Eprinomectin |
![]() Last updated: 02/06/2023 |
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(Also known as: MK 397) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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Used for treatment and control of gastrointestinal roundworms, lungworms, warbles, sucking and biting lice, chorioptic and sarcoptic mange mites in beef and dairy cattle | |
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Cattle |
Chemical structure |
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Eprinomectin is a mixture of two isomeric molecules. | |
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C₅₀H₇₅NO₁₄+C₄₉H₇₃NO₁₄ | |
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CCC(C)C1C(C=CC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)NC(=O)C)OC)OC)C)C | |
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CC[C@H](C)[C@@H]1[C@H](C=C[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@@H]([C@@H](O7)C)NC(=O)C)OC)OC)\C)C | |
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ZKWQQXZUCOBISE-CRTGXIDZSA-N | |
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InChI=1S/C49H73NO14/c1-25(2)43-28(5)17-18-48(64-43)23-35-20-34(63-48)16-15-27(4)44(26(3)13-12-14-33-24-57-46-42(52)29(6)19-36(47(53)60-35)49(33,46)54)61-40-22-38(56-11)45(31(8)59-40)62-39-21-37(55-10)41(30(7)58-39)50-32(9)51/h12-15,17-19,25-26,28,30-31,34-46,52,54H,16,20-24H2,1-11H3,(H,50,51)/b13-12-,27-15-,33-14-/t26-,28-,30-,31-,34+,35-,36-,37+,38-,39-,40-,41+,42+,43+,44-,45+,46+,48+,49+/m0/s1 | |
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Yes |
General status |
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Insecticide, Acaricide, Antiparasitic, Nematicide, Anthelminthic, Endectocide | |
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Avermectin | |
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Semi-synthetic | |
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Contact and stomach action with limited systemic activity, blocks electrical activity in nerves and muscles of pest. Glutamate-gated chloride channel (GluCl) allosteric modulator. | |
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123997-26-2 | |
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QP54AA04 | |
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Antiparasitic products, insecticides & repellents: Endectocides | |
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No | |
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Allowed substance (Table 1: Bovine) | |
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900.11 | |
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mix of (10E,14E,16E)-(1R,4S,5'S,6S,6'R,8R,12S,13S,20R,21R,24S)-6'-[(S)-sec-butyl]-21,24-dihydroxy-5',11,13,22-tetramethyl-2-oxo-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2'-(5',6'-dihydro-2'H-pyran)-12-yl 4-O-(4-acetamido-2,4,6-trideoxy-3-O-methyl-a-L-lyxo-hexopyranosyl)-2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranoside (major component) and (10E,14E,16E)-(1R,4S,5'S,6S,6'R,8R,12S,13S,20R,21R,24S)-21,24-dihydroxy-6'-isopropyl-5',11,13,22-tetramethyl-2-oxo-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2'-(5',6'-dihydro-2'H-pyran)-12-yl 4-O-(4-acetamido-2,4,6-trideoxy-3-O-methyl-a-L-lyxo-hexopyranosyl)-2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranoside (minor component) | |
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(4'R)-4'-(acetylamino)-4'-deoxyavermectin B1 | |
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White or pale yellow crystalline powder |
Formulations |
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Eprinex Pour On for Beef & Dairy cattle | Merial Animal Health | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
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Available in a variety of formulations including pour-ons |
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164 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Degradation |
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64 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Moderately persistent | |||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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24a-hydroxymethyl eprinomectin | - | Rat (Faeces) | - | - | |||||
24a-hydoxy eprinomectin | - | Rat (Faeces) | - | - |
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Terrestrial ecotoxicology |
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35 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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272 | R4 R = Peer reviewed scientific publications Colinus virginianus4 = Verified data |
Moderate | ||||||||
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56 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderate | ||||||||
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Aquatic ecotoxicology |
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1.2 | R4 R = Peer reviewed scientific publications Oncorhynchus mykiss4 = Verified data |
Moderate | ||||||||
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0.37 | R4 R = Peer reviewed scientific publications Oncorhynchus mykiss 96 hr4 = Verified data |
Moderate | ||||||||
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0.00045 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
High | ||||||||
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7 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum 14 day4 = Verified data |
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General |
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High (class III) | - | - | ||||||||
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35 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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0.005 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Dog SF=2005 = Verified data used for regulatory purposes |
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In cattle eprinomectin is mainly excreted in bile and feces, only a small proportion is excreted in urine or is present in milk. | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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Health issues |
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Possible liver and kidney toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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eprinomectin | ||
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eprinomectine | ||
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Eprinomectine | ||
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eprinomectina | ||
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Record last updated: | 02/06/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |