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ethofumesate (Ref: AE B049913)
** NC 8438 ** SN 49913 ** HBX06 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for ethofumesate

Description: A pre- and post-emergence herbicide for grasses and broad-leaved weed control in various crops

Example pests controlled: Black nightshade; Chickweed; Lambsquarters; Purslane; Pigweed; Thistles; Annual bluegrass; Foxtails; Volunteer cereals; White grass

Example applications: Sugarbeet; Red beet; Fodder beet; Onions, gallic & shallots; Carrots; Grass seed crops; Oilseed poppies

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1969, first reported; 1974, first introduced

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Austria/Denmark
Date inclusion expires 31/10/2031
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule, ethofumesate is an isomeric mixture
Chemical formula C13H18O5S
Canonical SMILES CCOC1C(C2=C(O1)C=CC(=C2)OS(=O)(=O)C)(C)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) IRCMYGHHKLLGHV-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C13H18O5S/c1-5-16-12-13(2,3)10-8-9(18-19(4,14)15)6-7-11(10)17-12/h6-8,12H,5H2,1-4H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Benzofuran
Minimum active substance purity 960 g/kg active, max 5 g/kg water
Known relevant impurities EU dossier (RAR) - methanesulfonic acid ethyl ester < 0.1 mg/kg; 1,1-dimethyl-2-((methylsulfonyl)oxy)-ethyl < 0.1 mg/kg
Substance origin Synthetic
Mode of action Selective, systemic, absorbed through emerging shoots and roots. Inhibition of lipid synthesis.
CAS RN 26225-79-6
EC number 247-525-3
CIPAC number 233
US EPA chemical code 110601
PubChem CID 33360
Molecular mass (g mol-1) 286.34
PIN (Preferred Identification Name) rac-(2R)-2-ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl methanesulfonate
IUPAC name (RS)-2-ethoxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulfonate
CAS name 2-ethoxy-2,3-dihydro-3,3-dimethyl-5-benzofuranyl methanesulfonate
Other status information Potential groundwater contaminant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) N
Herbicide Resistance Classification (WSSA) 8
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White to beige coloured crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • BASF
  • Makhteshim-Agan
  • Nufarm UK
  • Bayer CropScience
Example products using this active
  • Betanal Expert
  • Ethosat 500
  • Galahad
  • Goltix Super
  • Magnum
  • Nortron Flow
  • Twin
  • Ethofumesate SC 500
  • Ethofol 500 SC
UK LERAP status None
Formulation and application details Often supplied as a soluble concentrate which is mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for ethofumesate

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 50 A5 - @ 25 DegC Moderate
Solubility - In organic solvents at 20oC (mg l-1) 260000 A5 - Acetone -
600000 A5 - Dichloromethane -
600000 A5 - Ethyl acetate -
114000 A5 - Methanol -
Melting point (oC) 70.7 A5 -
Boiling point (oC) Decomposes before / on boiling @ 305-320 Deg C A5 -
Degradation point (oC) >220 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 5.01 X 1002 Calculated -
Log P 2.7 A5 Moderate
Bulk density (g ml-1)/Specific gravity 1.3 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.36 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.72 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.57 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.35 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral pH: 203nm=19441; 228nm=7228; 281nm=2797; 291nm=1412
Acidic pH: 202nm=24122; 227nm=7339; 280nm=2797; 291nm=1357
Basic pH: 202.5nm=17362; 227nm=6716; 280.5nm=2546
A5 -
Surface tension (mN m-1) 68.3 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 21.6 A5 Non-persistent
DT50 (lab at 20oC) 21.6 A5 Non-persistent
DT50 (field) 37.8 A5 Moderately persistent
DT90 (lab at 20oC) 100.6 A5 -
DT90 (field) 264 A5 -
DT50 modelling endpoint - - -
Note EU dossier (2016) lab studies DT50 range 8.5-80.5 days, DT50 range 38.7-228 days, Soils =18; Field studies DT50 range 13.5-110 days, DT90 range 72-522 days, Soils = 13; Other data DT50 30 days (DW4)
Dissipation rate RL50 on plant matrix Value 6.2 R3 -
Note Ryebrass blades, n=1
Dissipation rate RL50 on and in plant matrix Value 3.0 R3 -
Note Creeping bent blades, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 15.6 A5 Slow
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 9.2
Water-sediment DT50 (days) 591 A5 Stable
Water phase only DT50 (days) 20 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 1.74 A5 Moderately mobile
Kfoc 118
1/n 0.91
Notes and range EU dossier (2016) Kf range 0.7-6.2 mL/g, Kfoc range 48-247 mL/g, 1/n range 0.84-0.96, Soils=12
pH sensitivity No


ECOTOXICOLOGY

for ethofumesate

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 144 A5 Threshold for concern
CT50 (days) 1 -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - A4 Rabbit -
(ppm diet) 300 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 5200 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 10.92 A5 Cyprinus carpio Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.8 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 13.52 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.32 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 4.5 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 5.0 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 52.8 A5 Lemna minor Low
Non-target plants > 2.0 A5 Avena sativa
Vegetative vigour, ER50
as L product SC 500 /ha
-
0.328 A5 Avena sativa
Seedling emergence, ER50
as L product SC 500/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 3.9 A5 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 6.7 A5 Scenedesmus subspicatus Low
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 50 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 50 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 134 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) > 25 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 1000 >
A5 Typhlodromus pyri
-
% Effect 0
0
Mortality
Egg production
Dose: 1.25 kg ha-1
A5 Aleochara bilineata, adult
-
Other arthropod (2) LR50 g ha-1 1000 >
A5 Aphidius rhopalosiphi
-
% Effect 0
0
Mortality
Egg production
Dose: 2.0 kg ha-1
A5 Chrysoperla carnea, larvae
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: up to 13.8 mg kg-1 soil, 42 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for ethofumesate

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class Low (class I) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 0.16 A5 Rat, 4 hr (whole body) -
Other Mammal toxicity endpoints LD50 > 2000 A5 Rat -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.07 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 2.5 A4 Dog, 90 day, SF=100 -
Dermal penetration studies (%) 0.4-8 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Minimal risk of dietary exposure
Minimal risk to bystanders and residents
Occupational Minimal risk for operators and farm workers
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Harmful in contact with skin and if swallowed
Possible liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of mists
IMDG Transport Code is usually 9
Not explosive or oxidising
CLP classification 2013 Health: H302
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R51, R53
EC Safety Classification Click here to view information omn the EU safety phrases S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number Usually 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for ethofumesate

Language Name
English ethofumesate
French ethofumesate
German Ethofumesat
Danish ethofumesat
Italian etofumesate
Spanish etofumesato
Greek ethofumesate
Slovenian etofumesat
Polish etofumesat
Swedish etofumesat
Hungarian etofumezat
Dutch ethofumesaat

Record last updated: Wednesday 23 May 2018
Contact: aeru@herts.ac.uk