iodosulfuron-methyl-sodium (Ref: AE F115008) ** Translations

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SUMMARY

Iodosulfuron-methyl-sodium is a sulfonylurea herbicide approved for use in the EU. It is highly soluble in aqueous solution and semi-volatile. It is not persistent in soil but may be in aquatic systems. It is highly toxic to mammals, a neurotoxin and a skin, eye and respiratory tract irritant. It is moderately toxic to birds, most aquatic organisms, honeybees and earthworms.

GENERAL INFORMATION
for iodosulfuron-methyl-sodium

Description: A post-emergence herbicide used to control weeds in cereals and other crops

Example pests controlled: Grass; Broad-leaved weeds

Example applications: Cereals including wheat, barley, corn; Turf; Soybean

Efficacy & activity: Scientifically proven to be selective in cereals, acting against a broad spectrum of grass weeds and a range of dicot weeds.

Availability status: Current

Introduction & key dates: circa 2000

EC Regulation 1107/2009 (repealing 91/414):

Status	Approved
Dossier rapporteur/co-rapporteur	Sweden/Finland
Date inclusion expires	31/03/2032
EU Candidate for substitution (CfS)	No
Listed in EU database	Yes

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure:

Isomerism	-
Chemical formula	C14H13IN5NaO6S
Canonical SMILES	CC1=NC(=NC(=N1)OC)NC(=O)[N-]S(=O)(=O)C2=C(C=CC(=C2)I)C(=O)OC.[Na+]
Isomeric SMILES	No data
International Chemical Identifier key (InChIKey)	JUJFQMPKBJPSFZ-UHFFFAOYSA-M
International Chemical Identifier (InChI)	InChI=1S/C14H14IN5O6S.Na/c1-7-16-12(19-14(17-7)26-3)18-13(22)20-27(23,24)10-6-8(15)4-5-9(10)11(21)25-2;/h4-6H,1-3H3,(H2,16,17,18,19,20,22);/q;+1/p-1/fC14H13IN5O6S.Na/h20H;/q-1;m
2D structure diagram/image available?	Yes

General status:

Pesticide type	Herbicide
Substance group	Sulfonylurea
Minimum active substance purity	910 g/kg
Known relevant impurities	EU dossier - None declared
Substance origin	Synthetic
Mode of action	Selective to cereals. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS
CAS RN	144550-36-7
EC number	-
CIPAC number	634
US EPA chemical code	122021
PubChem CID	16760189
Molecular mass (g mol-1)	529.24
PIN (Preferred Identification Name)	-
IUPAC name	sodium ({[5-iodo-2-(methoxycarbonyl)phenyl]sulfonyl}carbamoyl)(4-methoxy-6-methyl-1,3,5-triazin-2-yl)azanide
CAS name	sodium salt of methyl 4-iodo-2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)benzoate
Other status information	-
Relevant Environmental Water Quality Standards	-
Herbicide Resistance Classification (HRAC)	B
Herbicide Resistance Classification (WSSA)	2
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	Not applicable
Examples of recorded resistance	Many recorded cases Avena fatua Phalaris mino Alopecurus myosuroides Papaver rhoeas Sinapis alba
Physical state	Beige coloured crystalline powder
Related substances & organisms	amidosulfuron mesosulfuron-methyl mefenpyr iodosulfuron

Formulations:

Property	Value
Example manufacturers & suppliers of products using this active now or historically	Bayer CropScience
Example products using this active	Atlantis WG Chekkar Hussar Othello Pacifica Sekator
UK LERAP status	Buffer probably required in UK - see product label
Formulation and application details	Often supplied as wettable granules that are mixed with water and used as a spray.

ENVIRONMENTAL FATE
for iodosulfuron-methyl-sodium

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		25000	A5	High
Solubility - In organic solvents at 20oC (mg l-1)		11	A5 - n-Heptane	-
		12	A5 - n-Hexane	-
		2100	A5 - Toluene	-
		12000	A5 - Methanol	-
Melting point (oC)		152	A5	-
Boiling point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		155	A5	-
Flashpoint (oC)		Not expected to self ignite; Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	2.00 X 10-01	Calculated	-
	Log P	-0.70	A5	Low
Bulk density (g ml-1)/Specific gravity		1.76	A5	-
Dissociation constant (pKa) at 25oC		3.22	A5	-
		Note: Strong acid
Vapour pressure at 20oC (mPa)		2.6 X 10-06	A5	Low volatility
Henry's law constant at 25oC (Pa m3 mol-1)		2.29 X 10-11	A5	Non-volatile
GUS leaching potential index		1.01	Calculated	Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	2.24 X 10-03	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Low
Maximum UV-vis absorption L mol-1 cm-1		In methanol: 291nm = 1471; [Methanol:NaOH (9:1): 291nm = 2073	A5	-
Surface tension (mN m-1)		72.0	A5 at 20 degC, 910 g/Kg	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
General biodegradability		-
Soil degradation (days) (aerobic)	DT50 (typical)	2.7	A5	Non-persistent
	DT50 (lab at 20oC)	2.7	A5	Non-persistent
	DT50 (field)	3.2	A5	Non-persistent
	DT90 (lab at 20oC)	22.5	A5	-
	DT90 (field)	28	A3	-
	DT50 modelling endpoint	-	-	-
	Note	EU 2016 dossier Lab studies DT50 range 0.6-20.8 days, DT90 range 2.6-110 days, Soils=15; field studies DT50 0.8-10.3 days, Soils=5
Dissipation rate RL50 on plant matrix	Value	-	-	-
	Note	-
Dissipation rate RL50 on and in plant matrix	Value	4.8	R3	-
	Note	Wheat, whole plant, n=1
Aqueous photolysis DT50 (days) at pH 7	Value	25	A5	Slow
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	A5	-
	Note	pH sensitive: DT50 4 days at pH 4, 31 days at pH 5, 365 days at pH 6 and pH 7, 362 days at pH 9, all at 20 degC
Water-sediment DT50 (days)		19	A5	Fast
Water phase only DT50 (days)		16	A5	Slow

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	-	-
	Koc	-
	Notes and range	-
Freundlich	Kf	0.82	A5	Mobile
	Kfoc	45
	1/n	0.97
	Notes and range	EU dossier Kf range 0.12-2.47 mL/g, Kfoc range 0.8-152 mL/g, 1/n range 0.70-1.85, Soils=10
pH sensitivity		No

Key metabolites:

Metabolite		Formation medium	Estimated maximum occurrence fraction	1107/2009 relevancy
2-amino-4-methoxy-6-methyl-1,3,5-triazine (Ref: IN-A4098)		Soil	0.409	Major fraction, Relevany unknown
methyl 2-(3- (4-hydroxy-6-methyl-1,3,5-triazin-2-yl)ureidosulfonyl) benzoate (Ref: AE-F161778)		Soil	0.145	Major fraction, Relevany unknown
metsulfuron-methyl (Ref: DPX T6376)		Soil	0.885	Major fraction, Relevany unknown
iodosulfuron		Soil	-	Major fraction

Other known metabolites:

Metabolite name and reference	Aliases	Formation medium / Rate	Estimated maximum occurrence fraction	Metabolising enzymes
1-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea (Ref: AE 0000119)	-	Surface water; Sediment	-	-
4-amino-6-(hydroxymethyl)-1,3,5-triazin-2-ol (Ref: AE 0031838)	-	Plant	-	-
-(4-methyl-6-oxo-1,6-dihydro-1,3,5-triazin-2-yl)urea (Ref: AE 0034855)	-	Surface water; Sediment	-	-
2-sulfamoylbenzoic acid (Ref: AE 1234964)	-	Soil; Surface water	-	-
methyl 2-(aminosulfonyl)-4-iodobenzoate (Ref: AE F114368)	-	Mammal	-	-
6-iodo-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (Ref: AE F143133)	-	Mammal	-	-
methyl 4-iodo-2-{[(4-methyl-6-oxo-1,6-dihydro-1,3,5-triazin-2-yl)carbamoyl]sulfamoyl}benzoate (Ref: AE F145741)	-	Plant; Soil; Sediment; Surface water	-	-
4-amino-6-methyl-1,3,5-triazin-2-ol (Ref: AE F154781)	-	Surface water; Sediment	-	-
1,2-benzothiazol-3(2H)-one 1,1-dioxide (Ref: AE F159737)	-	Surface water; Sediment	-	-
methyl 4-hydroxy-2-{[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]sulfamoyl}benzoate (Ref: AE-0002166)	-	(a) Water (Hydrolysis); =(b), Air (Photolysis)	a= 0.182; b=0.666	-
2-amino-4-methoxy-6-methyl-1,3,5-triazine (Ref: AE-F059411)	-	(a) Soil, (b) Mammals (c) Plant	a=0.409	-
methyl 2-{[(Ncarbamoylcarbamimidoyl)carbamoylcarbamimidoyl)benzoate (Ref: BCS-CW81253)	-	Soil; Surface water; Sediment	-	-

ECOTOXICOLOGY
for iodosulfuron-methyl-sodium

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF (l kg-1)	Low risk	A5 Based on LogP < 3	Low potential
	CT50 (days)	-		-
Mammals - Acute oral LD50 (mg kg-1)		2448	A5 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	7	A3 Dog	High
	(ppm diet)	200		-
Birds - Acute LD50 (mg kg-1)		> 2000	A5 Colinus virginianus	Low
Birds - Short term dietary (LC50/LD50)		> 5000 mg kg feed-1	A5 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		> 100	A5 Lepomis macrochirus	Low
Fish - Chronic 21 day NOEC (mg l-1)		10	A5 Oncorhynchus mykiss	Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		> 100	A5 Daphnia magna	Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		10	A5 Daphnia magna	Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		0.00083	A5 Lemna gibba	High
Non-target plants		-	-	-
		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		0.07	A5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees	Contact acute 48 hour LD50 (μg bee-1)	> 150	A5	Low
	Oral acute 48 hour LD50 (μg bee-1)	> 80	A5	Moderate
	Unknown mode acute 48 hour LD50 (μg bee-1)	-	-	-
Earthworms - Acute 14 day LC50 (mg kg-1)		> 1000	A5 Eisenia foetida	Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50 / EC50 / NOEC / % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	0 16	Mortality Fertility Dose: 0.01 kg ha-1 A5 Aphidius rhopalosiphi, adult	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	3.4 29	Mortality Fertility Dose: 0.01 kg ha-1 A5 Typhlodromus pyri, protonymph	-
Soil micro-organisms		Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect	A5 Dose: 0.05 kg ha-1	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION
for iodosulfuron-methyl-sodium

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		High (class III)	-	-
Mammals - Acute oral LD50 (mg kg-1)		2448	A5 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 2.81	A5 Rat, 4 hr (nose only, aerosol)	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.03	A5 Rat, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		None allocated	A5	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.05	A4 Dog, 90 day, SF=100	-
Dermal penetration studies (%)		10	A5	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	No unacceptable risks to bystanders or residents identified
	Occupational	No unacceptable risks to operators or other workers identified
European MRLs		Click here for the EU MRL pesticide database
Drinking Water Standards		-	-	-
Drinking Water MAC (μg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Cholinesterase inhibitor	Neurotoxicant
Respiratory tract irritant	Skin irritant	Skin sensitiser	Eye irritant	Phototoxicant
General human health issues		No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		Not explosive or oxidising IMDG Transport Code is usually 9
CLP classification 2013		Environment: H400, H410
EC Risk Classification		N - Dangerous for the environment: R50, R53
EC Safety Classification		S60, S61
WHO Classification		NL	-	Not listed
US EPA Classification (formulation)		No consensus across products or no products available	-	-
UN Number		Usually 3077
Waste disposal & packaging		Packaging Group III (minor danger)

TRANSLATIONS
for iodosulfuron-methyl-sodium

Language	Name
English	iodosulfuron-methyl-sodium
French	iodosulfuron
German	Iodosulfuron-methyl-Natrium
Danish	iodosulfuron-methyl-natrium
Italian	iodosulfuron-metil-sodio
Spanish	iodosulfuron-metil-sodio
Greek	-
Slovenian	jodosulfuron-metil-natrij
Polish	jodosulfuron metylosodowy
Swedish	jodsulfuronmetyl-natrium
Hungarian	jodosulphuron-methyl-sodium
Dutch	joodsulfuronmethylnatrium

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Record last updated: Sunday 27 May 2018
Contact: aeru@herts.ac.uk