120
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Low
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EU MRL pesticide database 
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Carcinogen
Endocrine disruptor
✓Yes, known to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Liver and kidney toxicant Over exposure may cause corneal injury
Flammable and potentially explosive Hygroscopic Corrosive
-
None - not a ppp
1165
Packaging Group II (medium danger)
1,4-dioxane
1,4-dioxanne
1,4-Dioxan
-
1,4-diossano
-
-
dioksan
-
-
1,4-dioxaan
Record last updated:
19/05/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242