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prosulfuron (Ref: CGA 152005)
** proszulfuron ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Prosulfuron is a broad-spectrurm herbicde approved for use at EU level. It is highly soluble in water and many organic solvents, is volatile, mobile and has a high potential for leaching to groundwater. It is generally moderately persistent in soil systems but can ve very persistent in aquatic systems. It is moderately toxic to mammals but is not expected to bioaccumulate. It is moderately toxic to birds, honeybees, earthworms and fish but less so to aquatic invertebrates. It is highly toxic to algae and aquatic plants.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for prosulfuron

Description: A herbicide used for broad-spectrum control of annual broad-leaved weeds

Example pests controlled: Buckwheat; Cocklebur; Lambsquarter; Wild mustard; Ragweed; Velvetleaf; Pigweed; Foxtail; Barnyard grass

Example applications: Sorghum; Millet; Winter wheat; Forage and grain maize; Soybean

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1994

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur France/Slovakia
Date inclusion expires 30/04/2024
EU Candidate for substitution (CfS) Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C15H16F3N5O4S
Canonical SMILES CC1=NC(=NC(=N1)OC)NC(=O)NS(=O)(=O)C2=CC=CC=C2CCC(F)(F)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) LTUNNEGNEKBSEH-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C15H16F3N5O4S/c1-9-19-12(22-14(20-9)27-2)21-13(24)23-28(25,26)11-6-4-3-5-10(11)7-8-15(16,17)18/h3-6H,7-8H2,1-2H3,(H2,19,20,21,22,23,24)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Sulfonylurea
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - 2-(3,3,3-trifluoro-propyl)-benzene sulfonamide <10 g/kg
Substance origin Synthetic
Mode of action Absorbed by leaves and roots. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS
CAS RN 94125-34-5
EC number -
CIPAC number 579
US EPA chemical code 129031
PubChem CID 91751
Molecular mass (g mol-1) 419.38
PIN (Preferred Identification Name) -
IUPAC name 1-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-3-[2-(3,3,3-trifluoropropyl)phenylsulfonyl]urea
CAS name N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]-2-(3,3,3-trifluoropropyl)benzenesulfonamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) B
Herbicide Resistance Classification (WSSA) 2
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Amaranthus rudis
Kochia scoparia
Physical state Colourless to pale beige crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Syngenta
Example products using this active
  • Jester
  • Peak 75WG
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details -


ENVIRONMENTAL FATE

for prosulfuron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 4000 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 160000 A5 - Acetone -
6100 A5 - Toluene -
56000 A5 - Ethyl acetate -
8400 A5 - Ethanol -
Melting point (oC) 155 A5 -
Boiling point (oC) Decomposes before boiling L3 -
Degradation point (oC) 155 L3 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 3.16 X 1001 Calculated -
Log P 1.5 A5 Low
Bulk density (g ml-1)/Specific gravity 1.45 A5 -
Dissociation constant (pKa) at 25oC 3.76 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 3.50 X 10-03 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.00 X 10-04 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 5.11 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 4.17 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 227.5nm = 21645, shoulder at 250nm, no absorption >290 nm A5 -
Surface tension (mN m-1) 63.0 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 62.1 A5 Moderately persistent
DT50 (lab at 20oC) 62.1 A5 Moderately persistent
DT50 (field) 11.9 A5 Non-persistent
DT90 (lab at 20oC) 404 A5 -
DT90 (field) 46.0 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 15.4-229 days, DT90 range 107-700 days, field studies DT50 range 3.8-38.9 days, DT90 range 15.2-129 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 242 A4 Stable
Note DT50: 178-337 days in dark at pH 9 and 25 degC, 257-198 days in sunlight
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note pH sensitive: DT50 5-12 days at pH 5, 424-651 days at pH 7, 682-1690 days at pH 9, all at 25 degC
Water-sediment DT50 (days) 173 A5 Slow
Water phase only DT50 (days) 103 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 0.34 A5 Very mobile
Kfoc 14.2
1/n 0.87
Notes and range EU dossier Kf range 0.03-1.45 mL/g, Kfoc range 3.9-237.3 mL/g, 1/n range 0.81-1.21, Soils=9
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-(3,3,3-trifluoropropyl)phenyl sulfonamide (Ref: CGA 159902) This metabolite may cause environmental pollution, click here for further information Soil   0.474   Major fraction, Relevancy unknown
2-amino-4-methoxy-6-methyl-1,3,5-triazine (Ref: IN-A4098) This metabolite may cause environmental pollution, click here for further information Soil   0.406   Major fraction, Relevancy unknown
O-desmethyl triasulfuron (Ref: CGA 300406) This metabolite may cause environmental pollution, click here for further information Soil   0.240   Major fraction, Relevancy unknown

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: CGA 150829) - Water; Sediment - -
demethoxy amino-prosulfosulfuron
(Ref: CGA 325025)
- Soil (Aerobic) 0.174 -
(Ref: CGA 325028) - Water; Sediment - -
(Ref: CGA 325030) - Water; Sediment - -
(Ref: CGA 349707) - a = Soil (Aerobic); b = Water; c = Sediment a=0.226 -


ECOTOXICOLOGY

for prosulfuron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 0.13 A5 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 546 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 3 A5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 1300 A5 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 100 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 5.8 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 120 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 148 A5 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.00126 A5 Lemna gibba High
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.0089 A4 Raphidocelis subcapitata, 72 hour High
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 0
99
Mortality
Fecundity
Dose: 0.04 kg product ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 20
120
Mortality
Fecundity
Dose: 0.015 kg product ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A4
Dose: Not stated, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for prosulfuron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 546 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.4 A5 Rat (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.02 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.06 A4 Dog, 90 day, SF=100 -
Dermal penetration studies (%) 0.1-4.0 A5 Concentration dependent -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Possible liver, heart & blood toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H302
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S60, S61
WHO Classification NL - Not listed
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for prosulfuron

Language Name
English prosulfuron
French prosulfuron
German Prosulfuron
Danish prosulfuron
Italian prosolfuron
Spanish prosulfuron
Greek -
Slovenian prosulfuron
Polish prosulfuron
Swedish -
Hungarian -
Dutch prosulfuron

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk