Benzovindiflupyr

Benzovindiflupyr	Last updated: 12/01/2021
(Also known as: Solatenol)

GENERAL INFORMATION

Description

A novel fungicide active agaist a range of fungal diseases on cereals and other crops

Example pests controlled

Apple scab; Botrytis; Anthracnose; Sooty blotch; Fly speck; Powdery mildew

Example applications

Cereals inc wheat, rye, barley, oats; Corn; Cucurbit and fruiting vegetables; Grapes; Peanuts; Pome fruit; Potatoes; Soybeans; Sugarcane

Efficacy & activity

Efficiacy demonstrated during European field trials

Availability status

Current

Introduction & key dates

2013

UK regulatory status

UK COPR regulatory status

Approved

Date COPR inclusion expires

02/03/2026

UK LERAP status

Crop over 5m DRT - See Authorisation for Crop LERAP Details

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Approved

Dossier rapporteur/co-rapporteur

France/Austria

Date EC 1107/2009 inclusion expires

02/03/2023

EU Candidate for substitution (CfS)

Yes - two 'Persistent-Bioaccumulative-Toxic' criteria

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece
✓	✓			✓	✓		✓
ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
✓	✓	✓	✓	✓	✓	✓	✓	✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia
✓		✓	✓		✓	✓	✓	✓

Also used in

Chemical structure

Isomerism

Isomeric

Chemical formula

C₁₈H₁₅Cl₂F₂N₃O

Canonical SMILES

CN1C=C(C(=N1)C(F)F)C(=O)NC2=CC=CC3=C2C4CCC3C4=C(Cl)Cl

Isomeric SMILES

No data

International Chemical Identifier key (InChIKey)

CCCGEKHKTPTUHJ-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C18H15Cl2F2N3O/c1-25-7-11(15(24-25)17(21)22)18(26)23-12-4-2-3-8-9-5-6-10(13(8)12)14(9)16(19)20/h2-4,7,9-10,17H,5-6H2,1H3,(H,23,26)

2D structure diagram/image available?

Yes

Cambridge Crystallographic Data Centre diagrams

Common Name	Relationship	Link
benzovindiflupyr	-

General status

Pesticide type

Fungicide

Substance group

Amide

Minimum active substance purity

[EU 2015 dossier: None declared]

Known relevant impurities

Substance origin

Synthetic

Mode of action

Inhibits mitochondrial functions - Succinate Dehydrogenase Inhibitor (SDHI)

CAS RN

1072957-71-1

EC number

CIPAC number

US EPA chemical code

PubChem CID

53491464

Molecular mass

398.23

PIN (Preferred Identification Name)

rac-N-[(1R,4S)-9-(dichloromethylidene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide

IUPAC name

N-((1RS,4SR)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl)-3-(difluoromethyl)-1-methylpyrazole-4-carboxamide

CAS name

N-(9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide

Other status information

Relevant Environmental Water Quality Standards

Herbicide Resistance Classification (HRAC)

Not applicable

Herbicide Resistance Classification (WSSA)

Not applicable

Insecticide Resistance Classification (IRAC)

Not applicable

Fungicide Resistance Classification (FRAC)

Examples of recorded resistance

Physical state

White powder

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

Aprovia
Trivapro
Elatus

Example products using this active

Syngenta

Formulation and application details

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

0.98

at 25 °C

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

350000

Acetone

450000

Dichloromethane

190000

Ethyl acetate

76000

Methanol

Melting point (°C)

148.4

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

285

Flashpoint (°C)

Not expected to self-ignite: Not highly flammable

Octanol-water partition coefficient at pH 7, 20 °C

2.00 X 10⁰⁴

Calculated

Log P

4.3

at 25 °C

High

Bulk density (g ml⁻¹)

Dissociation constant pKa) at 25 °C

N/a

No dissiciation

Vapour pressure at 20 °C (mPa)

3.2 X 10^-06

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

1.3 X 10^-06

Non-volatile

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Neutral: 220nm=30539, 249nmj=11864, 295nm=962
Acidic: 220nm=29989, 249nm=11712, 295nm=1008
Basic: 220nm=28442, 249nm=11527, 295nm=1111

Surface tension (mN m⁻¹)

63.0

90% sat soln

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

908

Very persistent

DT₅₀ (lab at 20 °C)

908

Very persistent

DT₅₀ (field)

127.3

Persistent

DT₉₀ (lab at 20 °C)

1000

Very persistent

DT₉₀ (field)

840.5

DT₅₀ modelling endpoint

184

Geometric mean field studies

Note

EU 2015 dossier lab studies DT₅₀ (normalised) range 596-1216 days; DT₉₀ (measured) >1000 days, Soils=6; Field studies DT₅₀ (measured) range 0.001-336 days, DT₉₀ (measured) range 542-840 days, Soils=6

Dissipation rate RL₅₀ on plant matrix

Value

Note

Dissipation rate RL₅₀ on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

44.2

Stable

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Stable

Note

Stable at all relevant pHs

Water-sediment DT₅₀ (days)

559

Stable

Water phase only DT₅₀ (days)

27.1

Slow

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d

K_oc

Notes and range

Freundlich

K_f

62.1

Slightly mobile

K_foc

3697

¹/_n

0.91

Notes and range

EU 2015 dossier K_f range 31.6-93.3 mL g⁻¹, K_foc range 3172-4507 mL g⁻¹, ¹/_n range 0.88-0.93, Soils=6

pH sensitivity

None

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

0.91

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

1.82 X 10^-02

Calculated

Note

Potential for particle bound transport index

High

Calculated

Potential for loss via drain flow

Slightly mobile

Calculated

Key metabolites

Metabolite

Formation medium

Estimated maximum occurrence fraction

1107/2009 relevancy

desmethyl-benzovindiflupyr (Ref: SYN546206)

Soil

0.056

Minor fraction; Relevant

pyrazole acid (Ref: CSAA798670)

Soil

0.118

Major fraction; Relevant

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

Metabolising enzymes

N-[(1R,4S)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxamide

SYN546527

Soil

N-[(1R,2R,4S)-9-(dichloromethylene)-2-hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxamide

SYN546039; CSCS695908

Plants; Animals

N-[(1R,2S,4S)-9-(dichloromethylene)-2-hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxamide

SYN546040

Soil; Surface water

N-[(1R,2R,4S)-9-(dichloromethylene)-2-hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1H-pyrazole-4-carboxamide

SYN546041

Animals; Surface water

N-[(1R,2S,4S)-9-(dichloromethylene)-2-hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1H-pyrazole-4-carboxamide

SYN546042

Animals

N-[(1R,3S)-2-(dichloromethylene)-3-hydroxy-1-(2-hydroxyethyl)-2,3-dihydro-1H-inden-4-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide

SYN546422

Animals

3-(difluoromethyl)-1-methylpyrazole-4-carboxamide

SYN508272

Soil; Surface water

3-(difluoromethyl)-1H-pyrazole-4-carboxylic acid

SYN545720

Plants; Animals

ECOTOXICOLOGY

Property

Value

Source; quality score; and other information

Interpretation

Bio-concentration factor

BCF (l kg⁻¹)

123

Threshold for concern

CT₅₀ (days)

0.54

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

A5 55.0

High

Mammals - Short term dietary NOEL

(mg kg⁻¹)

A5 17.5

High

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

6.8

Rat Reproductive NOAEL

High

Birds - Acute LD₅₀ (mg kg⁻¹)

1315

Colinus virginians

Moderate

Birds - Short term dietary (LC₅₀/LD₅₀)

> 5625 mg kg feed⁻¹

Colinus virginians

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

Anas platyrhynchos NOEC

Moderate

Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

0.0035

Cyprinus carpio

High

Fish - Chronic 21 day NOEC (mg l⁻¹)

0.00095

Pimephales promelas

High

Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

0.085

Dapnia magna

High

Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

0.015

Dapnia magna

Moderate

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

0.056

Americamysis bahia

High

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

6.7

Chironomus riparius

Moderate

Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)

> 0.88

Lemna gibba

Moderate

Non-target plants

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

> 0.89

Pseudokirchneriella subcapitata

Moderate

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100

Apis mellifera

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 109

Apis mellifera

Low

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other pollinators (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other pollinators (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

203.15

Eisenia foetida corr

Moderate

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

3.91

Eisenia foetida corr

Moderate

Other soil macro-organisms

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

47.7

Folsomia candida

Other arthropod (1)

LR₅₀ g ha⁻¹

6000

>
Typhlodromus pyri

% Effect

Other arthropod (2)

LR₅₀ g ha⁻¹

2825

=
Aphidius rhopalosiphi

% Effect

Soil micro-organisms

Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect

Dose: 1.37 mg kg⁻¹ soil 28 days

Mesocosm study data

NOEAEC mg l⁻¹

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

A5 55.0

High

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

0.56

Rat 4hr (nose only)

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.05

Rat SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

0.1

Rat SF=100

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.04

Rat SF=100

Dermal penetration studies (%)

1-3%

concentration dependent

Dangerous Substances Directive 76/464

Exposure Routes

Public

Negligible risk for bystanders and residents

Occupational

Low risk with PPE/PPC

European MRLs

EU MRL pesticide database

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

No data found

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

No data found

General human health issues

Possible liver toxicant

Handling issues

Property

Value and interpretation

General

Not oxidising or explosive

CLP classification 2013

Health: H301, H331
Environment: H400, H410

EC Risk Classification

EC Safety Classification

WHO Classification

NL (Not listed)

UN Number

Waste disposal & packaging

TRANSLATIONS

Language

Name

English

benzovindiflupyr

French

benzovindiflupyr

German

Danish

Italian

Spanish

Greek

Polish

Swedish

Hungarian

Dutch

Record last updated:	12/01/2021
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242