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metosulam (Ref: XDE 511)
** metosulame ** DE 511 ** XRD 511 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for metosulam

Description: A post-emergence, broad-spectrum foliar herbicide used to control broad-leaved weeds in cereals and other crops

Example pests controlled: Broad-leaved weeds

Example applications: Cereals; Grain legumes; Pasture; Alfaalfa; Rice

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1993, first reported; 1994, launched Turkey

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Norway
Date inclusion expires 30/04/2021
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C14H13Cl2N5O4S
Canonical SMILES CC1=C(C(=C(C=C1)Cl)NS(=O)(=O)C2=NN3C(=CC(=NC3=N2)OC)OC)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) VGHPMIFEKOFHHQ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H13Cl2N5O4S/c1-7-4-5-8(15)12(11(7)16)20-26(22,23)14-18-13-17-9(24-2)6-10(25-3)21(13)19-14/h4-6,20H,1-3H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Triazolopyrimidine
Minimum active substance purity 980 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Selective, absorbed by roots and shoots. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS.
CAS RN 139528-85-1
EC number 410-240-1
CIPAC number 707
US EPA chemical code -
PubChem CID 86422
Molecular mass (g mol-1) 418.26
PIN (Preferred Identification Name) -
IUPAC name 2',6'-dichloro-5,7-dimethoxy-3'-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonanilide
CAS name N-(2,6-dichloro-3-methylphenyl)-5,7-dimethoxy[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) B
Herbicide Resistance Classification (WSSA) 2
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Echium plantagineum
Raphanus raphanistrum
Physical state Cream powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
Example products using this active
  • Tacco SC100
  • Metosulam SC100
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Usually supplied as a suspension concentrate that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for metosulam

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 700 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 7800 A5 - Acetone -
1000 A5 - Ethyl acetate -
1900 A5 - Methanol -
200 A5 - Toluene -
Melting point (oC) Decomposes before melting A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 190 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.58 X 1000 Calculated -
Log P 0.2 A5 Low
Bulk density (g ml-1)/Specific gravity 1.49 B5 -
Dissociation constant (pKa) at 25oC 5.5 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 1.0 X 10-09 A4 - 25 degC Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 8.00 X 10-13 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.62 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.73 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral sol: 212nm = 67000; [Acid sol: 206nm = 55000; [Basic sol: 212nm = 71000 A5 -
Surface tension (mN m-1) 69.6 A5 at 20oC, 96% -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 19 B5 Non-persistent
DT50 (lab at 20oC) 8.1 A5 Non-persistent
DT50 (field) 38.8 A5 Moderately persistent
DT90 (lab at 20oC) 54 A5 -
DT90 (field) 112 A4 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 4.2-33.3 days, DT90 range 16.3-144 days; field studies DT50 range 20-47 days, DT90 range 660-156 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 31.1 A5 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 9, 25 degC, 30 days
Water-sediment DT50 (days) 8.2 A5 Fast
Water phase only DT50 (days) 6.7 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 3.61 A5 Moderately mobile
Kfoc 166
1/n 0.921
Notes and range EU dossier kf range 0.927-8.841, kfoc range 51.5-264.7 mL/g, 1/n range 0.843-1.084, Soils=4
pH sensitivity Adsorption increase as soils pH decreases

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
5-amino-N-(2,6-dichloro-3-methylphenyl)-1H-1,2,4-triazole-3-sulfonamide This metabolite may cause environmental pollution, click here for further information Soil   0.263   Major fraction, Relevancy unknown
N-(2,6-dichloro-3-methylphenyl)-5-methoxy-7-hydroxy-1,2,4-triazolo(1,5-alpha)pyrimidine-2-sulfonamide This metabolite may cause environmental pollution, click here for further information Soil   0.218   Major fraction, Relevancy unknown

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
- 5,7-OH-metosulam Soil - -
- 4-OH-metosulam sulphate; metosulam metabolite M11 Rat - -
- 4-OH-metosulam gucoside; metosulam metabolite M08 Rat - -


ECOTOXICOLOGY

for metosulam

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 10 B5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 1923 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) > 29.3 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 24.4 A5 Oncorhynchus mykiss Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 100 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 2.5 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.0023 A5 Lemna gibba High
Non-target plants 4.89 A5 rape
Seedling emergence, ER50
as g/ha
-
1.46 A5 Tomato
Vegetative vigour, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 0.075 A5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 40.0 >
A5 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 40.0 >
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for metosulam

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 1.9 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.05 A3 Rat, SF=100, proposed -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.25 A2 Dog, SF=100, proposed -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.02 A3 Dog, SF=200, proposed -
Dermal penetration studies (%) 0.02-4.3 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Negligible risk to bystanders
Occupational Protective clothing required to mitigate risks to operators
No foreseen risks to other workers
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible kidney and gall bladder toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H373, H351
EnvironmentL H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Xn - Harmful: R48/22
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) - -
UN Number Usually 3077]
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for metosulam

Language Name
English metosulam
French metosulam
German Metosulam
Danish metosulam
Italian metosulam
Spanish metosulam
Greek -
Slovenian metosulam
Polish metosulam
Swedish -
Hungarian -
Dutch -

Record last updated: Thursday 13 September 2018
Contact: aeru@herts.ac.uk