(Also known as: d-methoprene; ZR 2458; methoprene)
Data alerts
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Environmental fate Moderate alert: Drainflow: Slightly mobile; Potential for particle bound transport: Medium
Ecotoxicity High alert: Fish chronic ecotoxicity: High
Human health Low alert
Warning: Significant data are missing
GENERAL INFORMATION
Description
Topically applied to control fleas and ticks
Availability status
Current
Introduction & key dates
1975, USA
Examples of species treated
Dogs; cats
Chemical structure
Isomerism
S-methoprene is the trans-form of the chiral methoprene and is more biologically active that the cis-form.
A juvenile hormone mimic (terpene). Contact and stomach action, acts by mimicing the action of the juvenile hormone keeping the insect in an immature state
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
Dissociation constant pKa) at 25 °C
-
-
-
-
Vapour pressure at 20 °C (mPa)
3.15
B5 B = UK CRD and ACP evaluation documents / and other Defra (UK) documents (click here ) 5 = Verified data used for regulatory purposes
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
0.886
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Moderately volatile
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
-
-
-
Surface tension (mN m⁻¹)
-
-
-
Refractive Index
-
-
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
Soil degradation (days) (aerobic)
DT₅₀ (typical)
10
B3 B = UK CRD and ACP evaluation documents / and other Defra (UK) documents (click here ) 3 = Unverified data of known source
Non-persistent
DT₅₀ (lab at 20 °C)
-
-
-
DT₅₀ (field)
10
B3 B = UK CRD and ACP evaluation documents / and other Defra (UK) documents (click here ) 3 = Unverified data of known source
Non-persistent
DT₉₀ (lab at 20 °C)
-
-
-
DT₉₀ (field)
-
-
-
Note
-
Manure DT₅₀ (days)
-
-
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
1
B5 B = UK CRD and ACP evaluation documents / and other Defra (UK) documents (click here ) 5 = Verified data used for regulatory purposes
Moderately fast
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
Stable
B5 B = UK CRD and ACP evaluation documents / and other Defra (UK) documents (click here ) 5 = Verified data used for regulatory purposes
Stable
Note
-
Water-sediment DT₅₀ (days)
-
-
-
Water phase only DT₅₀ (days)
-
-
-
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
-
US3 US = US Dept of Agriculture National Resources Conservation Service - various datasheets, databases and online sources 3 = Unverified data of known source
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242