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iodosulfuron-methyl-sodium (Ref: AE F115008)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Iodosulfuron-methyl-sodium is a sulfonylurea herbicide approved for use in the EU. It is highly soluble in aqueous solution and semi-volatile. It is not persistent in soil but may be in aquatic systems. It is highly toxic to mammals, a neurotoxin and a skin, eye and respiratory tract irritant. It is moderately toxic to birds, most aquatic organisms, honeybees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for iodosulfuron-methyl-sodium

Description: A post-emergence herbicide used to control weeds in cereals and other crops

Example pests controlled: Grass; Broad-leaved weeds

Example applications: Cereals including wheat, barley, corn; Turf; Soybean

Efficacy & activity: Scientifically proven to be selective in cereals, acting against a broad spectrum of grass weeds and a range of dicot weeds.

Availability status: Current

Introduction & key dates: circa 2000

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Sweden/Finland
Date inclusion expires 31/03/2032
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C14H13IN5NaO6S
Canonical SMILES CC1=NC(=NC(=N1)OC)NC(=O)[N-]S(=O)(=O)C2=C(C=CC(=C2)I)C(=O)OC.[Na+]
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) JUJFQMPKBJPSFZ-UHFFFAOYSA-M
International Chemical Identifier (InChI) InChI=1S/C14H14IN5O6S.Na/c1-7-16-12(19-14(17-7)26-3)18-13(22)20-27(23,24)10-6-8(15)4-5-9(10)11(21)25-2;/h4-6H,1-3H3,(H2,16,17,18,19,20,22);/q;+1/p-1/fC14H13IN5O6S.Na/h20H;/q-1;m
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Sulfonylurea
Minimum active substance purity 910 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Selective to cereals. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS
CAS RN 144550-36-7
EC number -
CIPAC number 634
US EPA chemical code 122021
PubChem CID 16760189
Molecular mass (g mol-1) 529.24
PIN (Preferred Identification Name) -
IUPAC name sodium ({[5-iodo-2-(methoxycarbonyl)phenyl]sulfonyl}carbamoyl)(4-methoxy-6-methyl-1,3,5-triazin-2-yl)azanide
CAS name sodium salt of methyl 4-iodo-2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)benzoate
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) B
Herbicide Resistance Classification (WSSA) 2
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Many recorded cases
Avena fatua
Phalaris mino
Alopecurus myosuroides
Papaver rhoeas
Sinapis alba
Physical state Beige coloured crystalline powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
Example products using this active
  • Atlantis WG
  • Chekkar
  • Hussar
  • Othello
  • Pacifica
  • Sekator
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as wettable granules that are mixed with water and used as a spray.


ENVIRONMENTAL FATE

for iodosulfuron-methyl-sodium

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 25000 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 11 A5 - n-Heptane -
12 A5 - n-Hexane -
2100 A5 - Toluene -
12000 A5 - Methanol -
Melting point (oC) 152 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 155 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.00 X 10-01 Calculated -
Log P -0.70 A5 Low
Bulk density (g ml-1)/Specific gravity 1.76 A5 -
Dissociation constant (pKa) at 25oC 3.22 A5 -
Note: Strong acid
Vapour pressure at 20oC (mPa) 2.6 X 10-06 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.29 X 10-11 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.01 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.24 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 In methanol: 291nm = 1471; [Methanol:NaOH (9:1): 291nm = 2073 A5 -
Surface tension (mN m-1) 72.0 A5 at 20 degC, 910 g/Kg -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 2.7 A5 Non-persistent
DT50 (lab at 20oC) 2.7 A5 Non-persistent
DT50 (field) 3.2 A5 Non-persistent
DT90 (lab at 20oC) 22.5 A5 -
DT90 (field) 28 A3 -
DT50 modelling endpoint - - -
Note EU 2016 dossier Lab studies DT50 range 0.6-20.8 days, DT90 range 2.6-110 days, Soils=15; field studies DT50 0.8-10.3 days, Soils=5
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 4.8 R3 -
Note Wheat, whole plant, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 25 A5 Slow
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note pH sensitive: DT50 4 days at pH 4, 31 days at pH 5, 365 days at pH 6 and pH 7, 362 days at pH 9, all at 20 degC
Water-sediment DT50 (days) 19 A5 Fast
Water phase only DT50 (days) 16 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 0.82 A5 Mobile
Kfoc 45
1/n 0.97
Notes and range EU dossier Kf range 0.12-2.47 mL/g, Kfoc range 0.8-152 mL/g, 1/n range 0.70-1.85, Soils=10
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-amino-4-methoxy-6-methyl-1,3,5-triazine (Ref: IN-A4098) This metabolite may cause environmental pollution, click here for further information Soil   0.409   Major fraction, Relevany unknown
methyl 2-(3- (4-hydroxy-6-methyl-1,3,5-triazin-2-yl)ureidosulfonyl) benzoate (Ref: AE-F161778) This metabolite may cause environmental pollution, click here for further information Soil   0.145   Major fraction, Relevany unknown
metsulfuron-methyl (Ref: DPX T6376) This metabolite may cause environmental pollution, click here for further information Soil   0.885   Major fraction, Relevany unknown
iodosulfuron Soil   -   Major fraction

