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fluometuron
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for fluometuron

Description: A soil applied selective herbicide used to control annual grasses and broad-leaved weeds

Example pests controlled: Annual grasses, Broad-leaved weeds

Example applications: Cotton; Sugarcane

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1964, first reported; 1970s, first marketed

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Spain/Belgium
Date inclusion expires 31/05/2021
EU Candidate for substitution (CfS) Yes - low ADI / ARfD / AOEL
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C10H11F3N2O
Canonical SMILES CN(C)C(=O)NC1=CC=CC(=C1)C(F)(F)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) RZILCCPWPBTYDO-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H11F3N2O/c1-15(2)9(16)14-8-5-3-4-7(6-8)10(11,12)13/h3-6H,1-2H3,(H,14,16)
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
Fluometuron - Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Phenylurea
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Photosynthetic electron transport inhibitor at the photosystem II. Bleaching: 4-HPPD.
CAS RN 2164-17-2
EC number 218-500-4
CIPAC number 159
US EPA chemical code 035503
PubChem CID 16562
Molecular mass (g mol-1) 232.20
PIN (Preferred Identification Name) -
IUPAC name 1,1-dimethyl-3-(α,α,α-trifluoro-m-tolyl)urea
CAS name N,N-dimethyl-N'-(3-(trifluoromethyl)phenyl)urea
Other status information Potential groundwater contaminant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) C2 & F3
Herbicide Resistance Classification (WSSA) 7 & 11
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
  • Makhteshim
  • Nufarm
Example products using this active
  • Fluometron 50 SC
  • Cottonex 50 SC
  • Cotoran 50 SC
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as a suspension concentrate that is mixed with water and used as a spray.


ENVIRONMENTAL FATE
for fluometuron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 111 A5 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 109000 A5 - Methanol -
144000 A5 - Acetone -
1980 A5 - Xylene -
20600 A5 - n-Octanol -
Melting point (oC) 152.5 A5 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.91 X 1002 Calculated -
Log P 2.28 A5 - @ 23.5 DegC Low
Bulk density (g ml-1)/Specific gravity 1.39 L3 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.125 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.63 X 10-04 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 3.92 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.04 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 243nm = 17300, 279nm = 1230; [Acidic solution: 243nm = 17700, 279nm = 1390; [Basic solution: 243nm = 17400, 279nm = 1360 A5 -
Surface tension (mN m-1) 61.5 A5 at 25oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 63.6 A5 Moderately persistent
DT50 (lab at 20oC) 63.6 A5 Moderately persistent
DT50 (field) 89.8 A5 Moderately persistent
DT90 (lab at 20oC) 202.0 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 22.5-235.1 days, DT90 range 74.8-384.1 days, field studies DT50 range 62.5-117 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 6.0 R3 -
Note Ryegrass leaves, n=1
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Stable pH 5 and pH 7 at 25 degC
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 9 at 25 degC
Water-sediment DT50 (days) 524 A3 Stable
Water phase only DT50 (days) 88 A3 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 0.87 A5 Mobile
Kfoc 67.4
1/n 0.963
Notes and range EU dossier Kf range 0.079-2.809, kfoc range 30.8-117 mL/g, 1/n range 0.886-1.129, Soils=8
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
desmethyl fluometuron (Ref: CGA 41686) This metabolite may cause environmental pollution, click here for further information Soil   0.547   Major fraction, Relevant
m-trifluoromethylaniline (Ref: CGA 72903) This metabolite may cause environmental pollution, click here for further information Soil   0.159   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
trifluroactetic acid
Note: Toxicologically relevant; Oral LD50 200 mg kg-1 		TFAA Plant (cotton) - -
hydroxylated n-acetyl - Rat - -
trifluromethylanaline TFMA Plant - -
hydroxylated fluometuron
(Ref: CGA 13211) 		- Rat; Plant (cotton) - -
hydroxylated di-desmethyl fluometuron
(Ref: CGA 236431) 		- Rat; Plant (cotton) - -
hydroxylated desmethyl fluometuron
(Ref: CGA 236432) 		- Rat; Plant (cotton) - -
(Ref: CGA 41690) - Plant - -
di-desmethyl fluometuron
(Ref: CGA 41698) 		- Rat; Plant - -


ECOTOXICOLOGY
for fluometuron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 40.4 A5 Whole fish Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 19 L2 Rat, 2 year High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 2974 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 1597 mg kg bw-1 day-1 A4 Colinus virginianus, chicks -
Fish - Acute 96 hour LC50 (mg l-1) 30 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 4.3 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 54 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 18 A5 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 6.8 A5 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.2 F3 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.32 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.0661 A5 Pseudokirchneriella subcapitata Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 34.0 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 15 A5 Eisenia foetida, corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect 113 A5 Folsomia candida, 28 day EC50 survival mg kg-1 -
Other arthropod (1) LR50 g ha-1 28.9 Reproductive effect
A5 Typhlodromus pyri 		-
% Effect 12.9 Mortality
Dose: 2.0 kg ha-1
A5 		-
Other arthropod (2) LR50 g ha-1 398 Fecundity
A5 Aphidius rhopalosiphi 		-
% Effect 5.0 Mortality
Dose: 2.0 kg ha-1
A5 		-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect 		A5
Dose: 5x 2 kg ha-1, 28days 		-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION
for fluometuron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 4.62 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0005 A4 Rat, SF=1000 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.008 A4 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.008 A4 Rat, SF=100 -
Dermal penetration studies (%) 0.6-6.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; Calc MAC=6.6 μg l-1; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Exposure may lead to convulsions or coma
May cause reduced blood pressure
May cause haemolytic anaemia
IARC Group 3 carcinogen; USEPA - possible human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 None allocated at this time
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Reproduction risk category 3: R63
Xn - Harmful: R64
N - Dangerous for the environment: R51, R53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS
for fluometuron

Language Name
English fluometuron
French fluometuron
German Fluometuron
Danish fluometuron
Italian fluometuron
Spanish fluometuron
Greek -
Slovenian fluometuron
Polish fluometuron
Swedish -
Hungarian -
Dutch -

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk