Thiodicarb (Ref: OMS 3026)

Thiodicarb (Ref: OMS 3026)	Last updated: 29/06/2019
(Also known as: Al3 29311; CGA 45156; RPA 80600M)

GENERAL INFORMATION

Description

A insecticide and molluscicide used to control Lepidoptera, Coleoptera, slugs and other pests fruit, vegetables and many other crops

Example pests controlled

Stem weevils; Black beetles; Springtails; Caterpillars; Cabbage white butterfly; Budworms; Tobacco loopers

Example applications

Cereals including wheat, triticale, rye, barley, oats; Grapes; Forage brassicas; Grass seed crops; Cotton; Maize; Sweetcorn; Pulses; Tomatoes; Tobacco

Efficacy & activity

Availability status

Current

Introduction & key dates

circa 1980

UK regulatory status

UK COPR regulatory status

Not approved

Date COPR inclusion expires

Expired

UK LERAP status

No UK approval for use

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Not approved

Dossier rapporteur/co-rapporteur

Date EC 1107/2009 inclusion expires

Expired

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece

ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg

LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia

Also used in

Australia

Chemical structure

Isomerism

Chemical formula

C₁₀H₁₈N₄O₄S₃

Canonical SMILES

CC(=NOC(=O)N(C)SN(C)C(=O)ON=C(C)SC)SC

Isomeric SMILES

No data

International Chemical Identifier key (InChIKey)

XDOTVMNBCQVZKG-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C10H18N4O4S3/c1-7(19-5)11-17-9(15)13(3)21-14(4)10(16)18-12-8(2)20-6/h1-6H3

2D structure diagram/image available?

Yes

Cambridge Crystallographic Data Centre diagrams

Common Name	Relationship	Link
thiodicarb	-

General status

Pesticide type

Insecticide, Molluscicide, Ovicide

Substance group

Carbamate

Minimum active substance purity

940 g kg⁻¹

Known relevant impurities

EU dossier - methomyl 5g kg⁻¹

Substance origin

Synthetic

Mode of action

Mainly stomach action but some contact effects. Cholinesterase inhibitor.

CAS RN

59669-26-0

EC number

261-848-7

CIPAC number

543

US EPA chemical code

114501

PubChem CID

6386307

Molecular mass

354.47

PIN (Preferred Identification Name)

IUPAC name

(3EZ,12EZ)-3,7,9,13-tetramethyl-5,11-dioxa-2,8,14-trithia-4,7,9,12-tetraazapentadeca-3,12-diene-6,10-dione

CAS name

dimethyl N,N'-(thiobis((methylimino)carbonyloxy))bis[ethanimidothioate]

Other status information

Chemical subject to PIC regulations

Relevant Environmental Water Quality Standards

Herbicide Resistance Classification (HRAC)

Not applicable

Herbicide Resistance Classification (WSSA)

Not applicable

Insecticide Resistance Classification (IRAC)

Fungicide Resistance Classification (FRAC)

Not applicable

Examples of recorded resistance

Helicoverpa armigera, Heliothis virescens, Pseudoplusia includens, Spodoptera exigua, Spodoptera litura, many others

Physical state

White powder

Related substances & organisms

propylene glycol

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

Judge
Toro

Example products using this active

Aventis
Bayer CropScience
Sipcam
Me2
Nufarm

Formulation and application details

Usually sulpplied as read-to-use bait or pellets but may be applied via aerosal dispersal

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

22.2

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

970

Ethanol

320

n-Hexane

920

Toluene

5330

Acetone

Melting point (°C)

172.6

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

184.7

Flashpoint (°C)

Not expected to self ignite; Not highly flammable

Octanol-water partition coefficient at pH 7, 20 °C

4.17 X 10⁰¹

Calculated

Log P

1.62

Low

Bulk density (g ml⁻¹)

1.47

Dissociation constant pKa) at 25 °C

Not applicable

No dissociation

Vapour pressure at 20 °C (mPa)

2.7

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

4.31 X 10^-02

Non-volatile

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Maxima at 232-234nm ~ 18000, >= 290nm = 10

Surface tension (mN m⁻¹)

71.97

at 20°C 94.1%

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

0.67

Non-persistent

DT₅₀ (lab at 20 °C)

0.39

Non-persistent

DT₅₀ (field)

Non-persistent

DT₉₀ (lab at 20 °C)

2.16

Non-persistent

DT₉₀ (field)

DT₅₀ modelling endpoint

Note

EU dossier lab studies DT₅₀ range 0.13-1.2 days, DT₉₀ range 0.42-3.9 days; field studies DT₅₀ range 17.6-18 days, 0.5-45 days

Dissipation rate RL₅₀ on plant matrix

Value

Note

Dissipation rate RL₅₀ on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Moderately fast

Note

Data for Autumn conditions, pH 6, 25 °C USA 35 deg N

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

30.8

Moderately persistent

Note

pH sensitive: DT₅₀ 69.1 days at pH 5, 0.26 days at pH 9, all at 25 °C

Water-sediment DT₅₀ (days)

0.05

Fast

Water phase only DT₅₀ (days)

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d

K_oc

Notes and range

Freundlich

K_f

1.05

Moderately mobile

K_foc

418

¹/_n

1.29

Notes and range

EU dossier K_foc range 55.2-1005.7 mL g⁻¹

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

1.73

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

4.39 X 10^-02

Calculated

Note

Potential for particle bound transport index

Low

Calculated

Potential for loss via drain flow

Moderately mobile

Calculated

Key metabolites

Metabolite

Formation medium

Estimated maximum occurrence fraction

1107/2009 relevancy

methomyl (Ref: OMS 1196)

Soil

0.800

Major fraction, Relevant

acetic acid

Soil

Not relevant

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

Metabolising enzymes

acetonitrile

Soil (Aerobic); Animal; Water

methomyl oxime
Note: DT50 soil = 7 days

Soil

0.25

methomyl methylol

Soil

S-methyl-N-[N-methyl-N- (methylaminothio) carbamoyloxy] thioacetamidate

Soil (a = Aerobic, b = Anaerobic)

a=0.40

ECOTOXICOLOGY

Property

Value

Source; quality score; and other information

Interpretation

Bio-concentration factor

BCF (l kg⁻¹)

6.3

Whole fish

Low potential

CT₅₀ (days)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

Rat

High

Mammals - Short term dietary NOEL

(mg kg⁻¹)

Rat

High

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

Birds - Acute LD₅₀ (mg kg⁻¹)

2023

Colinus virginianus

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

> 5620 mg kg feed⁻¹

Anas platyrhynchos

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

1.4

Lepomis macrochirus

Moderate

Fish - Chronic 21 day NOEC (mg l⁻¹)

Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

0.027

Daphnia magna

High

Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

0.0016

Daphnia magna

High

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

0.014

Americamysis bahia

High

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

0.08

Chironomus riparius

Moderate

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)

Non-target plants

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

8.3

Pseudokirchneriella subcapitata

Moderate

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

3.2

Unknown species

Low

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

3.1

Moderate

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

0.153

High

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other pollinators (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other pollinators (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

38.5

Eisenia foetida

Moderate

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

2.0

Eisenia foetida

Moderate

Other soil macro-organisms

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Other arthropod (1)

LR₅₀ g ha⁻¹

0.4

Mortality
Aphidius rhopalosiphi

% Effect

Mortality [Dose: 200 kg ha⁻¹]
Poecilus cupreus adult

Other arthropod (2)

LR₅₀ g ha⁻¹

377

>; Mortality
Typhlodromus pyri

% Effect

Parasitism [Dose: 200 kg ha⁻¹]
Aleochara bilineata adult

Soil micro-organisms

Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect

Dose: 10 mg kg⁻¹ soil

Mesocosm study data

NOEAEC mg l⁻¹

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

Rat

High

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

0.66

Rat

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.01

Rat SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

0.01

Rat SF=100

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.03

SF=100

Dermal penetration studies (%)

0.15-3.0

concentration dependent

Dangerous Substances Directive 76/464

Exposure Routes

Public

No unacceptable risks to bystanders identified

Occupational

No unacceptable risks to operators or other workers identified

European MRLs

EU MRL pesticide database

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

0.1

EU Dir 89/778/EC limit; Calc MAC=30.0 µg l⁻¹

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

No data found

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

No data found

Respiratory tract irritant

Skin irritant

Skin sensitiser

Eye irritant

Phototoxicant

No data found

General human health issues

USEPA - probable human carcinogen

Handling issues

Property

Value and interpretation

General

Not explosive
IMDG Transport Code is usually 6.1

CLP classification 2013

Health: H301, H330
Environment: H400

EC Risk Classification

T - Toxic: R23, R25
Xn - Harmful: R43
N - Dangerous for the environment: R50, R53

EC Safety Classification

S2, S61, S22, S36/37, S45, S60

WHO Classification

II (Moderately hazardous)

UN Number

2757

Waste disposal & packaging

Packaging Group III (minor danger)

TRANSLATIONS

Language

Name

English

thiodicarb

French

thiodicarbe

German

Thiodicarb

Danish

thiodicarb

Italian

tiodicarb

Spanish

tiodicarb

Greek

Polish

tiodikarb

Swedish

tiodikarb

Hungarian

Dutch

Record last updated:	29/06/2019
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242