Climbazole (Ref: 106162) |
![]() Last updated: 05/01/2021 |
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(Also known as: P64; BAy MEB 6401) |
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A topically applied antifungal agent and as a preservative in some personal care products. No known agricultural uses. | |
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Fungal and bacterial infections including dandruff; Fungi & mould formation | |
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Human skin; Household items; Buildings | |
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Obsolete | |
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PAN listed Highly Hazardous Chemical |
UK regulatory status |
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Not applicable | ||
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Not applicable | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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Chemical structure |
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Climbazole is a chiral molecule. The etchnical material is an isomeric mixture of the R- and S-forms. | |
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C₁₅H₁₇ClN₂O₂ | |
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CC(C)(C)C(=O)C(N1C=CN=C1)OC2=CC=C(C=C2)Cl | |
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No data | |
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OWEGWHBOCFMBLP-UHFFFAOYSA-N | |
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InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3 | |
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Yes |
General status |
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Fungicide, Other substance | |
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Preservative, Biocide | |
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Conazole | |
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>95% | |
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Various reported - chlorophenol, xylenes, hexane, cyclohexane, octane | |
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Synthetic | |
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Systemic with protective and curative action. Sterol demethylation inhibitor. | |
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38083-17-9 | |
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253-775-4 | |
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37907 | |
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292.76 | |
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rac-(1R)-1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one | |
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(RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one | |
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1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3 dimethylbutan-2-one | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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Solid powdery substance, white to pale brown in colour | |
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Formulations |
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8.28 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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Miscible | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Isopropanol5 = Verified data used for regulatory purposes |
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Miscible | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Cyclohexane5 = Verified data used for regulatory purposes |
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550 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Benzyl alcohol5 = Verified data used for regulatory purposes |
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96.8 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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412 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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212 | Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
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5.75 X 1003 | Calculated | - | |||||||
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3.76 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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0.76 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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7.5 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Max at 276nm and 283nm | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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300 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Persistent | |||||||
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Reported to be persistent especially in bio-solid amended soils | ||||||||||
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Soil adsorption and mobility |
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- | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Non-mobile | |||||||
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5754 | ||||||||||
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Calculated | ||||||||||
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Fate indices |
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0.59 | Calculated | Low leachability | ||||||||||||||||||||||||||
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1.18 X 10-02 | Calculated | - | |||||||||||||||||||||||||
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High | Calculated | - | ||||||||||||||||||||||||||
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Non-mobile | Calculated | - |
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Low risk | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Low risk | |||||||
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Not available | - | |||||||||
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400 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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15.0 | E3 E = Manufacturers safety data sheets Salvelinus confluentus3 = Unverified data of known source |
Moderate | ||||||||
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1.0 | Q2 Q = Miscellaneous internet resources 2 = Unverified data of unknown source |
Moderate | |||||||
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General |
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High (class III) | - | - | ||||||||
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400 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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5000 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rat3 = Unverified data of known source |
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Health issues |
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May cause hyperventilation and/or low blood pressure Harmful if swallowed Risk of serious damage to eyes |
Handling issues |
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IMDG Transport Code is usually 9 | |||
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Xn - Harmful: R22 N - Dangerous for the environment: R50, R52 |
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S22 | |||
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NL (Not listed) | |||
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3077 | |||
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Packaging Group III (minor danger) |
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climbazole | ||
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climbazole | ||
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climbazol | ||
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Record last updated: | 05/01/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |