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metolachlor (Ref: CGA 24705)
** metolachlore ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for metolachlor

Description: A pre-emergence herbicide used to control certain weeds in a variety of situations

Example pests controlled: Broad-leaved; Annual grassy weeds

Example applications: Corn; Soybeans; Sorghum; Potatoes; Cotton; Safflower; Stone fruits; Nuts; Woody ornamentals

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1976

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires -
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A molecule with two chiral centres. The technical product is an isomeric mixture containing both the R- and S-enantiomers
Chemical formula C15H22ClNO2
Canonical SMILES CCC1=CC=CC(=C1N(C(C)COC)C(=O)CCl)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) WVQBLGZPHOPPFO-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C15H22ClNO2/c1-5-13-8-6-7-11(2)15(13)17(14(18)9-16)12(3)10-19-4/h6-8,12H,5,9-10H2,1-4H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Chloroacetamide
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Selective, reduces seed germination. Inhibition of VLCFA (inhibition of cell division).
CAS RN 51218-45-2
EC number 257-060-8
CIPAC number 400
US EPA chemical code 108801
PubChem CID 4169
Molecular mass (g mol-1) 283.8
PIN (Preferred Identification Name) -
IUPAC name 2-chloro-N-(6-ethyl-o-tolyl)-N-[(1RS)-2-methoxy-1-methylethyl]acetamide
CAS name 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide
Other status information Potential groundwater contaminant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) K3
Herbicide Resistance Classification (WSSA) 15
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Lolium rigidum
Physical state Off-white to colourless liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Ciba-Geigy
Example products using this active
  • Dual
  • Bicep
  • Pennant
  • Pimagram
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually formulated as an emulsifiable concentrate.


ENVIRONMENTAL FATE

for metolachlor

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 530 G4 High
Solubility - In organic solvents at 20oC (mg l-1) Miscible L3 - Benzene -
Miscible L3 - Acetone -
Miscible L3 - Hexane -
Miscible L3 - Xylene -
Melting point (oC) -62.1 L3 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) 190 L3 -
Octanol-water partition coefficient at pH 7, 20oC P 2.51 X 1003 Calculated -
Log P 3.4 G4 High
Bulk density (g ml-1)/Specific gravity 1.12 L3 -
Dissociation constant (pKa) at 25oC Not applicable R4 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 1.7 G4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.40 X 10-03 L3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.10 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.19 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 90 DW4 Moderately persistent
DT50 (lab at 20oC) 15 L3 Non-persistent
DT50 (field) 21 L3 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note General literature lab studies DT50 range 8-38 days, field studies DT50 range 11-31 days (Switerland and France): Other sources: DT50 6-100 days (R3), 26 days @ 25 DegC (R4
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 9.1 R4 -
Note Published literature RL50 range 1.0-17.4 days, 3 field & undercover grown crops, various matrices, n=3
Aqueous photolysis DT50 (days) at pH 7 Value Stable Q2 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable Q2 -
Note -
Water-sediment DT50 (days) 365 Q2 Stable
Water phase only DT50 (days) 88 Q2 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 0.67 R4 Moderately mobile
Koc 120
Notes and range Literature value: Kd range 0.33-1.64 mL/g, Koc range 50.0-540 mL/g, soils=33; Other sources: 120.2-309.0 mL/g (R3), Log Koc 2.26 at 25 Deg C (R4)
Freundlich Kf 0.93 R4 Moderately mobile
Kfoc 163
1/n 0.888
Notes and range Literature values: Study 1 - Kf range 0.07-2.57 mL/g, Kfoc range 51.7-600 mL/g, 1/n range 0.55-1.35, Soils=36; study 2 - Kf range 4.8-26.7 mL/g, Kfoc range 421-3679 mL/g, 1/n range 0.47-1.10, soils=5 (R4)
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
metolachlor oxanilic acid (Ref: CGA 51202) This metabolite may cause environmental pollution, click here for further information Soil   0.1   Major fraction, Relevant
metolachlor ethane sulfonic acid (Ref: CGA 354743) This metabolite may cause environmental pollution, click here for further information Soil   0.1   Major fraction, Relevant


ECOTOXICOLOGY

for metolachlor

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 68.8 Q3 Whole fish Low potential
CT50 (days) 1.5 -
Mammals - Acute oral LD50 (mg kg-1) 1200 G4 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 90 G4 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 2000 G4 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 3.9 G4 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 23.5 G4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.707 F3 Daphnia magna, LOEC Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 4.2 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.043 F3 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 57.1 F4 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 110 F4 Apis mellifera Low
Oral acute 48 hour LD50 (μg bee-1) 110 F4 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 140 G4 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for metolachlor

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1200 G4 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 5050 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) 2.02 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.1 L3 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards Non-statutory WHO drinking water guideline 0.01 mg/L UK EA QS database, 2018 -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues May cause convulsions, diarrhea, jaundice, weakness, nausea, sweating and dizziness
USEPA - possible human carcinogen
Endocrine issues - Pregnane X cellular receptor activation

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R43
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S24, S37, S60, S61
WHO Classification III - Slightly hazardous
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for metolachlor

Language Name
English metolachlor
French metolachlore
German Metolachlor
Danish metolachlor
Italian metolaclor
Spanish metolacloro
Greek metolachlor
Slovenian metolaklor
Polish metolachlor
Swedish -
Hungarian metolachlor
Dutch metolachloor

Record last updated: Wednesday 23 May 2018
Contact: aeru@herts.ac.uk