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novaluron (Ref: GR 572)
** MCW 275 ** SB 7242 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for novaluron

Description: A new insect growth regulator used to control a range of pests including Lepidoptera, Coleoptera, and Diptera

Example pests controlled: Whiteflies; Thrips; Leafhoppers; Armyworms; Leafminers

Example applications: Ornamentals; Glasshouse crops; Potatoes; Apples

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 2001, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Canada, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A molecule with one chiral feature. The technical material is a racemate.
Chemical formula C17H9ClF8N2O4
Canonical SMILES C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC(=C(C=C2)OC(C(OC(F)(F)F)F)(F)F)Cl)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) NJPPVKZQTLUDBO-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C17H9ClF8N2O4/c18-8-6-7(4-5-11(8)31-16(22,23)14(21)32-17(24,25)26)27-15(30)28-13(29)12-9(19)2-1-3-10(12)20/h1-6,14H,(H2,27,28,29,30)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide; Insect growth regulator
Substance group Benzoylurea
Minimum active substance purity 985 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action A chitin synthesis inhibitor, with stomach action and some contact activity
CAS RN 116714-46-6
EC number -
CIPAC number 672
US EPA chemical code 124002
PubChem CID 93541
Molecular mass (g mol-1) 492.70
PIN (Preferred Identification Name) -
IUPAC name (RS)-1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6-difluorobenzoyl)urea
CAS name N-(((3-chloro-4-(1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy)phenyl)amino)carbonyl)-2,6-difluorobenzamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 15
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Pale pink to white powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Makhteshim Agan
Example products using this active
  • Rimon 10EC
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as an emulsifiable concentrate that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for novaluron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.003 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 8.39 A5 - n-Heptane -
1880 A5 - Xylene -
2850 A5 - Dichloroethane -
113000 A5 - Ethyl acetate -
Melting point (oC) 177 A5 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.00 X 1004 Calculated -
Log P 4.3 L3 High
Bulk density (g ml-1)/Specific gravity 1.56 A5 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 1.60 X 10-02 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.00 A5 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.02 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.20 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 253nm = 15400; [Acidic solution: 253nm = 9780; [Basic solution: 263nm = 20500 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 72 L3 Moderately persistent
DT50 (lab at 20oC) 9.0 A5 Non-persistent
DT50 (field) 96.5 A5 Moderately persistent
DT90 (lab at 20oC) 120 A5 -
DT90 (field) 550 A3 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 5.0-13.0 days, field studies DT50 range 33-160 days, DT90 range 210->1000 days
Dissipation rate RL50 on plant matrix Value 14.7 R3 -
Note Peach fruit, n=1
Dissipation rate RL50 on and in plant matrix Value 3.5 R4 -
Note Published literature RL50 range 1.9-6.8 days, 3 field crops, various matrices, n=3
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note DT50 139 days natural light, 40 deg N
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note pH sensitive: stable pH 5 to pH 7, DT50 101 days at pH 9, 25 degC
Water-sediment DT50 (days) 17.5 A5 Fast
Water phase only DT50 (days) 0.95 A5 Fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 165 A5 Non-mobile
Koc 9598
Notes and range EU dossier Kd range 95-247 mL/g, Koc range 6650-11813 mL/g, Soils=4
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
chlorophenyl urea (Ref: 275-352-I) This metabolite may cause environmental pollution, click here for further information Soil   0.266   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2,6-difluorobenzoic acid
(Ref: 275-158-I)
difluorophenyl Soil (Anaerobic) 0.483 -


ECOTOXICOLOGY

for novaluron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 2091 A5 Threshold for concern
CT50 (days) 7.3 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 1176 A5 Rat Moderate
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 5200 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 1.0 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.00616 A5 Oncorhynchus mykiss High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.058 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.00003 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.00004 A5 Chironomus riparius High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.075 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 9.68 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 3.0 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 50 Mortality
Dose: 50 g ha-1
A5 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 54 Mortality
Dose: 50 g ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.4 mg kg-1, 28 days
-
Mesocosm study data NOEAEC mg l-1 0.00004 A5 Crangonyx pseudogracilis -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for novaluron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 5.15 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) Not allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.009 A3 proposed Rat, SF=100 -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders or local residents identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; A5 Calc MAC=30 μg l-1 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Spleen toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
CLP classification 2013 None allocated at this time
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S61, S60
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for novaluron

Language Name
English novaluron
French novaluron
German Novaluron
Danish novaluron
Italian novaluron
Spanish novaluron
Greek -
Slovenian novaluron
Polish nowaluron
Swedish -
Hungarian novaluron
Dutch -

Record last updated: Friday 24 August 2018
Contact: aeru@herts.ac.uk