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prochloraz (Ref: BTS 40542)
** AE B080109 ** poraz ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for prochloraz

Description: A fungicide active against a wide range of diseases affecting cereals, field crops, fruit and many other crops

Example pests controlled: Anthracnose; Dothiorella complex; Stem-end rot; Eyespot

Example applications: Fruit; Field crops; Mushrooms; Turf; Avocados; Mangoes; Cereals including wheat, barley, winter rye, winter oilseed rape

Efficacy & activity: Wheat/Eyespot=Moderate; Wheat/Mildew=Low; Wheat/Septoria=Low; Wheat/Rust=Low; Barley/Net blotch=Low

Availability status: Current

Introduction & key dates: 1977, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Belgium/Denmark
Date inclusion expires 31/12/2021
EU Candidate for substitution (CfS) Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C15H16Cl3N3O2
Canonical SMILES CCCN(CCOC1=C(C=C(C=C1Cl)Cl)Cl)C(=O)N2C=CN=C2
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) TVLSRXXIMLFWEO-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C15H16Cl3N3O2/c1-2-4-20(15(22)21-5-3-19-10-21)6-7-23-14-12(17)8-11(16)9-13(14)18/h3,5,8-10H,2,4,6-7H2,1H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Imidazole
Minimum active substance purity >960 g/kg
Known relevant impurities EU dossier - Dioxans & furans <0.1 mg/kg
Substance origin Synthetic
Mode of action Broad-spectrum with protectant and eradicant properties. Disrupts membrane function.
CAS RN 67747-09-5
EC number 266-994-5
CIPAC number 407
US EPA chemical code 128851
PubChem CID 73665
Molecular mass (g mol-1) 376.7
PIN (Preferred Identification Name) -
IUPAC name N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide
CAS name N-propyl-N-(2-(2,4,6-trichlorophenoxy)ethyl)-1H-imidazole-1-carboxamide
Other status information -
Relevant Environmental Water Quality Standards UK non-statutory standard for the protection of aquatic life: freshwater and saltwater annual average: 4 ug/L; max acceptable conc: 40 ug/L
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 3
Examples of recorded resistance -
Physical state Colourless to white crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Bayer CropScience
  • BASF
  • Makhteshim-Agan
  • Nufarm
  • FBC
Example products using this active
  • Alpha Prochloraz
  • Mirage 40EC
  • Poraz
  • Grail
  • Omega
UK LERAP status None
Formulation and application details Often supplied as emulsifiable concentrates or wettable powder.


ENVIRONMENTAL FATE

for prochloraz

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 26.5 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 600000 A5 - Ethyl acetate -
600000 A5 - Acetone -
7500 A5 - Hexane -
600000 A5 - Methanol -
Melting point (oC) 48.3 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 220 A4 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 3.16 X 1003 Calculated -
Log P 3.5 A5 High
Bulk density (g ml-1)/Specific gravity 1.42 L3 -
Dissociation constant (pKa) at 25oC 3.8 A5 -
Note: Weak base
Vapour pressure at 20oC (mPa) 0.15 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.64 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.98 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 8.10 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral soluton: 300nm = 103; [Acidic solution: 300nm = 23; [Basic solution: 300nm = 58 A5 -
Surface tension (mN m-1) 53.07 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 120 W4 Persistent
DT50 (lab at 20oC) 223.6 A5 Persistent
DT50 (field) 16.7 A3 Non-persistent
DT90 (lab at 20oC) 865.0 A5 -
DT90 (field) 1124 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 22.1-936.1 days, DT90 range 90.8-2060 days; field study DT50 range 1.9-73.2 days, DT90 range 55-7545 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 5.6 R4 -
Note Published literature RL50 range 2.8-14.0 days, 4 field crops, various matrices, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 1.5 A5 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable at pH 5 and pH 7, DT50 78.9 days at pH 9, all at 22 degC
Water-sediment DT50 (days) 359 A5 Slow
Water phase only DT50 (days) 2.0 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - DW3 Slightly mobile
Koc 500
Notes and range -
Freundlich Kf 38.0 A5 Slightly mobile
Kfoc 1440
1/n 0.81
Notes and range EU dossier kf range 15.6-130 mL/g, Kfoc range 1222-8654 mL/g, 1/n range 0.76-0.86, Soils=10
pH sensitivity Less adsorption under alkaline conditions

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
N-formyl-N'-propyl-N'-2(2,4,6-trichlorophenoxy)ethylurea (Ref: BTS 44596) This metabolite may cause environmental pollution, click here for further information Soil   0.128   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
imidazole - Soil 0.026 -
(Ref: BTS 19036)
Note: Rat LD50 >800 mg kg-1
- Rat - -
(Ref: BTS 40348) - Soil 0.139 -
(Ref: BTS 44595)
Note: DT50 soil = 303 days
AEC 444595 Soil 0.063 -
(Ref: BTS 9608) - Rat (Urinary) - -
(Ref: M590F040) - Soil 0.077 -


ECOTOXICOLOGY

for prochloraz

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 371 A5 Threshold for concern
CT50 (days) 3.4 -
Mammals - Acute oral LD50 (mg kg-1) 1023 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 662 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) > 1580 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 1.5 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.049 A5 Pimephales promelas, 36 day Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 4.3 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.77 A5 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) >= 0.8 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.171 A5 Lemna gibba Moderate
Non-target plants > 1.0 A5 Oats in crop
Vegetative vigour, ER50
as L product/ ha (BAS 590 00F)
-
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 0.0055 A5 Scenedemus subspicatus High
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.01 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) 141.3 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 101 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 4.2 A5 Eisenia foetida corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect > 200 A5 Folsomia candida, 28 day NOEC mg kg-1 -
Other arthropod (1) LR50 g ha-1 85.1 48 hour
A5 Aphidius rhopalosiphi, adult
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 44.3 7 day
A5 Typhlodromus pyri, adult
-
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for prochloraz

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1023 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2100 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 2.16 A5 Rat, 4 hr (whole body) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.025 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.02 A5 Dog, SF=100 -
Dermal penetration studies (%) 1.2-3.2 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; Calc MAC=30 μg l-1; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Possible liver toxicant
USEPA - possible human carcinogen
Endocrine issues - Activation of Pregnane X cellular receptor

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H302
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Reproduction risk category 3: R63
Xn - Harmful: R22
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Variable with product, usually 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Contain/absorb spillage in suitable inert, absorbent material. Transfer to heavy duty plastic drums. Dispose in approved manner
Packaging Group III (minor danger)


TRANSLATIONS

for prochloraz

Language Name
English prochloraz
French prochloraz
German Prochloraz
Danish prochloraz
Italian procloraz
Spanish procloraz
Greek -
Slovenian prokloraz
Polish prochloraz
Swedish prokloraz
Hungarian prokloraz
Dutch -

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk