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tolclofos-methyl (Ref: S 3349 )
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for tolclofos-methyl

Description: A fungicide seed treatment for soil-borne and seed-borne diseases

Example pests controlled: Seedling blight; Seed decay; Damping-off; Stem canker; Black scurf

Example applications: Potatoes; Lettuce; Soybean; Field corn; Sweetcorn; Popcorn; Cotton; Sorghum; Sugarbeet; Ornamentals

Efficacy & activity: Efficiacy established from field trials and long term use in the EU

Availability status: Current

Introduction & key dates: 1982, Japan

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Sweden/Denmark
Date inclusion expires 30/04/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C9H11Cl2O3PS
Canonical SMILES CC1=CC(=C(C(=C1)Cl)OP(=S)(OC)OC)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) OBZIQQJJIKNWNO-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H11Cl2O3PS/c1-6-4-7(10)9(8(11)5-6)14-15(16,12-2)13-3/h4-5H,1-3H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Chlorophenyl
Minimum active substance purity 960 g/kg
Known relevant impurities EU 2018 dossier - methanol 1 g/kg
Substance origin Synthetic
Mode of action Nonsystemic with contact action showing protective and curative properties. Lipid peroxidation inhibitor.
CAS RN 57018-04-9
EC number 260-515-3
CIPAC number 479
US EPA chemical code 128905
PubChem CID 91664
Molecular mass (g mol-1) 301.13
PIN (Preferred Identification Name) O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl phosphorothioate
IUPAC name O-2,6-dichloro-p-tolyl O,O-dimethyl phosphorothioate
CAS name O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl phosphorothioate
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 14
Examples of recorded resistance -
Physical state Colourless crystalline powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Certis
  • Scotts
  • FCC
  • King Tech Corp
  • Interfarm
  • Sumitomo
Example products using this active
  • Rizolex
  • Rizolex Flowable
  • Agrolex
  • Hektolex
  • Risolex
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Available in a variety of formulations including wettable powders, flowable concentrates and dry powders for seed treatment.


ENVIRONMENTAL FATE

for tolclofos-methyl

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.708 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 476000 A5 - Acetone -
343000 A5 - Xylene -
20000 A5 - n-Hexane -
38000 A5 - Methanol -
Melting point (oC) 79 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 120 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 6.31 X 1003 Calculated -
Log P 3.8 A5 High
Bulk density (g ml-1)/Specific gravity 1.52 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.877 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.70 X 10-01 A5 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.46 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.93 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 pH 7.2: 215.5nm = 2380, 275nm = 484, 282.5nm = 511 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Not readily biodegradable
Soil degradation (days) (aerobic) DT50 (typical) 7.6 A5 Non-persistent
DT50 (lab at 20oC) 7.6 A5 Non-persistent
DT50 (field) 30 H4 Moderately persistent
DT90 (lab at 20oC) 48.0 A5 -
DT90 (field) - - -
DT50 modelling endpoint 31.0 A5 worse case un-normalised lab study -
Note EU 2018 dossier lab studies DT50 range 2.1-16.4 days, DT90 range 6.8-102.9 days, Soils=12
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 6.7 R3 -
Note Published literature RL50 range 2.5-10.8 days, 2 field & undercover grown crops, various matrices, n=2
Aqueous photolysis DT50 (days) at pH 7 Value 38.3 A5 Stable
Note Data for November sunlight 40 deg N
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 97 A5 Moderately persistent
Note pH sensitive: DT50 126 days at pH 4, 102 days at pH 9, all at 20 degC
Water-sediment DT50 (days) 15 A5 Fast
Water phase only DT50 (days) 1.25 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 21.8 A5 Slightly mobile
Kfoc 3028
1/n 0.93
Notes and range EU 2018 dossier Kf range 7.60-320 mL/g, Kfoc range 1649-6139 mL/g, 1/n range 0.89-0.96, Soils=6
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
O-(2,6-dichloro-4-methylphenyl) O-methyl O-hydrogen phosphorothioate This metabolite may cause environmental pollution, click here for further information Soil   0.133   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
hydroxmethyl-tolclofos-methyl TM-CH2OH Plant - -
3,5-dichloro-4-hydroxybenzoic acid - Animal - -


ECOTOXICOLOGY

for tolclofos-methyl

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 670 A5 Threshold for concern
CT50 (days) 1.1 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 70.6 A5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 5000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 0.69 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.012 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 48 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.026 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.78 A5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.032 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 43.7 48 hour
A5 Aphidius rhopalosiphi, adult
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 25000 7 day
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 18.8 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for tolclofos-methyl

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 2.07 A5 Rat (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.064 A5 Mouse, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.14 A5 Mouse, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) 0.14 A5 Mouse, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.064 A5 Mouse, SF=100 -
Dermal penetration studies (%) 0.02-6.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Endocrine issues - Competitive binding to cellular estrogen receptors
Possible liver and kidney toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H317
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R43
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S24, S37, S60, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number Variable with product, usually 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for tolclofos-methyl

Language Name
English tolclofos-methyl
French tolclofos-methyle
German Tolclofos-methyl
Danish tolclofos-methyl
Italian tolclofos-metile
Spanish tolclofos-metil
Greek -
Slovenian tolklofos-metil
Polish tolchlofos metylowy
Swedish tolklofosmetyl
Hungarian -
Dutch tolclofos-methyl

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk