| sulfotep (Ref: ENT 16273) |
 |
Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for sulfotep
Description: An insecticide and acaracide fumigant used to control chewing and sucking insects. It is also an impurity of chlorpyrifos.
Example pests controlled: Aphids; Thrips; Spider mites; Whiteflies
Example applications: Greenhouses
Efficacy & activity: -
Availability status: Unknown
Introduction & key dates: 1945
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | Not applicable |
| Date inclusion expires | Expired |
| EU Candidate for substitution (CfS) | - |
| Listed in EU database | Yes |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Chemical structure:
| Isomerism | - |
| Chemical formula | C8H20O5P2S2 |
| Canonical SMILES | CCOP(=S)(OCC)OP(=S)(OCC)OCC |
| Isomeric SMILES | No data |
| International Chemical Identifier key (InChIKey) | XIUROWKZWPIAIB-UHFFFAOYSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C8H20O5P2S2/c1-5-9-14(16,10-6-2)13-15(17,11-7-3)12-8-4/h5-8H2,1-4H3 |
| Structure diagram/image available? | Yes |
General status:
| Pesticide type | Insecticide, Acaricide | |
| Substance group | Organophosphate | |
| Minimum active substance purity | - | |
| Known relevant impurities | - | |
| Substance origin | Synthetic | |
| Mode of action | Non-systemic with contact and respiratory action. Inhibitor of cholinesterase | |
| CAS RN | 3689-24-5 | |
| EC number | 222-995-2 | |
| CIPAC number | 198 | |
| US EPA chemical code | 079501 | |
| PubChem CID | 19395 | |
| Molecular mass (g mol-1) | 322.32 | |
| PIN (Preferred Identification Name) | O1,O1,O3,O3-tetraethyl 1,3-dithiodiphosphate | |
| IUPAC name | O,O,O',O'-tetraethyl dithiopyrophosphate | |
| CAS name | thiodiphosphoric acid (((HO)2P(S))2O) tetraethyl ester | |
| Other status information | Marine Pollutant | |
| Relevant Environmental Water Quality Standards | - | |
| Herbicide Resistance Classification (HRAC) | Not applicable | |
| Herbicide Resistance Classification (WSSA) | Not applicable | |
| Insecticide Resistance Classification (IRAC) | 1B | |
| Fungicide Resistance Classification (FRAC) | Not applicable | |
| Examples of recorded resistance | Myzus persicae Tetranychus urticae Trialeurodes vaporariorum |
|
| Physical state | Pale yellow liquid | |
| Related substances & organisms | ||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | No UK approval for use as a pesticide under EC Regulation 1107/2009 | |||
| Formulation and application details | Usually used as a fumigant. | |||
ENVIRONMENTAL FATE
for sulfotep
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 10 | L3 | Low | |
| Solubility - In organic solvents at 20oC (mg l-1) | Miscible | L2 - Acetone | - | |
| Miscible | L2 - Xylene | - | ||
| Miscible | L2 - Methanol | - | ||
| Melting point (oC) | Not applicable | L3 | - | |
| Boiling point (oC) | - | - | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | - | - | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 9.77 X 1003 | Calculated | - |
| Log P | 3.99 | L3 | High | |
| Bulk density (g ml-1)/Specific gravity | 1.2 | L3 | - | |
| Dissociation constant (pKa) at 25oC | - | - | - | |
| Note: | ||||
| Vapour pressure at 20oC (mPa) | 14 | L3 | Highly volatile | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 4.50 X 10-01 | L3 | Moderately volatile | |
GUS leaching potential index  |
1.64 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 4.43 X 10-02 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Low | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 28 | K4 | Non-persistent |
| DT50 (lab at 20oC) | - | - | - | |
| DT50 (field) | - | - | - | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | General literature DT50 range 14-42 days (R3) | |||
| Dissipation rate RL50 on plant matrix | Value | - | - | - |
| Note | - | |||
| Dissipation rate RL50 on and in plant matrix | Value | 1.5 | R4 | - |
| Note | Published literature RL50 range 1.0-2.0 days, leaves from 2 field grown crops, n=2 | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | Stable | L3 | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 8.2 | L3 | Non-persistent |
| Note | pH sensitive: DT50 10.7 days at pH 4, 9.1 days at pH 9, all at 22 degC | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | W3 | Slightly mobile |
| Koc | 740 | |||
| Notes and range | Literature values give Koc between 600 and 5000 mL/g | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
Other known metabolites:
| Metabolite name and reference | Aliases | Formation medium / Rate | Estimated maximum occurrence fraction | Metabolising enzymes |
| monosulfotep | - | Soil | - | - |
| tetraethyl pyrophosphate | - | Soil | - | - |
| O,O-diethyl phosphorothioate | - | Plant; Rat (Urinary) | - | - |
| diethyl phosphate | - | Plant | - | - |
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | - | - | - |
| CT50 (days) | - | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 5.0 | F4 Rat | High | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | L2 Rat, 2 year | - |
| (ppm diet) | 10 | - | ||
| Birds - Acute LD50 (mg kg-1) | > 25 | V2 Gallus gallus | High | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 0.00361 | L3 Oncorhynchus mykiss | High | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 0.002 | L3 Daphnia magna | High | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | > 7.2 | L3 Scenedemus subspicatus | Moderate | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | - | - | - |
| Oral acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | - | - | - | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for sulfotep
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 5.0 | F4 Rat | High | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | 65.0 | L3 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | 0.05 | L3 Rat (aerosol) | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.001 | L3 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | List I; List II | - | - | |
| Exposure Limits | [UK LT TWA 8 hr: 0.1 mg/m3] | UK EA QS database, 2018 | - | |
| Exposure Routes | Public | - | ||
| Occupational | - | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | No further information available | |||||||
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
No information available | |||
| CLP classification 2013 | Health: H310, H300 Environment: H400 |
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| EC Risk Classification |
T+ - Very toxic: R27/28 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S1/2, S23, S28, S36/37, S45, S60, S61 | |||
| WHO Classification | Ia | - | Extremely hazardous | |
| US EPA Classification (formulation) | I | - | Danger - Highly toxic | |
| UN Number | 1704 | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | sulfotep |
| French | sulfotep |
| German | Sulfotep |
| Danish | sulfotep |
| Italian | sulfotep |
| Spanish | sulfotep |
| Greek | sulfotep |
| Slovenian | sulfotep |
| Polish | sulfotep |
| Swedish | sulfotep |
| Hungarian | sulfotep |
| Dutch | sulfotep |
Record last updated: Friday 25 May 2018
Contact: aeru@herts.ac.uk