Prosulfocarb (Ref: SC 0574)

Prosulfocarb (Ref: SC 0574)	Last updated: 12/01/2021
(Also known as: ICI A0574)

GENERAL INFORMATION

Description

A herbicide used for post-emergence control of grass and broad-leaved weeds in a wide range of crops

Example pests controlled

Annual meadow grass; Loose silky bent; Ryegrass; Chickweed; Cleavers; Dead-nettle; Speedwell; Nightshade; Field pansey

Example applications

Cereals including winter wheat and winter barley; Potatoes

Efficacy & activity

Availability status

Current

Introduction & key dates

1988, Belgium

UK regulatory status

UK COPR regulatory status

Approved

Date COPR inclusion expires

31/10/2024

UK LERAP status

Buffer probably required in UK - see product label

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Approved

Dossier rapporteur/co-rapporteur

Portugal/Sweden

Date EC 1107/2009 inclusion expires

31/10/2021

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece
✓	✓	✓	✓	✓	✓	✓	✓	✓
ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
✓	✓	✓	✓	✓	✓	✓	✓	✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia
✓		✓	✓	✓	✓	✓	✓	✓

Also used in

Australia

Chemical structure

Isomerism

Chemical formula

C₁₄H₂₁NOS

Canonical SMILES

CCCN(CCC)C(=O)SCC1=CC=CC=C1

Isomeric SMILES

No data

International Chemical Identifier key (InChIKey)

NQLVQOSNDJXLKG-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C14H21NOS/c1-3-10-15(11-4-2)14(16)17-12-13-8-6-5-7-9-13/h5-9H,3-4,10-12H2,1-2H3

2D structure diagram/image available?

Yes

General status

Pesticide type

Herbicide

Substance group

Thiocarbamate

Minimum active substance purity

970 g kg⁻¹

Known relevant impurities

EU dossier - None declared

Substance origin

Synthetic

Mode of action

Selective, absorbed by leaves and roots. Lipid synthesis inhibitor.

CAS RN

52888-80-9

EC number

401-730-6

CIPAC number

539

US EPA chemical code

PubChem CID

62020

Molecular mass

251.39

PIN (Preferred Identification Name)

IUPAC name

S-benzyl dipropyl(thiocarbamate)

CAS name

S-(phenylmethyl) dipropylcarbamothioate

Other status information

Relevant Environmental Water Quality Standards

Herbicide Resistance Classification (HRAC)

Herbicide Resistance Classification (WSSA)

Insecticide Resistance Classification (IRAC)

Not applicable

Fungicide Resistance Classification (FRAC)

Not applicable

Examples of recorded resistance

Physical state

Pale straw coloured liquid

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

Defy
Boxer
Dian

Example products using this active

AgChemAccess Ltd
Syngenta

Formulation and application details

Usually supplied as an emulsifiable concentrate that is mixed with water and applied as a spray

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

13.2

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

250000

Acetone

250000

Xylene

250000

n-Heptane

250000

Ethyl acetate

Melting point (°C)

-20

Boiling point (°C)

341

Degradation point (°C)

Flashpoint (°C)

Not expected to self ignite; Not highly flammable

Octanol-water partition coefficient at pH 7, 20 °C

3.02 X 10⁰⁴

Calculated

Log P

4.48

High

Bulk density (g ml⁻¹)

1.04

Dissociation constant pKa) at 25 °C

Not applicable

No disocciation

Vapour pressure at 20 °C (mPa)

0.79

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

0.0152

Non-volatile

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

>=295nm < 10, no absorbance maxima >210nm

Surface tension (mN m⁻¹)

60.9

at 20°C

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

11.9

Non-persistent

DT₅₀ (lab at 20 °C)

11.9

Non-persistent

DT₅₀ (field)

9.8

Non-persistent

DT₉₀ (lab at 20 °C)

Moderately persistent

DT₉₀ (field)

33.2

DT₅₀ modelling endpoint

Note

EU dossier lab studies DT₅₀ range 6.3-40.3 days (normalised), DT₉₀ range 21-128 days; field studies DT₅₀ range 6.5-13 days, DT₉₀ range 22-48 days

Dissipation rate RL₅₀ on plant matrix

Value

Note

Dissipation rate RL₅₀ on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Stable

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Stable

Note

Stable pH 5 to pH 9 at 25 and 40 °C

Water-sediment DT₅₀ (days)

214

Slow

Water phase only DT₅₀ (days)

0.94

Fast

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d

K_oc

Notes and range

Freundlich

K_f

23.1

Slightly mobile

K_foc

1693

¹/_n

0.96

Notes and range

EU dossier kf range 11.7-32.8, K_foc range 1367-2339 mL g⁻¹, ¹/_n range 0.896-1.023, Soils=3

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

0.76

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

1.07 X 10^-02

Calculated

Note

Potential for particle bound transport index

Medium

Calculated

Potential for loss via drain flow

Slightly mobile

Calculated

Key metabolites

Metabolite

Formation medium

Estimated maximum occurrence fraction

1107/2009 relevancy

prosulfocarb sulfoxide

Soil

0.072

Major fraction, Relevant

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

Metabolising enzymes

hippuric acid

Rat (Urinary)

benzylsulphonic acid

Rat (Urinary)

ECOTOXICOLOGY

Property

Value

Source; quality score; and other information

Interpretation

Bio-concentration factor

BCF (l kg⁻¹)

700

Whole fish

Threshold for concern

CT₅₀ (days)

1.7

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

1820

Rat

Moderate

Mammals - Short term dietary NOEL

(mg kg⁻¹)

Rat 2 year

(ppm diet)

> 200

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

> 50

Rat Reproductive NOAEL

Moderate

Birds - Acute LD₅₀ (mg kg⁻¹)

> 2250

Colinus virginianus

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

> 1506 mg kg bw⁻¹ day⁻¹

Anas platyrhynchos

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

131

Anas platyrhynchos NOEL

Moderate

Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

0.84

Oncorhynchus mykiss

Moderate

Fish - Chronic 21 day NOEC (mg l⁻¹)

0.31

Oncorhynchus mykiss

Moderate

Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

0.51

Daphnia magna

Moderate

Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

0.045

Daphnia magna

Moderate

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)

0.69

Lemna gibba

Moderate

Non-target plants

335

Tomato
Seedling emergence, ER₅₀
as g ha⁻¹

3140

Oat
Vegetative vigour, ER₅₀
as g ha⁻¹

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

0.049

Pseudokirchneriella subcapitata

Moderate

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 80

Apis mellifera

Moderate

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

103.4

Apis mellifera

Low

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other pollinators (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other pollinators (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

71.8

Eisenia foetida corr

Moderate

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

Other soil macro-organisms

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Other arthropod (1)

LR₅₀ g ha⁻¹

524

Typhlodromus pyri

% Effect

Other arthropod (2)

LR₅₀ g ha⁻¹

41.8

Aphidius rhopalosiphi

% Effect

Soil micro-organisms

Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect

Dose: 53.3 mg kg⁻¹ soil 42 days

Mesocosm study data

NOEAEC mg l⁻¹

0.015

Aquatic invertebrates and algae

NOEAEC mg l⁻¹

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

1820

Rat

Moderate

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 4.72

Rat

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.005

Rat SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

0.1

Rat SF=100

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.007

Rat SF=100

Dermal penetration studies (%)

0.2-3.2

concentration dependent

Dangerous Substances Directive 76/464

Exposure Routes

Public

No unacceptable risks to bystanders identified

Occupational

Some potenial risk to operators

European MRLs

EU MRL pesticide database

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

No data found

; ; ; ;

No data found

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

No data found

Respiratory tract irritant

Skin irritant

Skin sensitiser

Eye irritant

Phototoxicant

No data found

General human health issues

Moderately toxic

Handling issues

Property

Value and interpretation

General

Not explosive or oxidising
IMDG Transport Code is usually 9

CLP classification 2013

Health: H302, H317
Environment: H411

EC Risk Classification

Xn - Harmful: R22, R43
N - Dangerous for the environment: R51, R53

EC Safety Classification

S2, S24, S37, S61

WHO Classification

II (Moderately hazardous)

UN Number

3077

Waste disposal & packaging

Packaging Group III (minor danger)

TRANSLATIONS

Language

Name

English

prosulfocarb

French

prosulfocarbe

German

Prosulfocarb

Danish

prosulfocarb

Italian

prosulfocarb

Spanish

prosulfocarb

Greek

Polish

prosulfokarb

Swedish

prosulfokarb

Hungarian

Dutch

prosulfocarb

Record last updated:	12/01/2021
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242