Metalaxyl (Ref: CGA 48988) |
![]() Last updated: 12/01/2021 |
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(Not known by any other names) |
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A fungicide used to control diseases caused by air- and soil-borne Peronosporales in many different crops | |
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Downy mildew; Foliar and tuber blight; Damping-off | |
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Many agricultural crops including tobacco, potaoes, soybean, onions, citrus, cucubits, tomatoes, cotton; Ornamentals; Turf | |
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Current | |
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1977, first reported; 1979, first marketed |
UK regulatory status |
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Not approved | ||
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30/06/2026 | ||
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Buffer probably required in UK - see product label |
EC Regulation 1107/2009 (repealing 91/414) |
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Approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Spain/Portugal | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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30/06/2023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes - non-active isomers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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Australia, USA |
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Chemical structure |
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A chiral molecule that exists in the R- and S-forms | |
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C₁₅H₂₁NO₄ | |
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CC1=C(C(=CC=C1)C)N(C(C)C(=O)OC)C(=O)COC | |
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No data | |
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ZQEIXNIJLIKNTD-UHFFFAOYSA-N | |
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InChI=1S/C15H21NO4/c1-10-7-6-8-11(2)14(10)16(13(17)9-19-4)12(3)15(18)20-5/h6-8,12H,9H2,1-5H3 | |
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Yes |
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Common Name | Relationship | Link |
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metalaxyl | Unstated isomer | ![]() |
General status |
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Fungicide | |
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Phenylamide | |
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950 g kg⁻¹ | |
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EU dossier: 2,6-dimenthylaniline < 1 g kg⁻¹ | |
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Synthetic | |
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Systemic with curative and protective action, acts by suppressing sporangial formation, mycelial growth and the establishment of new infectons. Disrupts fungal nucleic acid synthesis - RNA ploymerase 1. | |
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57837-19-1 | |
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260-979-7 | |
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365 | |
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113501 | |
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42586 | |
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279.33 | |
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methyl N-(methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate | |
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methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)-DL-alaninate | |
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Potential groundwater contaminant | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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4 | |
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Colourless to white fine crystals |
Formulations |
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Foliar application. Available in a variety of different formulations including granules, wettable powders and emulsifiable concentrates. |
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8400 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) at 22 °C pH 5.24 = Verified data |
High | ||||||||
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550000 | C4 C = AGRITOX (click here ) Benzene4 = Verified data |
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9100 | C4 C = AGRITOX (click here ) Hexane4 = Verified data |
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650000 | C4 C = AGRITOX (click here ) Methanol4 = Verified data |
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Miscible | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Toluene5 = Verified data used for regulatory purposes |
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72.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Not expected to self ignite; Not highly flammable | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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5.62 X 1001 | Calculated | - | |||||||
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1.75 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) at 25 °C4 = Verified data |
Low | ||||||||
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1.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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0 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Very strong acid | |||||||||||
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0.75 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility | ||||||||
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1.60 X 10-05 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-volatile | ||||||||
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Max at 206nm No absorption > 290nm |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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36 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately persistent | |||||||
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7.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | ||||||||
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14.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | ||||||||
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28.9 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | ||||||||
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46.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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EU dossier Lab studies DT₅₀ range 2.6-73 days (normalised), DT₉₀ range 13-87 days; Field studties DT₅₀ range 4.6-31 days, Dt90 range 15-102 days; Other sources: DT₅₀ 70 days (DW4) | ||||||||||
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9.2 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Published literature RL₅₀ range 2.5-16.0 days, 3 field & undercover grown crops, various matrices, n=3 | ||||||||||
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5.7 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Published literature RL₅₀ range 0.8-22.5 days, 16 field & undercover crops, various matrices, n=31; Lab study with bentgrass, RL₅₀=100 days | ||||||||||
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Stable | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Stable | |||||||
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106 | K4 K = Research datasets, e.g. Pandora, Demetra 4 = Verified data |
Persistent | |||||||
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pH sensitive: DT₅₀ 200 days at pH 1, 115 days at pH 9, 12 days at pH 10, all at 20 °C | ||||||||||
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56 | K4 K = Research datasets, e.g. Pandora, Demetra 4 = Verified data |
Moderately fast | ||||||||
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56 | K4 K = Research datasets, e.g. Pandora, Demetra 4 = Verified data |
Stable |
Soil adsorption and mobility |
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- | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately mobile | |||||||
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162 | ||||||||||
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2.49 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately mobile | |||||||
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162.3 | ||||||||||
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0.98 | ||||||||||
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EU dossier Kf range 0.4-1.4 mL g⁻¹, Kfoc range 29.6-283.8 mL g⁻¹, 1/n range 0.766-1.257, Soils=4; Literature data: Kf range 0.01-8.01 mL g⁻¹, Kfoc range 28-284 mL g⁻¹, 1.n range 0.57-1.32, Soils = 27 | ||||||||||
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Fate indices |
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2.06 | Calculated | Transition state | ||||||||||||||||||||||||||
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5.61 X 10-02 | Calculated | - | |||||||||||||||||||||||||
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Low | Calculated | - | ||||||||||||||||||||||||||
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Moderately mobile | Calculated | - |
Key metabolites |
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Soil | 0.536 | - |
Other known metabolites |
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2,6-dimethylacetanilide | - | Soil (Aerobic) | - | - | |||||
N-(3-hydroxy-2,6-dimethylphenyl)-N-(methoxyacetyl)-L-alanine | - | Water (Anaerobic) | - | - |
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7 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Whole fish4 = Verified data |
Low potential | |||||||
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Not available | - | |||||||||
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> 669 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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2.5 | Z2 Z = Kingtai Chemials website (click here ) Rat2 = Unverified data of unknown source |
High | |||||||
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> 96 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat Reproductive NOAEL5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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1466 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Anas platyrhynchos5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 10000 mg kg feed⁻¹ | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Anas platyrhynchos5 = Verified data used for regulatory purposes |
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24.6 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Anas platyrhynchos5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.96 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Oncorhynchus mykiss5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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3.47 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 1.0 | P4 P = Other governments and regulators Daphnia magna4 = Verified data |
Moderate | ||||||||
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0.64 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Americamysis bahia3 = Unverified data of known source |
Moderate | ||||||||
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85 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Lemna gibba3 = Unverified data of known source |
Low | ||||||||
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0.42 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Scenedemus subspicatus5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 20 | P4 P = Other governments and regulators Chlorella pyrenoidosa4 = Verified data |
Low | ||||||||
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200 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low | |||||||
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269 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 1000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida5 = Verified data used for regulatory purposes |
Low | ||||||||
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40 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida as metalaxyl-M3 = Unverified data of known source |
Moderate | ||||||||
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630 | as g product ha⁻¹ (Armetil Cobre: Conc 8% metalaxyl) A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Typhlodromus pyri5 = Verified data used for regulatory purposes |
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380 | as g product ha⁻¹ (Armetil Cobre: Conc 8% metalaxyl) A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Aphidius rhopalosiphi5 = Verified data used for regulatory purposes |
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Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effe |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Dose: 5.0 kg ha⁻¹ |
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General |
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High (class III) | - | - | ||||||||
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> 669 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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5000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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> 3.6 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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0.08 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Dog SF=1005 = Verified data used for regulatory purposes |
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0.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
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0.08 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
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30 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Moderately toxic Liver toxicant Not listed as a skin sensitiser in the EU but some evidence available suggesting it may be exists elsewhere A weak inducer of cytochrome P450 |
Handling issues |
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Not explosive | |||
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Health: H302; H317 Environment: H412 |
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Xn - Harmful: R22, R43 N - Dangerous for the environment: R52, R53 |
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S2, S13, S24, S37, S46, S61 | |||
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II (Moderately hazardous) | |||
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metalaxyl | ||
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metalaxyl | ||
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Metalaxyl | ||
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metalaxyl | ||
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metalaxil | ||
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metalaxil | ||
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metalaxyl | ||
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metalaksyl | ||
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metalaxyl | ||
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metalaxyl | ||
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metalaxyl |
Record last updated: | 12/01/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |