Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!

molinate (Ref: OMS 1373)
** R 4572 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Molinate is a selective thiocarbamate herbicide that is not approved for use in the EU nor in the US. Molinate is highly soluble and persistent in water. It is also quite volatile. It would not normally be persistent in soil systems. It is moderately toxic to humans, is a cholinesterase inhibitor, may cause negative fertility/reproduction effects and is an irritant. It is moderately toxic to most fauna and flora.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for molinate

Description: A herbicide used to control germinating broad-leaved and grassy weeds in paddy fields and on some other crops

Example pests controlled: Broad-leaved weeds; Grasses

Example applications: Rice paddy fields; Beet crops

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1964, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Portugal
Date inclusion expires Expired
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C9H17NOS
Canonical SMILES CCSC(=O)N1CCCCCC1
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) DEDOPGXGGQYYMW-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H17NOS/c1-2-12-9(11)10-7-5-3-4-6-8-10/h2-8H2,1H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Thiocarbamate
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Selective, systemic absorbed by roots and translocated. Inhibition of lipid synthesis.
CAS RN 2212-67-1
EC number 218-661-0
CIPAC number 235
US EPA chemical code 041402
PubChem CID 16653
Molecular mass (g mol-1) 187.3
PIN (Preferred Identification Name) -
IUPAC name S-ethyl azepane-1-carbothioate
CAS name S-ethyl hexahydro-1H-azepine-1-carbothioate
Other status information Potential groundwater contaminant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) N
Herbicide Resistance Classification (WSSA) 8
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Echinochloa crus-galli
Echinochloa oryzicola
Physical state Clear liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Syngenta
  • NuFarm Australia
  • AgroSan
Example products using this active
  • Molinam
  • Agro-Dram
  • Molinlex
  • Molydyn
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Available as emulsifiable liquids and granules.


ENVIRONMENTAL FATE

for molinate

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 1100 A5 High
Solubility - In organic solvents at 20oC (mg l-1) Miscible A5 - Methanol -
Miscible A5 - Acetone -
Miscible A5 - Ethyl acetate -
Miscible A5 - Hexane -
Melting point (oC) -25 A5 - Freezing point -
Boiling point (oC) 278 A5 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 7.24 X 1002 Calculated -
Log P 2.86 A5 Moderate
Bulk density (g ml-1)/Specific gravity 1.063 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 500 A5 Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1) 6.87 X 10-01 A5 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.49 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.35 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 200nm, no absorption >290nm A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 28 A5 Non-persistent
DT50 (lab at 20oC) 28 A5 Non-persistent
DT50 (field) 12.5 A5 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) 62 A5 -
DT50 modelling endpoint - - -
Note Data for flooded conditions
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Estimated at 5-10% hydrolysis under field conditions
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 365 A5 Very persistent
Note Stable pH 5 to pH 7 at 25 and 50 degC
Water-sediment DT50 (days) 61 A5 Moderately fast
Water phase only DT50 (days) 4 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - A5 Moderately mobile
Koc 190
Notes and range EU dossier Koc range 121-206 mL/g
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
molinate sulfoxide Soil   0.066   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
carboxymolinate - - - -


ECOTOXICOLOGY

for molinate

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 72 F4 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 483 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 1 A5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 389 A5 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) 2500 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 16 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.39 A4 Oncorhynchus mykiss, 73 day Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 14.9 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.38 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 1.8 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 7.7 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.5 A5 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) > 11.0 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 289 A5 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 95 Mortality
Dose: 4.5 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 4.5 kg ha-1
A5 Typhlodromus pyri, adult female
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 10 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for molinate

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 483 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 4350 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 1.39 A5 Rat (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.008 A5, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.008 A5, SF=100 -
Dermal penetration studies (%) 2.2 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards Non-statutory WHO drinking water guideline 0.006 mg/L UK EA QS database, 2018 -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues May cause nausea, vomiting and diarrhea if ingested
May cause respiratory failure if inhaled
USEPA - some evidence to suggest possible human carcinogen
Endocrine issues - Reproductive tract damage, reduction of fertility

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H302, H317, H332, H351, H361f, H373
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Reproduction risk category 3: R63
Xn - Harmful: R20/22, R43, R48/22
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S46, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number Usually 2902
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for molinate

Language Name
English molinate
French molinate
German Molinat
Danish molinate
Italian molinate
Spanish molinato
Greek molinate
Slovenian molinat
Polish molinat
Swedish -
Hungarian molinat
Dutch molinaat

Record last updated: Wednesday 23 May 2018
Contact: aeru@herts.ac.uk