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flusilazole (Ref: DPX H6573)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for flusilazole

Description: A curative and preventative fungicide used to control a range of fungal pathogens including Ascomycetes, Basidiomycetes and Deuteromycetes spp..

Example pests controlled: Apple scab, Powdery mildew, Sigatoka disease, Eyespot, Rusts, Black rot

Example applications: Fruit including apples, pears, apricots, plums, peaches, bananas, grapes; Sugarbeet; Oilseed rape; Cereals

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1984, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Ireland
Date inclusion expires -
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None
Chemical formula C16H15F2N3Si
Canonical SMILES C[Si](CN1C=NC=N1)(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) FQKUGOMFVDPBIZ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Triazole
Minimum active substance purity 925 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Broad-spectrum, systemic with protective and curative action. Sterol biosynthesis inhibitor.
CAS RN 85509-19-9
EC number -
CIPAC number 435
US EPA chemical code 128835
PubChem CID 73675
Molecular mass (g mol-1) 315.39
PIN (Preferred Identification Name) -
IUPAC name bis(4-fluorophenyl)(methyl)(1H-1,2,4-triazol-1-ylmethyl)silane
CAS name 1-((bis(4-fluorophenyl)methylsilyl)methyl)-1H-1,2,4-triazole
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 3
Examples of recorded resistance -
Physical state White to brown coloured crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • DuPont
Example products using this active
  • Capitan 25
  • Charisma
  • Colstar
  • Genie 25
  • Harvesan
  • Lyric
  • Nustar
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Often supplied as an oil emulsion that is mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for flusilazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 41.9 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 85000 B4 - Hexane -
85000 A5 - n-Hexane -
200000 A4 - Ethyl acetate -
200000 A4 - Xylene -
Melting point (oC) 53.2 A5 -
Boiling point (oC) 393 L3 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 7.41 X 1003 Calculated -
Log P 3.87 A5 High
Bulk density (g ml-1)/Specific gravity 1.31 A5 -
Dissociation constant (pKa) at 25oC 2.5 A5 -
Note: Very weak base
Vapour pressure at 20oC (mPa) 0.0387 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.70 X 10-04 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.05 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 9.01 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: Maxima at 206nm; [Acidic & basic solutions: Maxima at 202nm A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 300 B5 Persistent
DT50 (lab at 20oC) 427 A5 Very persistent
DT50 (field) 94 B4 Moderately persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier gives lab studies DT50 value circa 14 months, field studies DT50 range 63-240 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 5.3 R4 -
Note Published literature RL50 range 1.3-7.4 days, 4 field crops, various matrices, n=4
Aqueous photolysis DT50 (days) at pH 7 Value 70 K4 Stable
Note Insignificant route of degradation
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A4 -
Note Stable pH 5 to pH 9 for up to 34 days at 25 degC
Water-sediment DT50 (days) 365 K4 Stable
Water phase only DT50 (days) 1 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - A5 Slightly mobile
Koc 1664
Notes and range EU dossier Koc range 984-2031 mL/g
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
bis(4-fluorophenyl)methyl silanol (Ref: IN-F7321) Soil   0.05   Minor fraction, Not relevant


ECOTOXICOLOGY

for flusilazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 250 P4 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 674 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) > 6.25 B5 Rat High
(ppm diet) > 125 -
Birds - Acute LD50 (mg kg-1) > 1590 A5 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) 1584 ppm A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 1.2 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.023 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 3.4 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.27 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) >= 0.001 A5 Chironomus riparius High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 6.4 A5 Selenestrum capricornutum Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 1 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) 165 A5 Low
Oral acute 48 hour LD50 (μg bee-1) 33.8 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 388 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 8.82 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 38 g ha-1
A5 Typhlodromus pyri
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 600 g ha-1
A5 Aphidius rhopalosiphi
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2 kg ha-1, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for flusilazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 674 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 2.7 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.002 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Acceptable risk for bystanders
Occupational Acceptable risk for operators and other workers
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Endocrine issues - Inhibition of aromatase activity, decrease of estrogens production

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
IMDG Transport Code is usually 9
CLP classification 2013 Health: H302, H351, H360D
Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Reproduction risk category 2: R61
Xn - Harmful: R22
N - Dangerous for the environment: R51, R53
EC Safety Classification Click here to view information omn the EU safety phrases S45, S53, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 2588 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for flusilazole

Language Name
English flusilazole
French flusilazole
German Flusilazol
Danish flusilazol
Italian flusilazole
Spanish flusilazol
Greek flusilazole
Slovenian flusilazol
Polish flusilazol
Swedish -
Hungarian fluzilazol
Dutch flusilazole

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk