tricyclazole (Ref: EL 291) ** tizole ** tricyclazone ** Translations

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GENERAL INFORMATION
for tricyclazole

Description: A fungicide used mainly for prolonged control of rice blast

Example pests controlled: Rice blast

Example applications: Paddy rice

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1976, Philippenes

EC Regulation 1107/2009 (repealing 91/414):

Status	Not approved
Dossier rapporteur/co-rapporteur	Italy
Date inclusion expires	Not applicable
EU Candidate for substitution (CfS)	Not applicable
Listed in EU database	Yes

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Japan, Korea, China, India, Brazil, Colombia

Chemical structure:

Isomerism	-
Chemical formula	C9H7N3S
Canonical SMILES	CC1=C2C(=CC=C1)SC3=NN=CN23
Isomeric SMILES	No data
International Chemical Identifier key (InChIKey)	DQJCHOQLCLEDLL-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C9H7N3S/c1-6-3-2-4-7-8(6)12-5-10-11-9(12)13-7/h2-5H,1H3
Structure diagram/image available?	Yes

General status:

Pesticide type	Fungicide
Substance group	Triazolobenzothiazole
Minimum active substance purity	950 g/kg
Known relevant impurities	EU dossier - None declared
Substance origin	Synthetic
Mode of action	Systemic, absorbed by roots and foliage and translocated, used mainly as a protectant, inhibits melanin biosynthesis
CAS RN	41814-78-2
EC number	255-559-5
CIPAC number	547
US EPA chemical code	120201
PubChem CID	39040
Molecular mass (g mol-1)	189.24
PIN (Preferred Identification Name)	5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazole
IUPAC name	5-methyl-1,2,4-triazolo[3,4-b][1,3]benzothiazole
CAS name	5-methyl-1,2,4-triazolo(3,4-b)benzothiazole
Other status information	Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards	-
Herbicide Resistance Classification (HRAC)	Not applicable
Herbicide Resistance Classification (WSSA)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	16.1
Examples of recorded resistance	-
Physical state	Peach coloured granular solid
Related substances & organisms	imidacloprid fipronil thifluzamide

Formulations:

Property	Value
Example manufacturers & suppliers of products using this active now or historically	Dow AgroSciences
Example products using this active	Beam Beam Admire Bim Trooper
UK LERAP status	No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details	Available in a variety of formulations including wettable powders and water soluble bags.

ENVIRONMENTAL FATE
for tricyclazole

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		596	A5	High
Solubility - In organic solvents at 20oC (mg l-1)		13800	A5 - Acetone	-
		26500	A5 - Methanol	-
		4900	A5 - Xylene	-
		4900	A5 - Ethyl acetate	-
Melting point (oC)		185.9	A5	-
Boiling point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		285.3	A5	-
Flashpoint (oC)		Not expected to self ignite; Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	2.51 X 1001	Calculated	-
	Log P	1.4	A5	Low
Bulk density (g ml-1)/Specific gravity		1.4	L3	-
Dissociation constant (pKa) at 25oC		Not applicable	A5	-
		Note: No dissociation
Vapour pressure at 20oC (mPa)		0.027	L3	Low volatility
Henry's law constant at 25oC (Pa m3 mol-1)		5.86 X 10-07	A5	Non-volatile
GUS leaching potential index		5.34	Calculated	High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	8.68 X 10+00	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Medium
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		55.3	A5 at 20oC, 95.2%, 1.2 g l-1	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
General biodegradability		-
Soil degradation (days) (aerobic)	DT50 (typical)	450	M3	Very persistent
	DT50 (lab at 20oC)	795	A4	Very persistent
	DT50 (field)	130	E4	Persistent
	DT90 (lab at 20oC)	-	-	-
	DT90 (field)	-	-	-
	DT50 modelling endpoint	-	-	-
	Note	EU dossier 1 Lab study Italy; Manufacturers published data DT50 lab studies range 240-842 days, field studies DT50 47-213 days (E4) Other studies: 21 (DW3)
Dissipation rate RL50 on plant matrix	Value	-	-	-
	Note	-
Dissipation rate RL50 on and in plant matrix	Value	10.9	R4	-
	Note	Published literature RL50 range 7.7-14.0 days, field grown rice, various matrices, n=2
Aqueous photolysis DT50 (days) at pH 7	Value	Stable	A5	-
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	A5	-
	Note	Stable pH 3 to pH 9
Water-sediment DT50 (days)		453	A4	Stable
Water phase only DT50 (days)		92	A4	Stable

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	A5	Moderately mobile
	Koc	169
	Notes and range	koc range 156-177 mL/g
Freundlich	Kf	3.1	A5	Moderately mobile
	Kfoc	144
	1/n	0.75
	Notes and range	EU dossier kf range 2.21-3.9, Kfoc range 138-150 mL/g, 1/n range 0.737-0.778
pH sensitivity		No

Other known metabolites:

Metabolite name and reference	Aliases	Formation medium / Rate	Estimated maximum occurrence fraction	Metabolising enzymes
tricyclazole alcohol	-	Plant; Animal; Rat (Urinary, Faeces)	-	-

ECOTOXICOLOGY
for tricyclazole

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF (l kg-1)	3.1	Q2 Estimated	Low potential
	CT50 (days)	Not available		-
Mammals - Acute oral LD50 (mg kg-1)		289.7	A5 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	9.6	L2 Rat, 2 year	High
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		> 1528	A5 Anas platyrhynchos	Moderate
Birds - Short term dietary (LC50/LD50)		> 1528 mg kg bw-1 day-1	A5 Anas platyrhynchos	-
Fish - Acute 96 hour LC50 (mg l-1)		7.3	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.081	A4 Ictalurus punctutatus	Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		34	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.96	A5 Daphnia magna	Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		2.2	A5 Chironomus riparius	Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Non-target plants		-	-	-
		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		8.2	A5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees	Contact acute 48 hour LD50 (μg bee-1)	> 100	A5	Low
	Oral acute 48 hour LD50 (μg bee-1)	> 88.5	A5	Moderate
	Unknown mode acute 48 hour LD50 (μg bee-1)	-	-	-
Earthworms - Acute 14 day LC50 (mg kg-1)		> 1000	A5 Eisenia foetida	Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		250	A5 Eisenia foetida, 56 days	Low
Other soil macro-organisms - e.g. Collembola	LR50 / EC50 / NOEC / % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	460	> A5 Typhlodromus pyri	-
	% Effect	5.0	Mortality Dose: 0.45 kg ha-1 A5 Typhlodromus pyri	-
Other arthropod (2)	LR50 g ha-1	450	< A5 Aphidius rhopalosiphi	-
	% Effect	100	Mortality Dose: 0.45 kg ha-1 A5 Aphidius rhopalosiphi	-
Soil micro-organisms		Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect	A5 Dose: 3.8 mg kg-1 soil, 28 days	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION
for tricyclazole

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		High (class III)	-	-
Mammals - Acute oral LD50 (mg kg-1)		289.7	A5 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	E4 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 1.15	A5 Rat, 4 hr	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.03	L3	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		-	-	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	Negligible risk to bystanders considering intended uses
	Occupational	-
European MRLs		Click here for the EU MRL pesticide database
Drinking Water Standards		-	-	-
Drinking Water MAC (μg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Cholinesterase inhibitor	Neurotoxicant
	-	-			-
Respiratory tract irritant	Skin irritant	Skin sensitiser	Eye irritant	Phototoxicant
		-		-
General human health issues		Moderately toxic by inhalation and ingestion

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		Not explosive or oxidising IMDG Transport Code is usually 6.1
CLP classification 2013		Health: H302
EC Risk Classification		Xn - Harmful: R22
EC Safety Classification		S2
WHO Classification		II	-	Moderately hazardous
US EPA Classification (formulation)		II	-	Warning - Moderately toxic
UN Number		Usually 2588
Waste disposal & packaging		Packaging Group II (medium danger)

TRANSLATIONS
for tricyclazole

Language	Name
English	tricyclazole
French	tricyclazole
German	Tricyclazol
Danish	tricyclazol
Italian	triciclazolo
Spanish	triciclazol
Greek	-
Slovenian	triciklazol
Polish	tricyklazol
Swedish	-
Hungarian	-
Dutch	tricyclazole

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Record last updated: Wednesday 30 May 2018
Contact: aeru@herts.ac.uk