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lenacil (Ref: DPX B634)
** lenacile ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Lenacil is a diazine herbicide for selective weed control that is approved for use in the EU. It has a low solubility in water, has a high risk of leaching to groundwater based on its chemical properties and is semi-volatile. It is moderately persistent in soil and will persist in aquatic systems. It is not greatly toxic to mammals and is a known irritant but no other significant human health issues have been identified. It is moderately toxic to birds, most aquatic organisms, honeybees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for lenacil

Description: A soil-acting herbicide for the control of weeds in beet and other crops

Example pests controlled: Annual grasses; Broad-leaved weeds

Example applications: Sugarbeet; Red beet; Fodder beet; Mangels; Sugarcane; Ornamentals; Currants; Gooseberries

Efficacy & activity: -

Availability status: Current

Introduction & key dates: circa 1965

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Belgium/Austria
Date inclusion expires 31/12/2018
EU Candidate for substitution (CfS) Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None
Chemical formula C13H18N2O2
Canonical SMILES C1CCC(CC1)N2C(=O)C3=C(CCC3)NC2=O
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) ZTMKADLOSYKWCA-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C13H18N2O2/c16-12-10-7-4-8-11(10)14-13(17)15(12)9-5-2-1-3-6-9/h9H,1-8H2,(H,14,17)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Uracil
Minimum active substance purity 975 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Selective, systemic absorbed by roots and having residual effect. Inhibits photosynthesis (photosystem II).
CAS RN 2164-08-1
EC number 218-499-0
CIPAC number 163
US EPA chemical code 525200
PubChem CID 16559
Molecular mass (g mol-1) 234.29
PIN (Preferred Identification Name) -
IUPAC name 3-cyclohexyl-1,5,6,7-tetrahydrocyclopentapyrimidine-2,4(3H)-dione
CAS name 3-cyclohexyl-6,7-dihydro-1H-cyclopentapyrimidine-2,4(3H,5H)-dione
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) C1
Herbicide Resistance Classification (WSSA) 5
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White to tan coloured crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Clayton
  • DuPont
  • Fahlberg-List
Example products using this active
  • Safari Lite
  • Venzar Flowable
  • Lenazar Flo
  • Elbatan
UK LERAP status None
Formulation and application details Often supplied as soluble concentrate or wettable powder.


ENVIRONMENTAL FATE

for lenacil

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 2.9 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 690 A5 - Acetone -
80 A5 - Toluene -
1.3 A5 - Hexane -
500 A5 - Ethyl acetate -
Melting point (oC) Decomposes before melting A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 270 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 4.90 X 1001 Calculated -
Log P 1.69 A5 Low
Bulk density (g ml-1)/Specific gravity 1.32 L3 -
Dissociation constant (pKa) at 25oC 10.7 A5 -
Note: Very weak acid
Vapour pressure at 20oC (mPa) 1.7 X 10-06 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.3 X 10-07 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.18 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.60 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 271nm = 7880, 290nm = 1760; [Acidic solution: 271nm = 7990, 290nm = 1760; [Basic solution, 227nm = 7220, 291nm = 1760 A5 -
Surface tension (mN m-1) 62.5 A5 at 24oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 179 K4 Persistent
DT50 (lab at 20oC) 14.4 A5 Non-persistent
DT50 (field) 39.8 A5 Moderately persistent
DT90 (lab at 20oC) 53.2 A5 -
DT90 (field) 131.8 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 11-18 days, DT90 range 37-83 days, field studies DT50 range 18-88 days, DT90 range 61-291 days; Other sources: DT50 range 35-200 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 9 for over 1 year
Water-sediment DT50 (days) 112 A5 Slow
Water phase only DT50 (days) 91 K4 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - Q3 Moderately mobile
Koc 165
Notes and range Literature range 75-254 mL/g
Freundlich Kf 2.39 A5 Moderately mobile
Kfoc 130
1/n 0.89
Notes and range EU dossier kf range 0.35-7.87, Kfoc range 75-254 mL/g, 1/n range 0.86-0.94, Soils=7
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
3-cyclohexyl-6,7-dihydro-7-1H-cyclopentapyrimidine-2,4,5-(3H)trione (Ref: IN-KE121) This metabolite may cause environmental pollution, click here for further information Soil   0.139   Major fraction, Relevancy unknown
3-cyclohexyl-6,7-dihydroxy-7-1H-cyclopentapyrimidine-2,4,5(3H)trione (Ref: IN-KF313) This metabolite may cause environmental pollution, click here for further information Soil   0.147   Major, Relevancy unknown

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: IN-KC943) 7-hydroxy lenacil Soil; Plant - -
(Ref: IN-KD302) - Soil - -
(Ref: IN-KQ961) - Water (Photolysis) - -


ECOTOXICOLOGY

for lenacil

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 18 Q2 Estimated Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 1088 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 2.0 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 2.3 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 8.4 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.48 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.019 A5 Lemna gibba Moderate
Non-target plants 427 A5 Lycopersicon esculentum
Vegetative vigour, ER50
as g/ha
-
177.2 A5 Brassica napus
Seedling emergence, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 0.0077 A5 Pseudokirchneriella subcapitata High
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.01 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 25 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 100 A4 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 2000 >
A5 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 2000 >
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 5.0 kg ha-1; 28 days
-
Mesocosm study data NOEAEC mg l-1 0.0221 A5 Macrophytes, zooplankton and phytoplankton -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for lenacil

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 5.12 A5 Rat, 4 hr (nose only, aerosol) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.12 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.4 A5 -
Dermal penetration studies (%) 1.0-15.5 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Negligible risk for bystanders
Occupational Potential risk of exposure to operators
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number Variable with product, usually 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for lenacil

Language Name
English lenacil
French lenacile
German Lenacil
Danish lenacil
Italian lenacil
Spanish lenacilo
Greek -
Slovenian lenacil
Polish lenacyl
Swedish -
Hungarian lenacil
Dutch lenacil

Record last updated: Thursday 13 September 2018
Contact: aeru@herts.ac.uk