quinoclamine ** CAN ** ACNQ ** Translations

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GENERAL INFORMATION
for quinoclamine

Description: A selective herbicide and algicide used for post-emergence control of a range of weeds

Example pests controlled: Mosses; Liverworts; Duckweed; Algae

Example applications: Amenity turf; Rice

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1972

EC Regulation 1107/2009 (repealing 91/414):

Status	Approved
Dossier rapporteur/co-rapporteur	Sweden/Germany
Date inclusion expires	31/12/2018
EU Candidate for substitution (CfS)	No
Listed in EU database	Yes

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure:

Isomerism	-
Chemical formula	C10H6CINO2
Canonical SMILES	C1=CC=C2C(=C1)C(=O)C(=C(C2=O)Cl)N
Isomeric SMILES	No data
International Chemical Identifier key (InChIKey)	OBLNWSCLAYSJJR-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C10H6ClNO2/c11-7-8(12)10(14)6-4-2-1-3-5(6)9(7)13/h1-4H,12H2
2D structure diagram/image available?	Yes

General status:

Pesticide type	Herbicide, Algicide
Substance group	Unclassified
Minimum active substance purity	965 g/kg
Known relevant impurities	EU dossier - None declared
Substance origin	Synthetic
Mode of action	Selective, inhibits photosynthesis
CAS RN	2797-51-5
EC number	-
CIPAC number	648
US EPA chemical code	206501
PubChem CID	17748
Molecular mass (g mol-1)	207.61
PIN (Preferred Identification Name)	2-amino-3-chloronaphthalene-1,4-dione
IUPAC name	2-amino-3-chloro-1,4-naphthoquinone
CAS name	2-amino-3-chloro-1,4-naphthalenedione
Other status information	-
Relevant Environmental Water Quality Standards	-
Herbicide Resistance Classification (HRAC)	Not known
Herbicide Resistance Classification (WSSA)	-
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	Not applicable
Examples of recorded resistance	-
Physical state	Yellow crystals
Related substances & organisms	-

Formulations:

Property	Value
Example manufacturers & suppliers of products using this active now or historically	Certis Acros Organics
Example products using this active	Mogeton
UK LERAP status	No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details	Often supplied as a wettable powder that is mixed with water and applied as a spray.

ENVIRONMENTAL FATE
for quinoclamine

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		20.7	A5	Low
Solubility - In organic solvents at 20oC (mg l-1)		10000	A5 - Ethyl acetate	-
		10000	A5 - Methanol	-
		10000	A5 - p-Xylene	-
		10000	A5 - n-Heptane	-
Melting point (oC)		201	A5	-
Boiling point (oC)		348	A5	-
Degradation point (oC)		348	A4	-
Flashpoint (oC)		Not expected to self ignite; Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	3.80 X 1001	Calculated	-
	Log P	1.58	A5	Low
Bulk density (g ml-1)/Specific gravity		1.55	A5	-
Dissociation constant (pKa) at 25oC		Not applicable	A5	-
		Note: No dissociation
Vapour pressure at 20oC (mPa)		7.00 X 10-03	A5	Low volatility
Henry's law constant at 25oC (Pa m3 mol-1)		3.05 X 10-03	A5	Non-volatile
GUS leaching potential index		1.56	Calculated	Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	4.09 X 10-02	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Low
Maximum UV-vis absorption L mol-1 cm-1		219nm = 14100, 266nm = 21500, 339nm = 2410, 460nm = 2570	A5	-
Surface tension (mN m-1)		72.1	A5 at 20oC, 99%	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
General biodegradability		-
Soil degradation (days) (aerobic)	DT50 (typical)	22	A5	Non-persistent
	DT50 (lab at 20oC)	31	A5	Moderately persistent
	DT50 (field)	22	A5	Non-persistent
	DT90 (lab at 20oC)	103	A5	-
	DT90 (field)	67	A5	-
	DT50 modelling endpoint	-	-	-
	Note	Lab studies DT50 range 20-39 days, DT90 range 68-130 days; field studies DT50 range 11-29 days Germany, DT90 range 36-98 days
Dissipation rate RL50 on plant matrix	Value	-	-	-
	Note	-
Dissipation rate RL50 on and in plant matrix	Value	-	-	-
	Note	-
Aqueous photolysis DT50 (days) at pH 7	Value	2.2	A5	Moderately fast
	Note	Other data: DT50 60 days in distilled water, 31 days natural water (L3)
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	A5	-
	Note	Stable pH 5 to pH 9
Water-sediment DT50 (days)		15	A5	Fast
Water phase only DT50 (days)		4.6	A5	Moderately fast

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	9.1	-	Slightly mobile
	Koc	1161
	Notes and range	EU dossier Kd range 4.2-14 mL/g, Koc range 712-1609 mL/g, Soils=2
Freundlich	Kf	11.7	A5	Slightly mobile
	Kfoc	896
	1/n	0.77
	Notes and range	EU dossier Kf range 3.72-26, Kfoc range 552-1264 mL/g 1/n range 0.69-0.84, Soils=6
pH sensitivity		No

Other known metabolites:

Metabolite name and reference	Aliases	Formation medium / Rate	Estimated maximum occurrence fraction	Metabolising enzymes
2-amino-1,4-naphtoquinone	AN	Water/sediment	0.18 (whole system)	-
2-hydroxy-1,4-naphtoquinone	HN	Soil (Aerobic)	-	-
1,4-dihydroxynaphtoquinone	DHN	Soil (Aerobic)	-	-
-	HCN	Soil (Anaerobic)	-	-

ECOTOXICOLOGY
for quinoclamine

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF (l kg-1)	Low risk	A5 Based on LogP < 3	Low potential
	CT50 (days)	-		-
Mammals - Acute oral LD50 (mg kg-1)		> 200	A5 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	3	A5 Rat	High
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		> 2000	A4 Unknown species	Low
Birds - Short term dietary (LC50/LD50)		394 mg kg bw-1 day-1	A4 Unknown species	-
Fish - Acute 96 hour LC50 (mg l-1)		0.063	A5 Cyprinidae	High
Fish - Chronic 21 day NOEC (mg l-1)		0.02	A5 Oncorhynchus mykiss	Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		2.15	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.0021	A5 Daphnia magna	High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		0.063	A5 Chironomus riparius	Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		0.1	J2 Unknown species	Moderate
Non-target plants		870	A5 Brassica napus Vegetative vigour, ER50 as g/ha	-
		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		0.5	J2 Unknown species	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees	Contact acute 48 hour LD50 (μg bee-1)	> 0.75	A5	High
	Oral acute 48 hour LD50 (μg bee-1)	> 100	A5	Low
	Unknown mode acute 48 hour LD50 (μg bee-1)	-	-	-
Earthworms - Acute 14 day LC50 (mg kg-1)		> 125	A5 Eisenia foetida	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50 / EC50 / NOEC / % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	3810	>, 48 hour A5 Aphidius rhopalosiphi	-
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	3810	>, 7 day A5 Typhlodromus pyri	-
	% Effect	-	-	-
Soil micro-organisms		Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect	A5 Dose: 37.5 kg ha-1	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION
for quinoclamine

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		High (class III)	-	-
Mammals - Acute oral LD50 (mg kg-1)		> 200	A5 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 0.79	A5 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.002	A5	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.05	A5	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.03	A5 Dog, SF=100	-
Dermal penetration studies (%)		6.5-10.0	A5 concentration dependent	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	No unacceptable risks to bystanders identified
	Occupational	No unacceptable risks to operators or other workers identified
European MRLs		Click here for the EU MRL pesticide database
Drinking Water Standards		-	-	-
Drinking Water MAC (μg l-1)		0.1	EU Dir 89/778/EC limit; A5	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Cholinesterase inhibitor	Neurotoxicant
-	-	-			-
Respiratory tract irritant	Skin irritant	Skin sensitiser	Eye irritant	Phototoxicant
				-
General human health issues		No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		Not explosive IMDG Transport Code is usually 9 or 6.1
CLP classification 2013		Health: H317, H319, H335, H373, H361 Environment: H400, H410
EC Risk Classification		T - Toxic: R23, Xn - Harmful: R22, R43 Xi - Irritant: R36 N - Dangerous for the environment: R50, R53
EC Safety Classification		S20/21, S2, S13, S46, S61
WHO Classification		II	-	Moderately hazardous
US EPA Classification (formulation)		No consensus across products or no products available	-	-
UN Number		Usually 2811
Waste disposal & packaging		Packaging Group III (minor danger)

TRANSLATIONS
for quinoclamine

Language	Name
English	quinoclamine
French	quinoclamine
German	Quinoclamin
Danish	quinoclamin
Italian	quinoclamine
Spanish	quinoclamina
Greek	-
Slovenian	kvinoklamin
Polish	kwinoklamina
Swedish	kvinoklamin
Hungarian	-
Dutch	quinoclamine

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Record last updated: Friday 14 September 2018
Contact: aeru@herts.ac.uk