bromuconazole (Ref: LS 860263) ** bromoconazole ** LS 850646 ** LS 850647 ** Translations

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GENERAL INFORMATION
for bromuconazole

Description: A foliar applied conazole fungicide for a range of crops including cereals

Example pests controlled: Rusts; Powdery mildew; Septoria tritici; Leaf spot; Eyespot

Example applications: Cereals including barley, wheat; Fruit; Vegetables; Grapevines; Turf; Ornamentals

Availability status: Current

Introduction & key dates: 1990, first reported; 1992, first marketed France

EC Regulation 1107/2009 (repealing 91/414):

Status	Approved
Dossier rapporteur/co-rapporteur	Belgium
Date inclusion expires	31/01/2021

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

General status:

Pesticide type	Fungicide
Substance group	Triazole (isomer mix)
Minimum active substance purity	960 g/kg
Known relevant impurities	EU dossier - None declared
Substance origin	Synthetic
Mode of action	Systemic. Sterol biosynthesis inhibitor.
CAS RN	116255-48-2
EC number	408-060-3
CIPAC number	680
US EPA chemical code	120503
Chiral molecule	Chiral, a specific isomer or a derivative of a chiral molecule
Chemical formula	C13H12BrCl2N3O
SMILES	BrC1CC(OC1)(c2c(Cl)cc(Cl)cc2)Cn3ncnc3
International Chemical Identifier key (InChIKey)	HJJVPARKXDDIQD-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C13H12BrCl2N3O/c14-9-4-13(20-5-9,6-19-8-17-7-18-19)11-2-1-10(15)3-12(11)16/h1-3,7-9H,4-6H2
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	377.06
PIN (Preferred Identification Name)	1-{[(2?,4?)-4-bromo-2-(2,4-dichlorophenyl)oxolan-2-yl]methyl}-1H-1,2,4-triazole
IUPAC name	1-[(2RS,4RS;2RS,4SR)-4-bromo-2-(2,4-dichlorophenyl)tetrahydrofurfuryl]-1H-1,2,4-triazole
CAS name	1-[[4-bromo-2-(2,4-dichlorophenyl)tetrahydro-2-furanyl]methyl]-1H-1,2,4-triazole
Other status information	-
Herbicide Resistance Classification (HRAC)	Not applicable
Herbicide Resistance Classification (WSSA)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	3
Examples of recorded resistance	-
Physical state	White to beige powder
Related substances & organisms	-

Formulations:

Property	Value
Example manufacturers & suppliers of products using this active now or historically	Bayer CropScience Interfarm
Example products using this active	Grannit 200SC Jazz
UK LERAP status	Buffer probably required in UK - see product label
Formulation and application details	Often available as suspension concentrate that is diluted with water and used as a spray.

ENVIRONMENTAL FATE
for bromuconazole

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		48.3	A5	Low
Solubility - In organic solvents at 20oC (mg l-1)		1790	A5 - n-Hexane	-
		187000	A5 - Toluene	-
		269.2	A5 - Acetone	-
		50000	A5 - n-Octanol	-
Melting point (oC)		84	A5	-
Boiling point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		194	A5	-
Flashpoint (oC)		Not expected to self ignite; Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	1.74 X 1003	Calculated	-
	Log P	3.24	A5	High
Bulk density (g ml-1)/Specific gravity		1.72	A5	-
Dissociation constant (pKa) at 25oC		2.75	A5	-
		Note: Strong acid, pKa (2) -4.02 Very strong acid
Vapour pressure at 25oC (mPa)		0.004	A5 - @ 25 degC	Low volatility
Henry's law constant at 25oC (Pa m3 mol-1)		1.31 X 10-05	A5	Non-volatile
Henry's law constant at 20oC (dimensionless)		1.28 X 10-08	Calculated	Non-volatile
GUS leaching potential index		3.02	Calculated	High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	3.50 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Medium
Maximum UV-vis absorption L mol-1 cm-1		Neutral solution: 202.5nm = 43936, 220nm = 10762; [Acidic solution: 202.5nm = 38527, 220nm = 11157; [Basic solution: 221.5nm = 9915	A5	-
Surface tension (mN m-1)		59.8	A5 at 21oC	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	190	B5	Persistent
	DT50 (lab at 20oC)	679	A5	Very persistent
	DT50 (field)	123	A3	Persistent
	DT90 (lab at 20oC)	2253	A5	-
	DT90 (field)	-	-	-
	Note	EU dossier lab studies DT50 range 329-1028 days, DT90 range 1091-3414 days; Various other studies lab range 119-1279 days, field studies DT50 range 5-214 days
Plant matrix DT50 (days)	Value	-	-	-
	Note	-
Aqueous photolysis DT50 (days) at pH 7	Value	Stable	A5	-
	Note	No photolytic degradation in pH range 5 to 9
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	30	A5	Moderately persistent
	Note	Not sensitive to pH
Water-sediment DT50 (days)		275	A5	Slow
Water phase only DT50 (days)		1.7	A5	Moderately fast

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	A5	Slightly mobile
	Koc	872
	Notes and range	EU dossier Koc range isomer LS850646 range 474-1086, LS850647 range 627-1539 mL/g, Soils=4
Freundlich	Kf	12.51	B5	Slightly mobile
	Kfoc	860
	1/n	0.82
	Notes and range	UK dossier Kf range 4.75-32.0 mL/g, Kfoc range 575-1333 mL/g, 1/n - no data, Soils=4
pH sensitivity		No

Other known metabolites:

Metabolite name and reference	Aliases	Formation medium / Rate	Estimated maximum occurrence fraction	Metabolising enzymes
(Ref: LS850920)	hydroxylated metabolite	Plant	-	-
1-[2-(2,4-dichlorophenyl)-2,5-dihydrofuran-2-ylmethyl]-1H-1,2,4-triazole (Ref: LS860364)	-	Rat; Plant; Soil; Fish	-	-
(Ref: LS860550)	3-hydroxy metabolite	Plant	-	-
(Ref: LS860551)	3-hydroxy metabolite	Plant	-	-
(Ref: LS870353)	2-ketone metabolite	Plant	-	-
2-(2,4-dichlorophenyl-2-(1,2,4-triazol-1-yl methyl)) tetrahydrofuran (Ref: LS871387)	-	Soil (Anaerobic, dark)	-	-
(Ref: RPA 401527)	5-H-2-ketone metabolite	Plant	-	-
(Ref: RPA 406117)	hydroxylated metabolite	Plant	-	-

ECOTOXICOLOGY
for bromuconazole

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF (l kg-1)	131	P4	Threshold for concern
	CT50 (days)	Not available		-
Mammals - Acute oral LD50 (mg kg-1)		328	A5 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	0.99	B4 Rat	High
	(ppm diet)	20		-
Birds - Acute LD50 (mg kg-1)		> 2150	A5 Colinus virginianus	Low
Birds - Short term dietary (LC50/LD50)		> 5000 mg kg feed-1	A5 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		1.7	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.21	A5 Oncorhynchus mykiss	Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		> 8.9	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.02	A5 Daphnia magna	Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		0.250	A5 Chironomus riparius	Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		3.125	A5 Chironomus riparius	Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		0.12	A5 Lemna gibba	Moderate
Non-target plants		-	-	-
		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		> 3.3	A5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees	Contact acute 48 hour LD50 (μg bee-1)	> 500	A5	Low
	Oral acute 48 hour LD50 (μg bee-1)	> 100	A5	Low
	Unknown mode acute 48 hour LD50 (μg bee-1)	-	-	-
Earthworms - Acute 14 day LC50 (mg kg-1)		> 500	A5 Eisenia foetida, corr	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		18.6	A5 Eisenia foetida, corr	Moderate
Other soil macro-organisms - e.g. Collembola	LR50 / EC50 / NOEC / % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	-19.2	Beneficial capacity Dose: 62.5 mL/ha A5 Aphidius rhopalosiphi, adults	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	-35.3	Beneficial capacity Dose: 62.5 mL/ha A5 Typhlodromus pyri, protonymph	-
Soil micro-organisms		Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect	A5 Dose: 0.667 mg kg-1, 28days	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION
for bromuconazole

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		High (class III)	-	-
Mammals - Acute oral LD50 (mg kg-1)		328	A5 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A4 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 5.0	A5 Rat, 4 hr (nose only)	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.01	A5 Rat, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.1	A5 Rat, SF=100	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.025	A5 Dog, SF=100	-
Dermal penetration studies (%)		5.0-45.0	A5 concentration dependant	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	Acceptable risks for proposed uses
	Occupational	Acceptable risks for proposed uses with PPE
European MRLs		Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Cholinesterase inhibitor	Neurotoxicant
	-	-
Respiratory tract irritant	Skin irritant	Skin sensitiser	Eye irritant	Phototoxicant
		-		-
General human health issues		Moderately toxic Possible liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		Not explosive or oxidising IMDG Transport Code is usually 9
CLP classification 2013		-
EC Risk Classification		Reproduction risk category 3: R63 Xn - Harmful: R22
EC Safety Classification		-
WHO Classification		II	-	Moderately hazardous
US EPA Classification (formulation)		No consensus across products or no products available	-	-
UN Number		Usually 3082
Waste disposal & packaging		Packaging Group III (minor danger)

TRANSLATIONS
for bromuconazole

Language	Name
English	bromuconazole
French	bromuconazole
German	Bromuconazol
Danish	bromuconazol
Italian	bromuconazolo
Spanish	bromuconazol
Greek	-
Slovenian	bromukonazol
Polish	bromukonazol
Swedish	-
Hungarian	bromukunazol
Dutch	-

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Record last updated: Monday 07 December 2015
Contact: aeru@herts.ac.uk