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
1-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea
(Ref: AE 0000119)
- Surface water; Sediment - -
4-amino-6-(hydroxymethyl)-1,3,5-triazin-2-ol
(Ref: AE 0031838)
- Plant - -
-(4-methyl-6-oxo-1,6-dihydro-1,3,5-triazin-2-yl)urea
(Ref: AE 0034855)
- Surface water; Sediment - -
2-sulfamoylbenzoic acid
(Ref: AE 1234964)
- Soil; Surface water - -
methyl 2-(aminosulfonyl)-4-iodobenzoate
(Ref: AE F114368)
- Mammal - -
6-iodo-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
(Ref: AE F143133)
- Mammal - -
methyl 4-iodo-2-{[(4-methyl-6-oxo-1,6-dihydro-1,3,5-triazin-2-yl)carbamoyl]sulfamoyl}benzoate
(Ref: AE F145741)
- Plant; Soil; Sediment; Surface water - -
4-amino-6-methyl-1,3,5-triazin-2-ol
(Ref: AE F154781)
- Surface water; Sediment - -
1,2-benzothiazol-3(2H)-one 1,1-dioxide
(Ref: AE F159737)
- Surface water; Sediment - -
methyl 4-hydroxy-2-{[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]sulfamoyl}benzoate
(Ref: AE-0002166)
- (a) Water (Hydrolysis); =(b), Air (Photolysis) a= 0.182; b=0.666 -
2-amino-4-methoxy-6-methyl-1,3,5-triazine
(Ref: AE-F059411)
- (a) Soil, (b) Mammals (c) Plant a=0.409 -
methyl 2-{[(Ncarbamoylcarbamimidoyl)carbamoylcarbamimidoyl)benzoate
(Ref: BCS-CW81253)
- Soil; Surface water; Sediment - -


ECOTOXICOLOGY

for iodosulfuron-methyl-sodium

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 2448 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 7 A3 Dog High
(ppm diet) 200 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 100 A5 Lepomis macrochirus Low
Fish - Chronic 21 day NOEC (mg l-1) 10 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 100 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 10 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.00083 A5 Lemna gibba High
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.07 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 150 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 80 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 0
16
Mortality
Fertility
Dose: 0.01 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 3.4
29
Mortality
Fertility
Dose: 0.01 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.05 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for iodosulfuron-methyl-sodium

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 2448 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 2.81 A5 Rat, 4 hr (nose only, aerosol) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.03 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.05 A4 Dog, 90 day, SF=100 -
Dermal penetration studies (%) 10 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders or residents identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification NL - Not listed
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for iodosulfuron-methyl-sodium

Language Name
English iodosulfuron-methyl-sodium
French iodosulfuron
German Iodosulfuron-methyl-Natrium
Danish iodosulfuron-methyl-natrium
Italian iodosulfuron-metil-sodio
Spanish iodosulfuron-metil-sodio
Greek -
Slovenian jodosulfuron-metil-natrij
Polish jodosulfuron metylosodowy
Swedish jodsulfuronmetyl-natrium
Hungarian jodosulphuron-methyl-sodium
Dutch joodsulfuronmethylnatrium

Record last updated: Sunday 27 May 2018
Contact: aeru@herts.ac.uk