Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides

phosalone (Ref: ENT 27163)
** benzofos ** benzphos ** NPH 1090 ** O,O-diethyl phosphorodithioate ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION
for phosalone

Description: An insecticide and acaricide used to control Coleoptera, Homoptera, Lepidoptera and other pests mainly on fruit

Introduction: circa 1965

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Austria
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status:
Pesticide type Insecticide, Acaricide
Substance group Organophosphate
Substance origin Synthetic
Mode of action Non-systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 2310-17-0
EC number 218-996-2
CIPAC number 109
US EPA chemical code 097701
Chiral molecule No
Chemical formula C12H15ClNO4PS2
SMILES Clc2ccc1c(OC(=O)N1CSP(=S)(OCC)OCC)c2
International Chemical Identifier key (InChIKey) IOUNQDKNJZEDEP-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3
Structure diagram/image available? Yes
Molecular mass (g mol-1) 367.8
PIN (Preferred Identification Name) -
IUPAC name S-6-chloro-2,3-dihydro-2-oxo-1,3-benzoxazol-3-ylmethyl O,O-diethyl phosphorodithioate
CAS name S-[(6-chloro-2-oxo-3(2H)-benzoxazolyl)methyl] O,O-diethyl phosphorodithioate
Other status information Severe Marine Pollutant
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Physical state Colourless crystals
Related substances & organisms -

Formulations:
Property Value
Example manufacturers & suppliers of products using this active -
Example products using this active
  • Zolone
UK LERAP status No UK approval for use or outside scope
Formulation and application details Supplied as an emulsifiable concentrate formulation.


ENVIRONMENTAL FATE

for phosalone

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 1.4 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 1000000 A5 - Acetone -
26300 A5 - n-Heptane -
1000000 A5 - Toluene -
1000000 A5 - Ethyl acetate -
Melting point (oC) 46.9 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 174.6 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.02 X 1004 Calculated -
Log P 4.01 A5 High
Bulk density (g ml-1)/Specific gravity 1.49 A5 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 25oC (mPa) 1.56 X 10-02 A5 Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1) 2.04 X 10-03 A5 Non-volatile
Henry's law constant at 20oC (dimensionless) 5.80 X 10-06 K3 Moderately volatile
GUS leaching potential index 0.21 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 5.55 X 10-04 Calculated -
Note -
Potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 203nm = 46918, 236nm = 14820, 284nm = 4602, 291nm = 3575 A5 -
Surface tension (mN m-1) 71.78 A5 -

Degradation:
Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 2 A5 Non-persistent
DT50 (lab at 20oC) 2 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 7.2 A5 -
DT90 (field) - - -
Note EU dossier lab studies DT50 range 0.8-4.9 days, DT90 range 2.8-16.3 days; Other sources: DT50 21 days (DW3)
Aqueous photolysis DT50 (days) at pH 7 Value 3.8 A5 Moderately fast
Note DT50 1.8 days in summer, 5.8 days in winter, artificial light, 40 deg N
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 321 A5 Persistent
Note pH sensitive: DT50 365 days at pH 4, 17.8 days at pH 9, all at 20 degC
Water-sediment DT50 (days) 4 A5 Fast
Water phase only DT50 (days) 2.8 A5 Moderately fast

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd 21.2 A5 Slightly mobile
Koc 2063
Notes and range EU dossier Koc range 870-2680 mL/g, degradation reported with clay
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity No

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
desethyl phosalone Phosalone metabolite M01 Rat - -
phenoxazone
(Ref: AE 0651017)
Note: Possible groundwater contaminant
RP18726 Water - -
2-amino-7-chloro-3H-phenoxazin-3-one
(Ref: AE 0651017)
- unknown - -
6-chloro-2(3H)-benzoxazolone
(Ref: AE F054014)
- Water (Hydrolysis @ pH9) - -
2-amino-5-chlorophenol
(Ref: AE F114970)
- Water (Anaerobic) - -
S-6-chloro-2,3-dihydro-2-oxo-benzoxazol-3-ylmethyl
(Ref: AE0941954)
- Water (Hydrolysis @ pH9) - -
deschlorophosalone
(Ref: RP 11690)
- Plant - -
6-chlorobenzoxazolone
(Ref: RP 11881)
- Plant - -
oxophosalone
(Ref: RP 12244)
- Plant - -
2-hydroxy-p-chloroaniline
(Ref: RP 18709)
- Rat - -
6-chloro-2,3-dihydro-3-methylsulfinylmethyl-1,3-benzoxazol-2-one
(Ref: RP 19889)
- Animal (Liver) - -
6-chloro-2,3-dihydro-3-methylthiomethyl-1,3-benzoxazol-2-one
(Ref: RP 19914)
- Animal (Liver) - -


ECOTOXICOLOGY

for phosalone

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF 180 A5 Whole fish Threshold for concern
CT50 (days) 0.71 -
Bioaccumulation potential - Calculated Moderate
Mammals - Acute oral LD50 (mg kg-1) 120 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 0.9 45 Rat, NOAEL High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 503 A4 Gallus gallus Moderate
Birds - Short term dietary (LC50/LD50) 1659 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 0.63 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.056 A5 Oncorhynchus mykiss -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.00074 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.00014 A5 Daphnia magna -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.019 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Algae - Acute 72 hour EC50, growth (mg l-1) 1.1 A5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.1 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) 4.4 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 22.5 A5 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.72 kg ha-1
A5 Aphidius rhopalosiphi, adult
Harmful
Other arthropod (2) LR50 g ha-1 45.8 7 day
A5 Typhlodromus pyri
Harmful at 1 kg ha-1
Moderately harmful at 0.1 kg ha-1
Harmless at 0.01 kg ha-1
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 12.7 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for phosalone

General:
Property Value Source/Quality Score/Other Information Interpretation
Mammals - Acute oral LD50 (mg kg-1) 120 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 1530 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 1.26 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A5 Rabbit, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.01 A2 Dog, SF=100 -
Dermal penetration studies (%) 0.7-3.6 A5 concentration dependant -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Dietary risk is considered low
Occupational Risk of exposure acceptable under label recommendations for use for personal protection clothing and equipment
Examples of European MRLs (mg kg-1) Value Apples and pears 2.0
Note A5 EU dossier proposals
For the EU pesticides database click here
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant Respiratory tract irritant Skin irritant Eye irritant

-

-

-

General human health issues Possible sensitiser

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General Prevent generation of dust
Not explosive
IMDG Transport Code is usually 6.1
CLP classification 2013 -
EC Risk Classification T - Toxic: R25
Xn - Harmful: R20/21, R43
N - Dangerous for the environment: R50, R53
EC Safety Classification S1/2, S36/37, S45, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number 2783
Waste disposal & packaging Packaging Group III (minor danger)


TRANSLATIONS

for phosalone

Language Name
English phosalone
French phosalone
German Phosalon
Danish phosalon
Italian fosalone
Spanish fosalon
Greek -
Slovenian fosalon
Polish fosalon
Swedish -
Hungarian phosalon
Dutch -

Record last updated: Monday 09 September 2013
Contact: aeru@herts.ac.uk