Propamocarb hydrochloride (Ref: SN 66752)

Propamocarb hydrochloride (Ref: SN 66752)	Last updated: 03/03/2021
(Also known as: propamocarb)

GENERAL INFORMATION

Description

A fungicide for specific control of Phycomycetes and effective against Phytophthora spp. and Pythium spp.

Example pests controlled

Late blight; Root rot; Damping off; Downy mildew (Bremia lactucae); Mildew

Example applications

Turf; Ornamentals; Tobacco; Vegetables; Potatoes; Strawberries; Cucumbers; Tomato; Lettuce

Efficacy & activity

Availability status

Current

Introduction & key dates

1978, first reported

UK regulatory status

UK COPR regulatory status

Approved

Date COPR inclusion expires

31/07/2024

UK LERAP status

Buffer probably required in UK - see product label

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Approved

Dossier rapporteur/co-rapporteur

Portugal/Belgium

Date EC 1107/2009 inclusion expires

31/07/2021

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece
✓	✓	✓	✓	✓	✓	✓	✓	✓
ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
✓	✓	✓	✓	✓	✓	✓	✓	✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia
✓	✓	✓	✓	✓	✓	✓	✓	✓

Also used in

Australia

Chemical structure

Isomerism

Chemical formula

C₉H₂₁ClN₂O₂

Canonical SMILES

CCCOC(=O)NCCCN(C)C.Cl

Isomeric SMILES

No data

International Chemical Identifier key (InChIKey)

MKIMSXGUTQTKJU-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C9H20N2O2.ClH/c1-4-8-13-9(12)10-6-5-7-11(2)3;/h4-8H2,1-3H3,(H,10,12);1H

2D structure diagram/image available?

Yes

General status

Pesticide type

Fungicide

Substance group

Carbamate

Minimum active substance purity

92-97%

Known relevant impurities

EU dossier - None declared

Substance origin

Synthetic

Mode of action

Systemic, with protective action absorbed by roots and leaves and translocated. Lipid synthesis inhibitor.

CAS RN

25606-41-1

EC number

247-125-9

CIPAC number

399.601

US EPA chemical code

119302

PubChem CID

15575641

Molecular mass

224.73

PIN (Preferred Identification Name)

IUPAC name

propyl 3-(dimethylamino)propylcarbamate hydrochloride

CAS name

propyl (3-(dimethylamino)propyl)carbamate monohydrochloride

Other status information

Relevant Environmental Water Quality Standards

Herbicide Resistance Classification (HRAC)

Not applicable

Herbicide Resistance Classification (WSSA)

Not applicable

Insecticide Resistance Classification (IRAC)

Not applicable

Fungicide Resistance Classification (FRAC)

Examples of recorded resistance

Physical state

Colourless crystals

Related substances & organisms

fenamidone

fluopicolide

mancozeb

propamocarb

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

Consento
Infinito
Merlin
Previcur N

Example products using this active

AgriGuard
Bayer CropScience
Fargro
Pan Agriculture

Formulation and application details

Often supplied as an aqueous solution

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

1005000

High

Solubility - In organic solvents at 20 °C (mg l⁻¹)

Toluene

4800

Dichloromethane

560000

Acetone

4800

Ethyl acetate

Melting point (°C)

64.2

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

150

Flashpoint (°C)

Not expected to self ignite; Not highly flammable

Octanol-water partition coefficient at pH 7, 20 °C

5.01 X 10^-02

Calculated

Log P

-1.3

Low

Bulk density (g ml⁻¹)

1.16

Dissociation constant pKa) at 25 °C

9.6

Weak acid

Vapour pressure at 20 °C (mPa)

8.70 X 10^-01

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

8.50 X 10^-09

Non-volatile

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Absorption observed at 203nm and 217nm at pH 7, no absorbance >290nm

Surface tension (mN m⁻¹)

71.98

at 20°C

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

39.3

Moderately persistent

DT₅₀ (lab at 20 °C)

22.3

Non-persistent

DT₅₀ (field)

Non-persistent

DT₉₀ (lab at 20 °C)

Moderately persistent

DT₉₀ (field)

DT₅₀ modelling endpoint

Note

EU dossier lab studies DT₅₀ range 8-149 days (normalised), DT₉₀ range 37-454; field studies DT₅₀ range 17.4-23.7 days

Dissipation rate RL₅₀ on plant matrix

Value

Note

Dissipation rate RL₅₀ on and in plant matrix

Value

7.7

Note

Published literature RL₅₀ range 1.3-22.7 days, 2 field crops, various matrices, n=4

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Stable

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Stable

Note

Stable at pH 4 to pH 9, at 25 and 50 °C

Water-sediment DT₅₀ (days)

Fast

Water phase only DT₅₀ (days)

Moderately fast

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d

K_oc

Notes and range

Freundlich

K_f

18.7

Slightly mobile

K_foc

706

¹/_n

0.87

Notes and range

EU dossier K_f range 1.29-77.20 mL g⁻¹, K_foc range 124-2451 mL g⁻¹, ¹/_n range 0.77-0.90, Soils=5

pH sensitivity

None, but adsorption may correlate to soil clay content

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

1.50

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

3.41 X 10^-02

Calculated

Note

Potential for particle bound transport index

Low

Calculated

Potential for loss via drain flow

Slightly mobile

Calculated

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

Metabolising enzymes

2-hydroxypropyl 3-(dimethylamino)propylcarbamate

Animal

propyl [3-(methylamino)propyl]carbamate

Animal

propyl-3-(dimethylamino)propylcarbamate-N-oxide

Animal

3-(3-dimethylaminopropyl)-4-hydroxy-4-methyloxazolidin-2-one

Animal

-
Note: Minor fraction

hydroxypropyl-propamocarb

Plant

-
Note: Minor fraction

propamocarb-N-oxyde

Plant

ECOTOXICOLOGY

Property

Value

Source; quality score; and other information

Interpretation

Bio-concentration factor

BCF (l kg⁻¹)

Low potential

CT₅₀ (days)

Not available

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 1330

Rat

Moderate

Mammals - Short term dietary NOEL

(mg kg⁻¹)

Rat

High

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

200

Rat Reproductive NOAEL

Moderate

Birds - Acute LD₅₀ (mg kg⁻¹)

> 1842

Anas platyrhynchos

Moderate

Birds - Short term dietary (LC₅₀/LD₅₀)

> 962 mg kg bw⁻¹ day⁻¹

Anas platyrhynchos

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

105

Colinus virginianus NOEC

Moderate

Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

> 99

Oncorhynchus mykiss

Moderate

Fish - Chronic 21 day NOEC (mg l⁻¹)

> 6.3

Lepomis macrochirus 32 day

Moderate

Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

> 100

Daphnia magna

Low

Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

12.3

Daphnia magna

Low

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)

> 18

Lemna gibba

Low

Non-target plants

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

> 85

Pseudokirchneriella subcapitata

Low

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

Unknown species

Low

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 84

Moderate

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other pollinators (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other pollinators (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

> 660

Eisenia foetida

Moderate

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

362

Eisenia foetida

Low

Other soil macro-organisms

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Other arthropod (1)

LR₅₀ g ha⁻¹

500

EC₅₀ (Other data: NOEL = 170 g ha⁻¹)
Aphidius rhopalosiphi adult

% Effect

Other arthropod (2)

LR₅₀ g ha⁻¹

360

EC₅₀ (Other data: LOEL = 360 g ha⁻¹)
Typhlodromus pyri adult

% Effect

Soil micro-organisms

Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect

Dose: 28/9 kg ha⁻¹

Mesocosm study data

NOEAEC mg l⁻¹

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 1330

Rat

Moderate

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 5.01

Rat

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.29

Rat SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

Rat SF=100

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.29

Rat SF=100

Dermal penetration studies (%)

Dangerous Substances Directive 76/464

Exposure Routes

Public

Occupational

MRLs

European

EU MRL pesticide database

Notes

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

No data found

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

No data found

General human health issues

Endocrine issues - Weak increase of aromatase activity and estrogen production

Handling issues

Property

Value and interpretation

General

Not explosive

CLP classification 2013

Health: H315, H317
Environment: H413

EC Risk Classification

Xn - Harmful: R43
N - Dangerous for the environment: R52

EC Safety Classification

S2, S24, S37, S46, S61

WHO Classification

U (Unlikely to present an acute hazard)

UN Number

Waste disposal & packaging

TRANSLATIONS

Language

Name

English

propamocarb hydrochloride

French

propamocarbe hydrochloride

German

Propamocarb

Danish

propamocarb

Italian

propamocarb

Spanish

propamocarb

Greek

Polish

chlorowodorek propamokarbu

Swedish

propamokarb hydroklorid

Hungarian

propamokarb-HCl

Dutch

propamocarb-hydrochloride

Record last updated:	03/03/2021
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242