Streptomycin |
![]() Last updated: 17/11/2022 |
![]() |
(Also known as: streptomycine; streptamine; streptomycin A ; Crop antibiotic) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
---|---|---|
![]() Significant data are missing |
|
![]() |
|
Used as a bactericidal antibiotic | |
---|---|---|
|
- | |
|
1944, first reported; 1958, commericalised USA | |
|
Cattle, Sheep, Horses, Cats, Dogs |
Chemical structure |
|
A chiral molecule | |
---|---|---|
|
C₂₁H₃₉N₇O₁₂ | |
|
CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O | |
|
C[C@@H]1[C@]([C@@H]([C@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC)(C=O)O | |
|
UCSJYZPVAKXKNQ-APUVXCOVSA-N | |
|
InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+/m1/s1 | |
|
Yes |
General status |
|
Antibiotic, Antibacterial, Medicinal drug | |
---|---|---|
|
Micro-organism | |
|
- | |
|
- | |
|
Natural | |
|
A aminoglycoside that inhibites protein biosynthesis, systemic action | |
|
[30S ribosomal protein S12, antagonist], [16S rRNA, antagonist] | |
|
57-92-1 | |
|
200-355-3 | |
|
312 | |
|
006306 | |
|
19649 | |
|
QJ01GA01 | |
|
Antiinfectants for systemic use: Antibacterials for systemic use | |
|
No | |
|
Allowed substance (Table 1: Ruminants, Porcine, Rabbits) | |
|
581.57 | |
|
- | |
|
O-2-deoxy-2-methylamino-α-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1-4)-N1,N3-diamidino-D-streptamine | |
|
O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-D-streptamine | |
|
- | |
|
- | |
|
White powder | |
|
Formulations |
|
|
|
|
|
||||||
---|---|---|---|---|---|---|---|---|---|---|
|
Devomycin 250mg/ml Solution for Injection. | Norbrook Labs | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Devomycin Dl Solution for Injection. | Norbrook Labs | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Multiject IMM Intramammary Suspension | Norbrook Labs | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Orojet Lamb Oral Solution | Pfizer Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
|
It is available as a water soluble powder, pellets or as an emulsifiable concentrate. Applied as a foliar spray for crop protetcion. |
|
![]() |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
1000000 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) at 25 °C3 = Unverified data of known source |
High | ||||||||
|
- | - | - | ||||||||
|
12 | Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
3.16 X 10-08 | Calculated | - | |||||||
|
-7.5 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) 3 = Unverified data of known source |
Low | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
n/a | - | - | ||||||||
- | |||||||||||
|
7.76 X 10-23 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) at 25 °C3 = Unverified data of known source |
Low volatility | ||||||||
|
8.52 X 10-39 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) at 25 °C3 = Unverified data of known source |
Non-volatile | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - |
Degradation |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | - | - | |||||||
|
1.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-persistent | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
No risks identified | ||||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - |
Soil adsorption and mobility |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | ||||||||||
|
|
- | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Moderately mobile | |||||||
|
339 | ||||||||||
|
- | ||||||||||
|
- | ||||||||||
|
- |
Fate indices |
|
|
|
|
||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.00 | Calculated | Low leachability | ||||||||||||||||||||||||||
|
|
Low risk | Q3 Q = Miscellaneous internet resources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
|
- | - |
Known metabolites |
None
|
![]() |
Terrestrial ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
> 9000 | G3 G = Extension Toxicology network database EXTOXNET (click here ) Rat3 = Unverified data of known source |
Low | ||||||||
|
|
- | - | - | |||||||
|
- | - | |||||||||
|
- | - | - | ||||||||
|
> 4640 | E4 E = Manufacturers safety data sheets Anas platyrhynchos4 = Verified data |
Low | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | - | - | |||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
- | |||||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - |
Aquatic ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
> 180 | E4 E = Manufacturers safety data sheets Oncorhynchus mykiss4 = Verified data |
Low | ||||||||
|
- | - | - | ||||||||
|
487 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Low | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
0.133 | R4 R = Peer reviewed scientific publications Pseudokirchneriella subcapitata4 = Verified data |
Moderate | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - |
|
- | - | - |
|
![]() |
General |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
High (class III) | - | - | ||||||||
|
> 9000 | G3 G = Extension Toxicology network database EXTOXNET (click here ) Rat3 = Unverified data of known source |
Low | ||||||||
|
325 | L3 L = Pesticide manuals and hard copy reference books / other sources Mouse3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
|
Intraperitoneal LD₅₀ = 525 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Mouse3 = Unverified data of known source |
- | ||||||||
Intravenous LDLo = 175 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rat3 = Unverified data of known source |
- | |||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | |||||||||
|
- | ||||||||||
|
Majority of oral dose is excreted in the faeces. Parenteral administration leads to urinal elimination. | R4 R = Peer reviewed scientific publications 4 = Verified data |
- |
Health issues |
|
|
||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
May cause rashes, hives, headache, drop in blood pressure, nausea and vomiting Possible kidney toxicant May cause hearing dysfunction |
Handling issues |
|
|
|||
---|---|---|---|---|
|
No information available | |||
|
- | |||
|
NL (Not listed) | |||
|
- | |||
|
- |
|
![]() |
|
|
||
---|---|---|---|
|
streptomycin | ||
|
streptomycine | ||
|
Streptomyzin | ||
|
- | ||
|
streptomicina | ||
|
estreptomicina | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- |
Record last updated: | 17/11/2022 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |