Chlortetracycline
Last updated: 29/03/2022
(Also known as: aureomycin ; biomycin )
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
Broad spectrum antibiotic and antimicrobial substance isolated from the microorganism (treptomyces aureofaciens) used in veterinary products and for aquaculture
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1945, first discovered
Agricultural livestock including: Poultry, Pigs and Fish
Isomeric
C₂₂H₂₃ClN₂O₈
CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O
C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O
DHPRQBPJLMKORJ-XRNKAMNCSA-N
InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31)/t7?,8-,15-,21-,22-/m0/s1
Yes
Bactericide, Fungicide, Antimicrobial
Wood preservative
Amide pesticide; Tetracycline compound
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Natural
Protein synthesis inhibitor
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57-62-5
200-341-7
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006301
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QD06AA52
Dermatologicals: Antibiotics & chemotherapeutics for dermatological use
No
Allowed substance (Table 1: All food producing species)
478.88
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(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
7-chlorotetracycline
Possible groundwater contaminant
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Aurofac Granular 100mg/g premix medicated feed
Alpharma Animal Health
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Animedazon Spray
aniMedica GmbH
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Spimetryl Cutaneous Powder
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Chlorsol 50% Powder for Oral Solution
Vetoquinol UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in formualtions for oral administration
630
R4 R = Peer reviewed scientific publications 4 = Verified data
High
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168.5
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2.40 X 10-01
Calculated
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-0.62
Low
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4.5
R4 R = Peer reviewed scientific publications 4 = Verified data
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2.09 X 10-23
R4 R = Peer reviewed scientific publications 4 = Verified data
Low volatility
4.8 X 10-22
R4 R = Peer reviewed scientific publications 4 = Verified data
Non-volatile
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30
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Moderately persistent
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General literature DT₅₀ range >30 days (R3)
44% lost after 30 days
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Soil and poultry manure at 30°C decreases with decreasing temp
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Soil adsorption and mobility
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Low risk
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Based on LogP < 3
Low risk
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None
Terrestrial ecotoxicology
> 1500
Mouse
Moderate
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> 0.89
R4 R = Peer reviewed scientific publications 4 = Verified data
Unknown species
Moderate
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128
Daphnia magna
Low
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1.62
Lemna gibba
Moderate
3.1
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Pseudokirchneriella subcapitata
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 1500
Mouse
Moderate
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Intraperitoneal LDLo = 335 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 118 mg kg⁻¹
Rat
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Mainly eliminated in the faeces
R4 R = Peer reviewed scientific publications 4 = Verified data
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
XNo, known not to cause a problem
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
No further information available
No information available
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NL (Not listed)
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chlortetracycline
chlortetracycline
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clortetraciclina
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Record last updated:
29/03/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242