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methiocarb (Ref: OMS 93)
** mercaptodimethur ** ENT 25726 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Methiocarb is a carbamate pesticide currently approved for use in the EU. It has a low aqueous solubility, low volatility and, based on its chemical properties, it would not normally be expected to leach to groundwater. However, it has been detected in several countries. It is not normally persistent in soil or water systems. It is highly toxic to mammals, a cholinesterase inhibitor and a neurotoxin. It is also highly toxic to most fauna and flora including honey bees. The main exception is earthworms where the toxicity appears to be low.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for methiocarb

Description: A molluscicide and insecticide for control of a variety of plant pests. It also has application as a pheasant repellent.

Example pests controlled: Slugs and snails; Birds; Fruit flies; Mites; Leafhoppers; Aphids; Psylla, Meallybugs; Scale insects; Thrips; Some soil pests

Example applications: Most agricultural crops including maize, oilseed rape, pulses, root & tuber crops, lettuce; Fruit including cherries, blueberries, peaches

Efficacy & activity: Efficiacy is supported by long-term use across Europe and experimental work in various EU countries.

Availability status: Current

Introduction & key dates: 1962 first introduced; first registered as a pesticide in the US in 1972

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK/Germany
Date inclusion expires 31/07/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None
Chemical formula C11H15NO2S
Canonical SMILES CC1=CC(=CC(=C1SC)C)OC(=O)NC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) YFBPRJGDJKVWAH-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C11H15NO2S/c1-7-5-9(14-11(13)12-3)6-8(2)10(7)15-4/h5-6H,1-4H3,(H,12,13)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Molluscicide, Bird repellent
Substance group Carbamate
Minimum active substance purity 980 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Non-systemic with neurotoxic contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 2032-65-7
EC number 217-991-2
CIPAC number 165
US EPA chemical code 100501
PubChem CID 16248
Molecular mass (g mol-1) 225.31
PIN (Preferred Identification Name) -
IUPAC name 4-methylthio-3,5-xylyl methylcarbamate
CAS name 3,5-dimethyl-4-(methylthio)phenyl methylcarbamate
Other status information Potential groundwater contaminant - previously detected in US, Australia, Mexico and Spain; Not approved for use as pelleted molluscicide in the EU.
Relevant Environmental Water Quality Standards UK Environment Agency non-statutory standard for the protection of aquatic life in freshwater and saltwater annual average 0.01 ug/L, max acceptable conc 0.16 ug/L
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Frankliniella occidentalis
Physical state Colourless crystals
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
  • Interfarm
  • Mobay
Example products using this active
  • Decoy
  • Draza
  • Exit Wetex
  • Huron
  • Karan
  • Rivet
  • Mesurol
UK LERAP status None
Formulation and application details Often supplied for use as a seed treatment but also available as pellets or granules and applied directly to soil surface.


ENVIRONMENTAL FATE

for methiocarb

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 27 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 20000 A5 - Xylene -
144000 A5 - Acetone -
87000 A5 - Ethyl acetate -
31000 A5 - 1-Octanol -
Melting point (oC) 118.5 A5 -
Boiling point (oC) 311 A5 -
Degradation point (oC) 300 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.51 X 1003 Calculated -
Log P 3.18 A5 High
Bulk density (g ml-1)/Specific gravity 1.25 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 1.50 X 10-02 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.20 X 10-04 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.55 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.50 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 pH 7: 203nm=44762, 223nm=12021, 267nm=2582
pH 2: 203nm=52548, 223nm=13026, 267nm=3030
pH 10: 219nm=23298, 267nm=11461
A5 -
Surface tension (mN m-1) 72.0 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Not likely to be readily biodegradable
Soil degradation (days) (aerobic) DT50 (typical) 2.94 A5 Non-persistent
DT50 (lab at 20oC) 2.94 A5 Non-persistent
DT50 (field) 35 B5 Moderately persistent
DT90 (lab at 20oC) 12.08 A5 -
DT90 (field) - - -
DT50 modelling endpoint 1.4 A5 normalised geometric mean -
Note EU 2017 dossier lab studies DT50 range 0.5-11.3 days, DT90 range 1.7-48.1 days, Soils=5; Other sources: 30 days (DW4)
Dissipation rate RL50 on plant matrix Value 8.0 R4 -
Note Published literature RL50 range 1.7-11.5 days, 2 field & undercover growncrops, various matrices, n=3
Dissipation rate RL50 on and in plant matrix Value 2.4 R4 -
Note Published literature RL50 range 2.35-2.40 days, 2 undercover grown crops, various matrices, n=2
Aqueous photolysis DT50 (days) at pH 7 Value 11 A5 Moderately fast
Note DT50 6 - 16 days for range of environmental scenarios
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 24 A5 Non-persistent
Note pH sensitive: DT50 321 days at pH 5, 0.21 days at pH 9, all at 25 degC
Water-sediment DT50 (days) 4.0 A5 Fast
Water phase only DT50 (days) 1.6 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 5.88 A5 Slightly mobile
Kfoc 660
1/n 0.832
Notes and range EU 2017 dossier Kf range 0.43-0.9 mL/g, Kfoc range 408-1000 mL/g, 1/n range 0.81-0.87, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
methiocarb sulfoxide This metabolite may cause environmental pollution, click here for further information Soil   0.588   Major fraction, Relevant
methiocarb sulfoxide phenol This metabolite may cause environmental pollution, click here for further information Soil   0.360   Major fraction, Relevant
methiocarb sulfone phenol This metabolite may cause environmental pollution, click here for further information Soil   0.198   Major fraction, Relevant
methiocarb methoxy sulfone This metabolite may cause environmental pollution, click here for further information Soil   0.132   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
- methiocarb phenol; methiocab metabolite M03 Plant - -


ECOTOXICOLOGY

for methiocarb

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 75 A5 Lepomis macrochirus Low potential
CT50 (days) 1 -
Mammals - Acute oral LD50 (mg kg-1) 19 A5 Rat High
Mammals - Short term dietary NOEL (mg kg-1) 1.3 B5 Rat High
(ppm diet) 10 -
Birds - Acute LD50 (mg kg-1) 5 A5 Coturnix japonica High
Birds - Short term dietary (LC50/LD50) 1071 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 0.65 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.05 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.008 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0001 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 2.2 A5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 3.2 Q2 Unknown species Low
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.23 A5 Apis mellifera High
Oral acute 48 hour LD50 (μg bee-1) 0.08 A5 Apis mellifera High
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 1322 A5 Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 0.32 A3 Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 0.47 48 hour
A5 Aphidius rhopalosiphi, adult
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 33.7 7 day
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 1.47 mg kg-1 soil, 28days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for methiocarb

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 19 A5 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 0.433 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.013 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.013 A5 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) 0.016 A5 Rat, Sf=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.013 A5 Dog, SF=100 -
Dermal penetration studies (%) 1-2 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Negligible risk to bystanders as pesticide used normally as a seed dressing
Occupational Negligible risk to operators
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Endocrine issues - Inhibition of androgen activity and increase of estrogen one,

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 health, H300, H301, H330
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R25
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S22, S37, S45, S60, S61
WHO Classification Ib - Highly hazardous
US EPA Classification (formulation) I - Danger - Highly toxic
UN Number 2757
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for methiocarb

Language Name
English methiocarb
French methiocarb
German Methiocarb
Danish mercaptodimethur
Italian metiocarb
Spanish metiocarb
Greek mercaptodimethur
Slovenian metiokarb
Polish metiokarb
Swedish metiokarb
Hungarian mercaptodimethur
Dutch metiocarb

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk