Crufomate
Last updated: 12/08/2021
(Also known as: amidofos; crufomatum; ruelene)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
An obsolete topical organophosphate insecticide that was used to control of grubs, lice, and horn fly on cattle
Considered obsolete but may be available in some countries
1959, first reported
Cattle
Crufomate is a chiral molecule with two steroisomers. The technical material is an isomeric mixture.
C₁₂H₁₉ClNO₃P
CC(C)(C)C1=CC(=C(C=C1)OP(=O)(NC)OC)Cl
No data
BOFHKBLZOYVHSI-UHFFFAOYSA-N
InChI=1S/C12H19ClNO3P/c1-12(2,3)9-6-7-11(10(13)8-9)17-18(15,14-4)16-5/h6-8H,1-5H3,(H,14,15)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
crufomate
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Insecticide
Organophosphate
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-
Synthetic
Acetyl cholinesterase inhibitor; Systemic, acts via the uncoupling of oxidative phosphorylation
[Cholinesterase, inhibitor]
299-86-5
206-083-1
122
012101
-
Not allocated
None
No
No data
291.71
-
(RS)-(4-tert-butyl-2-chlorophenyl methyl methylphosphoramidate)
2-chloro-4-(1,1-dimethylethyl)phenyl methyl methylphosphoramidate
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-
Colourless crystalline powder
Rulene
DowElanco
Obsolete
Not applicable
-
200
at 25 °C
Moderate
-
-
-
60
-
118
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-
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-
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2.63 X 1003
Calculated
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3.42
High
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106
at 25 °C
Highly volatile
2.53 X 10-04
Non-volatile
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-
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Soil adsorption and mobility
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Slightly mobile
1700
Estimated
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-
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-
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230
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
(Other literature Log BCF range -1.4 - 0.4 (R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
))
Threshold for concern
Not available
-
None
Terrestrial ecotoxicology
860
Rat
Moderate
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-
-
-
-
-
-
-
100
Wild bird
Moderate
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32
Oncorhynchus mykiss
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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860
Rat
Moderate
2000
Rabbit
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Subcutaneous LDLo = 50 mg kg⁻¹
Guinea pig
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0.1
JMPR 1968
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List I
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Possible risk as may be absorbed via inhalation, ingestion, skin and/or eye contact
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A3 A = Chromosome aberration (EFSA database) 3 = Negative
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Moderately toxic May cause respiratory problems
Combustable Prevent generation of dust IMDG Transport Code is 6.1 Not expected to autoignite
-
III (Slightly hazardous)
2783
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crufomate
crufomate
Crufomat
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crufomato
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-
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Record last updated:
12/08/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242