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warfarin
** coumafene ** coumaphene ** zoocoumarin ** warfarine ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for warfarin

Description: A rarely used anticoagulant rodenticide

Example pests controlled: Rats; Mice; Grey squirrels; Gophers

Example applications: Rats; Mice; Grey squirrels; Gophers

Efficacy & activity: -

Availability status: Current

Introduction & key dates: circa 1944

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Ireland
Date inclusion expires Expired
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule normally used as the racemate
Chemical formula C19H16O4
Canonical SMILES CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) PJVWKTKQMONHTI-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Rodenticide
Substance group Coumarin anticoagulant
Minimum active substance purity 990 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action 1st generation anticoagulant
CAS RN 81-81-2
EC number 201-377-6
CIPAC number 70
US EPA chemical code 086002
PubChem CID 54678486
CLP index number 607-056-00-0
Molecular mass (g mol-1) 308.33
PIN (Preferred Identification Name) rac-4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one
IUPAC name 4-hydroxy-3-[(1RS)-3-oxo-1-phenylbutyl]coumarin
CAS name 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
Other status information Marine Pollutant; Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Colourless to white crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Killgerm
Example products using this active
  • Sakarat X
  • Sewarin P
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Often supplied as ready-to-use baits, granules or bait concentrate.


ENVIRONMENTAL FATE

for warfarin

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 267 A5 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 54600 A5 - Acetone -
6.4 A4 - n-Heptane -
22200 A5 - Methanol -
16900 A5 - Ethyl acetate -
Melting point (oC) 165 A5 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 5.01 X 1000 Calculated -
Log P 0.7 A5 Low
Bulk density (g ml-1)/Specific gravity 1.35 A5 -
Dissociation constant (pKa) at 25oC 5.19 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 3.0 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.50 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.23 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.99 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: Maxima at 272, 282.5 & 306nm; [Basic solution: Maxima at 212.5, 293.5 and 311nm A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 5 K4 Non-persistent
DT50 (lab at 20oC) 5 K4 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note: -
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Not a significant degradation route
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 9
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 14.15 A4 Moderately mobile
Kfoc 174
1/n -
Notes and range EU dossier Kf range 0.66-46.77 mL/g, Kfoc range 18-390 mL/g
pH sensitivity Adsorption increases with decreasing soil pH

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
hydroxycoumarin - Soil (Aerobic) - -
hexahydrocoumarin - Soil (Aerobic) - -


ECOTOXICOLOGY

for warfarin

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 10.4 A5 Rat High
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) 4448 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 65.0 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 2.0 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 105 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 8.5 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 8.5 Q2 Unknown species Low
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) > 100 E3 Non-toxic when used as rodent bait Low
Earthworms - Acute 14 day LC50 (mg kg-1) > 10 E3 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for warfarin

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 10.4 A5 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 40 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 0.005 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) None allocated A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.0002 A5 Human therapeutic dose, SF=100 -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits [UK LT TWA 8 hr: 0.1 mg/m3], [UK ST 15 mins: 0.3 mg/m3] Occupation Exposure -
Exposure Routes Public Risk of exposure consider very low due to usage pattern
Occupational May be absorbed through the skin
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Highly toxic
Anticoagulant - causes internal hemorrhage
May be absorbed through the skin and cause systemic poisoning

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H360D, H372
Environment: H412
EC Risk Classification Click here to view information omn the EU risk phrases Reproduction risk category 2: R61
T - Toxic: R48/25
N - Dangerous for the environment: R52, R53
EC Safety Classification Click here to view information omn the EU safety phrases S45, S53, S61
WHO Classification Ib - Highly hazardous
US EPA Classification (formulation) I - Danger - Highly toxic
UN Number 3027
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group I (great danger)


TRANSLATIONS

for warfarin

Language Name
English warfarin
French warfarin
German Warfarin
Danish warfarin
Italian warfarin
Spanish warfarina
Greek -
Slovenian warfarin
Polish warfarin
Swedish warfarin
Hungarian -
Dutch warfarine

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk