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amidosulfuron
** HOE 075032 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Amidosulfuron is a broad spectrum herbicide that has approval for use in the EU. It is volatile, highly soluble in water and, based on its chemical properties, has a high potential for leaching to groundwater. It is not persistent in soil systems but may be persistent in water under certain conditions. It has a low mammalian toxicity and would not be expected to bioaccumulate. Amidosulfuron is moderately toxic to most terrestrial and aquatic species.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for amidosulfuron

Description: A post-emergence sulfonylurea herbicide for cleavers and other broad-leaved weed control particularly in cereals

Example pests controlled: Docks; Charlock; Hempweed; Chickweed; Buttercups; Nettles; Mayweed; Shepherd's purse; Forgetmenot; Field pansy

Example applications: Cereals including wheat, barley, oats, triticale; Linseed; Grassland; Clover

Efficacy & activity: -

Availability status: Current

Introduction & key dates: circa 1992

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Finland/Hungary
Date inclusion expires 31/12/2018
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C9H15N5O7S2
Canonical SMILES CN(S(=O)(=O)C)S(=O)(=O)NC(=O)NC1=NC(=CC(=N1)OC)OC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) CTTHWASMBLQOFR-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H15N5O7S2/c1-14(22(4,16)17)23(18,19)13-9(15)12-8-10-6(20-2)5-7(11-8)21-3/h5H,1-4H3,(H2,10,11,12,13,15)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Sulfonylurea
Minimum active substance purity 970 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Selective, systemic absorbed through leaves and roots. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS
CAS RN 120923-37-7
EC number 407-380-0
CIPAC number 515
US EPA chemical code -
PubChem CID 91777
Molecular mass (g mol-1) 369.41
PIN (Preferred Identification Name) N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide
IUPAC name 1-(4,6-dimethoxypyrimidin-2-yl)-3-mesyl(methyl)sulfamoylurea
CAS name N-(4,6-dimethoxy-2-pyrimidinyl)-3-methyl-2,4-dithia-3,5-diazahexan-6-amide-2,2,4,4-tetraoxide
Other status information PAN Listed as Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) B
Herbicide Resistance Classification (WSSA) 2
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Stellaria media
Physical state White crystalline powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
  • Landgold
  • Kingtai Chemicals
Example products using this active
  • Artemis
  • Chekkar
  • Druid
  • Eagle
  • Squire
  • Sekator
  • Squire
  • Gratil
UK LERAP status None
Formulation and application details Spray application using water dispersible granules.


ENVIRONMENTAL FATE

for amidosulfuron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 3070 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 256 A5 - Acetone -
3000 A5 - Ethyl acetate -
256 A5 - Toluene -
1 A5 - n-Hexane -
Melting point (oC) 179 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.75 X 10-02 Calculated -
Log P -1.56 A4 Low
Bulk density (g ml-1)/Specific gravity 1.51 A5 -
Dissociation constant (pKa) at 25oC 3.58 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 0.013 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 5.22 X 10-04 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 3.06 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.97 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 201nm = 31649, 241nm = 14938, 291nm = 10; [Acidic solution: 201nm = 33226, 241nm = 13978, 291nm = 20; [Basic solution = 241nm = 22442, 291nm = 12 A5 -
Surface tension (mN m-1) 66.2 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 21 B4 Non-persistent
DT50 (lab at 20oC) 16.6 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 55 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 3-29 days, DT50 range 10 - 97 days; Other lab studies DT50 range 3-27 days (USA)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 7-9, DT50 >365 days; DT50 34 days at pH 5
Water-sediment DT50 (days) 91 A5 Moderately fast
Water phase only DT50 (days) 73 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 0.34 A5 Mobile
Koc 29.3
Notes and range EU dossier Kd range 0.06-0.61 mL/g, Koc range 3.4-84.7 mL/g, Soils=3
Freundlich Kf 0.56 A5 Mobile
Kfoc 31.1
1/n 1.09
Notes and range EU dossier Kf range 0.03-2.37 mL/g, Kfoc range 2.6-81.9 mL/g, 1/n range 0.91-1.74, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
3-(4-hydroxy-6-methoxypyrimidin-2-yl)-1-(N-methyl-N-methylsulfonyl-aminosulfonyl)-urea (Ref: AE-F101630) This metabolite may cause environmental pollution, click here for further information Soil   0.496   Major fraction, Relevant
3-(5,6-hydroxy-4-methoxypyrimidin-2-yl)-1-(N-methyl-N-methylsulfonyl-aminosulfonyl)-urea (Ref: AE-F128870) This metabolite may cause environmental pollution, click here for further information Soil   0.386   Major fraction, Not relevant
3-(5-hydroxy-4,6-dimethoxypyrimidin-2-yl)-1-(N-methyl-N-methylsulfonyl-aminosulfonyl)-urea (Ref: AE 1569309) This metabolite may cause environmental pollution, click here for further information Soil   0.121   Major fraction, Not relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2-amino-4,6-dihydroxypyrimidine
(Ref: AEF094206)
- Soil 0.109 -


ECOTOXICOLOGY

for amidosulfuron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 4.85 Q2 Estimated Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) >= 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 411 B5 Rat Moderate
(ppm diet) > 5000 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 320 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 6.41 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 36 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 1.0 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.0092 A5 Lemna gibba High
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 47 A4 Scenedemus subspicatus Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 33.3 Mortality
Dose: 0.045 kg ha-1
A5 Aphidius rhopalosiphi, adults
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 2.4 Mortality
Dose: 0.045 kg ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.2 mg kg-1, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for amidosulfuron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) >= 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 1.8 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.2 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 1.4 A5 Dog, SF=100 -
Dermal penetration studies (%) 100 A3 default -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Acceptable for proposed uses
Occupational Acceptable for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Harmful if swallowed

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is product is usually 9
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for amidosulfuron

Language Name
English amidosulfuron
French amidosulfuron
German Amidosulfuron
Danish amidosulfuron
Italian amidosulfuron
Spanish amidosulfuron
Greek -
Slovenian amidosulfuron
Polish amidosulfuron
Swedish amidosulfuron
Hungarian amidsulphuron
Dutch amidosulfuron

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk