Nitenpyram (Ref: CGA 246916)
Last updated: 23/08/2023
(Also known as: (E)-nitenpyram ; TI 204; niterndipoine)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
An insecticide used mainly to kill external parasites in livestock and domestic pets
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1989 discovered, 1995 launched
Cats, Dogs
Isomeric - molecule has one E/Z centre
C₁₁H₁₅ClN₄O₂
CCN(CC1=CN=C(C=C1)Cl)C(=C[N+](=O)[O-])NC
CCN(CC1=CN=C(C=C1)Cl)/C(=C/[N+](=O)[O-])/NC
CFRPSFYHXJZSBI-DHZHZOJOSA-N
InChI=1S/C11H15ClN4O2/c1-3-15(11(13-2)8-16(17)18)7-9-4-5-10(12)14-6-9/h4-6,8,13H,3,7H2,1-2H3/b11-8+
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
nitenpyram
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Insecticide, Anti-parasitic
Neonicotinoid insecticide
>98%
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Semi-natural
Systemic with translaminar activity, stomach and contact action affecting insects nervous system. No long term activity.Nicotinic acetylcholine receptor (nAChR) competitive modulator.
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150824-47-8
634-900-5
None allocated
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3034287
No data found
QP53BX02
Antiparasitic products, insecticides & repellents: Ecoparasiticides, insecticides & repellents
No
No data
270.72
(1E)-N-[(6-chloropyridin-3-yl)methyl]-N-ethyl-N'-methyl-2-nitroethene-1,1-diamine
(E)-N-(6-chloro-3-pyridylmethyl)-N-ethyl-N'-methyl-2-nitrovinylidenediamine
(1E)-N-[(6-chloro-3-pyridinyl)methyl]-N-ethyl-N'-methyl-2-nitro-1,1-ethenediamine
PAN listed Highly Hazardous Chemical
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Pale yellow to orange crystalline solid
Bob Martin Flea Tablets
Novartis Animal Health
UK National authorisation (IC)
Authorised veterinary medicine for general sale (AVM - GSL)
Capstar 11.4mg Tablets for Cats and Small Dogs
Novartis Animal Health
EU Mutually recognised procedure
Authorised veterinary medicine for general sale (AVM - GSL)
Johnsons 4Fleas 57mg Tables for Dogs
Novartis Animal Health
UK National authorisation (IC)
Authorised veterinary medicine for general sale (AVM - GSL)
Johnson's One Dose Easy Wormer for Dogs and Puppies, 500 mg Film Coated Tablets
Novartis Animal Health UK Ltd
UK National authorisation (IC)
Authorised veterinary medicine for general sale (AVM - GSL)
Usually supplied as a dusting powder, granules, drops and impregnated collars for topical use and as tablets for oral treatments.
570000
E4 E = Manufacturers safety data sheets 4 = Verified data
High
1000000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Methanol
-
700000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Chloroform
-
290000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Acetone
-
4500
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Xylene
-
72
E4 E = Manufacturers safety data sheets 4 = Verified data
-
417.2
E4 E = Manufacturers safety data sheets 4 = Verified data
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-
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-
-
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2.19 X 10-01
Calculated
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-0.66
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
at 25 °C
Low
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-
-
-
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1.254
E4 E = Manufacturers safety data sheets 4 = Verified data
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3.1
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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-
0.0011
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Low volatility
3.54 X 10-13
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Non-volatile
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-
-
-
-
-
-
-
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8
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Non-persistent
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General literature states DT₅₀ 1-15 days
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Stable
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Stable
Stable pH 3-7 at 25 °C; pH9 DT₅₀ = 2.9 days
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Soil adsorption and mobility
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Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source
Mobile
60
Estimated
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2.01
Calculated
Transition state
Low risk
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Based on LogP < 3
Low risk
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-
Known soil and groundwater metabolites
None
2-(N-(6-chloro-3-pyridylmethyl)-N-ethyl-N-methylformamidine
3-CPMF
Plant
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-
2-(N-(6-chloro-3-pyridylmethyl)-N-ethyl)amino-2-methyliminoacetic acid
2-CPMA
Plant
-
-
Terrestrial ecotoxicology
1575
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
Moderate
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-
-
-
-
-
-
-
1124
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Anas platyrhynchos
Moderate
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-
-
-
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-
32.2
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Moderate
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-
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0.138
R4 R = Peer reviewed scientific publications 4 = Verified data
High
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10
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Oncorhynchus mykiss
Moderate
-
-
-
10000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Daphnia magna
Low
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
26
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Pseudokirchneriella subcapitata
Low
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-
-
-
-
-
-
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-
HUMAN HEALTH AND PROTECTION
High (class III)
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-
1575
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
Moderate
2000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
-
5.8
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
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In mammals it is excreted mostly unchanged in the urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
XNo, known not to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
No further information available
Corrosive
Health: H302, H315, H319, H335 Environment: H400, H410
II (Moderately hazardous)
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Limited shelf-life. Store at -20 DegC
nitenpyram
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Record last updated:
23/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242