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flonicamid (Ref: IKI 220)
** F 1785 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for flonicamid

Description: An insecticide used to control aphids, thrips and whitefly in a range of situations including glasshouses

Example pests controlled: Aphids, Thrips, Whiteflies

Example applications: Fruit including apples, peaches; Wheat; Potatoes; Various vegetables

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 2000

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur France/Sweden
Date inclusion expires 31/08/2023
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C9H6F3N3O
Canonical SMILES C1=CN=CC(=C1C(F)(F)F)C(=O)NCC#N
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) RLQJEEJISHYWON-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H6F3N3O/c10-9(11,12)7-1-3-14-5-6(7)8(16)15-4-2-13/h1,3,5H,4H2,(H,15,16)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Aphicide
Substance group Pyridine compound
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier - Toluene max. 3g/kg
Substance origin Synthetic
Mode of action Systemic, selective with long term activity. Thought to distrub insect feeding pattern.
CAS RN 158062-67-0
EC number -
CIPAC number 763
US EPA chemical code 128016
PubChem CID 9834513
Molecular mass (g mol-1) 229.16
PIN (Preferred Identification Name) N-(cyanomethyl)-4-(trifluoromethyl)pyridine-3-carboxamide
IUPAC name N-cyanomethyl-4-(trifluoromethyl)nicotinamide
CAS name N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 9C
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance None recorded
Physical state Off-white powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Belchim
  • ISK Biosciences
  • FMC Corp
Example products using this active
  • Teppeki
  • Beleaf
  • Carbine
  • Mainman
UK LERAP status None
Formulation and application details Often supplied as wettable granules that are mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for flonicamid

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 5200 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 163500 A5 - Acetone -
34200 A5 - Ethyl acetate -
4500 A5 - Dichloromethane -
550 A5 - Toluene -
Melting point (oC) 157.5 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 313 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 5.75 X 10-01 Calculated -
Log P -0.24 A5 Low
Bulk density (g ml-1)/Specific gravity 1.54 A5 -
Dissociation constant (pKa) at 25oC 11.6 A5 -
Note: Strong base
Vapour pressure at 20oC (mPa) 9.43 X 10-04 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 4.20 X 10-08 L3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.16 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.19 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 265nm = 3870; [Acidic solution: 266nm = 3890; [Basic solution: 204nm = 13200, 270nm = 4190 A5 -
Surface tension (mN m-1) 47.3 A5 at 25oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 3.1 F3 Non-persistent
DT50 (lab at 20oC) 1.1 A5 Non-persistent
DT50 (field) 3.1 F3 Non-persistent
DT90 (lab at 20oC) 3.5 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies range DT50 0.7-1.8 days, DT90 range 2.3-6.0 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 4.0 R4 -
Note Published literature RL50 range 3.0-5.6 days, 4 field crops, various matrices, n=4
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable at pH 4 and 7, 204 days at pH 9
Water-sediment DT50 (days) 40 A5 Moderately fast
Water phase only DT50 (days) 33.8 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 0.09 A5 Very mobile
Koc 1.6
Notes and range EU dossier Kd range 0.03-1.7 mL/g, Koc range 0.7-3.0 mL/g, Soils=4
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
4-trifluoromethylnicotinic acid This metabolite may cause environmental pollution, click here for further information Soil   0.364   Major fraction, Relevant
N-(4-trifluoromethyl-nicotinoyl)glycinamide This metabolite may cause environmental pollution, click here for further information Soil   0.102   Major fraction, Relevant
6-hydroxy-4-trifluoromethylnicotinic acid This metabolite may cause environmental pollution, click here for further information Soil   0.213   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
- TFNG Rat (Urinary); Plant; Animal - -
- TFNG-AM Rat (Urinary); Plant; Soil - -
- IKI-220 N-oxide Rat (Urinary) - -
- TFNA-AM oxide Rat (Urinary) - -
- OH-TFNA-AM Rat (Urinary) - -


ECOTOXICOLOGY

for flonicamid

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 884 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 25 F2 Rabbit High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 411 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 100 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 10 A5 Pimephales promelas Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 100 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 3.1 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 119 A5 Lemna gibba, Biomass Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 100 A5 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 51100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 53300 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 22.2 Mortality
Dose: 80g ha-1
A5 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 80g ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: not known
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for flonicamid

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 884 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 4.9 A5 Rat, 4 hr (nose only, aerosol) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.025 A5 Rabbit, SF=100 [Other data: 0.01, UK ACP 2005] -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.025 A3 Rabbit, SF=100 [Other data: 0.04, UK ACP 2005] -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.025 A3 Rabbit, SF=100 [Other data: 0.04, UK ACP 2005] -
Dermal penetration studies (%) 7.46-13.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No risks anticipated
Occupational PPE/PPC advised in order to mitigate risks
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; Calc MAC=219.0 μg l-1; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible liver and kidney toxicant
USEPA - some evidence to suggest possible human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H319
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
N - Dangerous for the environment: R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S46
WHO Classification NL - Not listed
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for flonicamid

Language Name
English flonicamid
French flonicamide
German Flonicamid
Danish flonicamid
Italian flonicamid
Spanish flonicamida
Greek -
Slovenian flonikamid
Polish flonikamid
Swedish flonicamid
Hungarian -
Dutch -

Record last updated: Thursday 13 September 2018
Contact: aeru@herts.ac.uk