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glufosinate-ammonium (Ref: HOE 039866)
** phosphinothricin ammonium ** AE F039866 ** HOE 00661 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Glufosinate-ammonium is a herbicide approved for use in the EU. It is highly soluble in water, volatile and has a low risk of leaching to groundwater. It is non-persistent in soils but may be persistent in aquatic systems. It is moderately toxic to mammals and considered to be a neurotoxin. It shows a moderate to low toxicity to birds, most aquatic organisms, earthworms and honeybees.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for glufosinate-ammonium

Description: A herbicide for total vegetation control and to control a wide range of weeds and grasses

Example pests controlled: Annual broad-leaved weeds including nightshade, lamb's quarters, ragweed, velvetleaf, wild mustard; Annual grasses including barnyard grass, bristly foxtail, witchgrass

Example applications: Oilseed rape; Maize; Potatoes; Soybeans; Non-cropped areas

Efficacy & activity: -

Availability status: Current

Introduction & key dates: circa 1982

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Germany/France
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Yes - toxic for reproduction
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A molecule with 2 chiral centres, glufosinate-ammonium is an isomeric mixture of the D- and L-isomers of the glufosinate ammonium salt
Chemical formula C5H15N2O4P
Canonical SMILES CP(=O)(CCC(C(=O)[O-])N)O.[NH4+]
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) ZBMRKNMTMPPMMK-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C5H12NO4P.H3N/c1-11(9,10)3-2-4(6)5(7)8;/h4H,2-3,6H2,1H3,(H,7,8)(H,9,10);1H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Phosphinic acid
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Non-selective, contact with some systemic action. Glutamine synthetase inhibitor: accumulates ammonium ions, inhibits photosynthesis.
CAS RN 77182-82-2
EC number 278-636-5
CIPAC number 437
US EPA chemical code 128850
PubChem CID 53597
Molecular mass (g mol-1) 198.2
PIN (Preferred Identification Name) -
IUPAC name ammonium (2RS)-2-amino-4-(methylphosphinato)butyric acid
CAS name 2-amino-4-(hydroxymethylphosphinyl)butanoic acid monoammonium salt
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) H
Herbicide Resistance Classification (WSSA) 10
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Aventis
  • Bayer CropScience
  • Certis
  • Fargro
  • Hoechst
Example products using this active
  • Basta
  • Harvest
  • Kaspar
UK LERAP status None
Formulation and application details Often supplied as a soluble or emulsifiable concentrate.


ENVIRONMENTAL FATE

for glufosinate-ammonium

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 500000 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 250 A5 - Acetone -
250 A5 - Ethyl acetate -
5730000 A5 - Methanol -
250 A5 - p-Xylene -
Melting point (oC) 216.5 A5 -
Boiling point (oC) Decomposes before boiling A3 -
Degradation point (oC) 245 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 9.77 X 10-05 Calculated -
Log P -4.01 A5 Low
Bulk density (g ml-1)/Specific gravity 1.32 A5 -
Dissociation constant (pKa) at 25oC 9.15 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 3.10 X 10-02 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 4.48 X 10-09 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.06 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 9.82 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 193nm = 382.02, 291nm = 3.12; [Acidic solution: 207.25nm = 57.05, 291nm = 0.31; [Basic solution: 216.75nm = 108.67, 291nm = no absorption A5 -
Surface tension (mN m-1) 72.1 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 7.4 A5 Non-persistent
DT50 (lab at 20oC) 7.4 A5 Non-persistent
DT50 (field) 7 B5 Non-persistent
DT90 (lab at 20oC) 25 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 6-11 days, DT90 range 19-35 days; Other sources: DT50 16 days (DW4); 3-10 days (Q3 lab), 7-20 (Q3 field)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Stable pH 5 to pH 9
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 300 A5 Persistent
Note Stable pH 5 to pH 9 at 25 degC
Water-sediment DT50 (days) 24.5 A5 Fast
Water phase only DT50 (days) 7.2 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - P3 Slightly mobile
Koc 600
Notes and range General literature: 10-1500 mL/g; US sources: 600 mL/g (DW3)
Freundlich Kf 2.3 A5 -
Kfoc -
1/n 0.93
Notes and range EU dossier kf range 0.2-3.4, 1/n range 0.77-1.0
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
3-methyl-phosphinico-propionic acid (Ref: AE-F061517) This metabolite may cause environmental pollution, click here for further information Soil   0.470   Major fraction, Relevant
2-methylphosphinico-acetic acid (Ref: AE-F064619) This metabolite may cause environmental pollution, click here for further information Soil   0.260   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
disodium L-2-acetamido-4-methylphosphinato-butyrate N-acetyl-glufosinate; NAG Rat (Urinary, Faeces); Plant; Water (Aerobic) - -
2-hydroxy-4-methylphosphinico-butanoic acid MHB Rat (Urinary) - -
4-methylphosphinico-butanoic acid MPB Rat (Urinary) - -


ECOTOXICOLOGY

for glufosinate-ammonium

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 416 A5 Mouse Moderate
Mammals - Short term dietary NOEL (mg kg-1) > 64 B5 Rat High
(ppm diet) > 545 -
Birds - Acute LD50 (mg kg-1) > 2000 B5 Coturnix japonica Low
Birds - Short term dietary (LC50/LD50) 1100 mg kg bw-1 day-1 A5 Coturnix japonica -
Fish - Acute 96 hour LC50 (mg l-1) 710 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 100 A5 Oncorhynchus mykiss Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 668 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 18 A5 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 7.5 A5 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 1.47 F4 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 46.5 F4 Scenedesmus quadricauda Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) 320 Q2 Unknown species Low
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 345 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 600 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 B5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.6 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.6 kg ha-1
A5 Typhlodromus pyri, adult
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: Field rate
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for glufosinate-ammonium

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 416 A5 Mouse Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 1.26 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.021 A5 Rat, SF=300 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.021 A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.0021 A5 Rat, SF=300 -
Dermal penetration studies (%) 7.0-16.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Slight risk to bystanders in orchards
Occupational Risk of exposure acceptable under label recommendations for use for personal protection clothing and equipment
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Harmful if ingested, inhaled or absorbed through the skin
Possible kidney, bladder, blood and lungs toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H302, H312, H332, H360DF, H373
EC Risk Classification Click here to view information omn the EU risk phrases Reproduction risk category 2 and 3: R60, R63
Xn - Harmful: R20/21/22, R48/20/22
EC Safety Classification Click here to view information omn the EU safety phrases S45, S53
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number Active is 2811, products vary with formulation usually 2902 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for glufosinate-ammonium

Language Name
English glufosinate-ammonium
French glufosinate-ammonium
German Glufosinat ammonium
Danish glufosinat-ammonium
Italian glufosinate-ammonio
Spanish glufosinato-amonico
Greek -
Slovenian glufosinat-amonij
Polish glufosynat amonowy
Swedish glufosinatammonium
Hungarian glufozinat-ammonium
Dutch glufosinaat-ammonium

Record last updated: Monday 05 November 2018
Contact: aeru@herts.ac.uk