Amoxicillin
Last updated: 30/08/2023
(Also known as: amoxycillin; amopen; amoxycillin trihydrate; p-hydroxyampicillin; AMC)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
A broad spectrum semisynthetic a beta-lactam antibiotic / antimicrobial with applications in veterinary medicine
Current
-
Birds, Domestic fowl, Cats, Dogs, Pigs
Isomeric
C₁₆H₁₉N₃O₅S
CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)C(=O)O)C
LSQZJLSUYDQPKJ-NJBDSQKTSA-N
InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
Sodium salt
Variant
Antibacterial, Antibiotic, Medicinal drug
Penicillin related
-
-
Semi-synthetic
Inhibits the synthesis of bacterial cell walls
[Penicillin-binding proteins 1A/1B, antagonist]
26787-78-0
248-003-8
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33613
QJ01CR02; QG51AX01
Antiinfectants for systemic use: Antibacterials for systemic use; Genito urinary system & sex hormones: Antiinfectants & antiseptics for intrautarine use
No
Allowed substance (Table 1: All food producing species)
365.40
-
(2S,5R,6R)- 6-([(2R)-2-amino-2-(4-hydroxyphenyl)-acetyl]amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
D-(-)-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7 -oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid
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-
White crystalline solid
Amoxicure 30% powder for oral solution
Oropharma N.V.
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Amoxival Vet Tablets
Sogeval S.A.
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Synulox Palatable Tablets 50mg
Pfizer ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Betamox 200mg Palatable Tablets
Norbook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Ingested, available as capsules, tablets, chewable tablets and powders/tablets for aqueous suspension
3430
High
7500
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Methanol
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3400
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Ethanol
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194
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-
-
-
-
-
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7.41 X 1000
Calculated
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0.87
Low
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-
-
-
-
-
-
-
-
-
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6.24 X 10-12
Low volatility
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In ethanol: 230nm = 10850, 274nm = 1400 In acid: 229nm = 9500, 272nm = 1080
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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-
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0.23
R4 R = Peer reviewed scientific publications 4 = Verified data
Non-persistent
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-
-
-
-
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General literature gives DT₅₀ 0.16-0.29 days, very rapid
4
R4 R = Peer reviewed scientific publications 4 = Verified data
Manure
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Soil adsorption and mobility
-
R4 R = Peer reviewed scientific publications 4 = Verified data
Slightly mobile
866
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-0.68
Calculated
Low leachability
-
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-
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-
None
Terrestrial ecotoxicology
> 15000
Rat
Low
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-
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> 300
R4 R = Peer reviewed scientific publications 4 = Verified data
Oncorhynchus mykiss
Low
-
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-
101.6
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Low
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
> 1000
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Lemna gibba LOEC
Low
0.037
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Microcystis aeruginosa
Moderate
250
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Selenastrum capricornutum
Low
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-
-
-
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-
HUMAN HEALTH AND PROTECTION
High (class III)
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> 15000
Rat
Low
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Intraperitoneal LD₅₀ = 2870 mg kg⁻¹
rat
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Subcutaneous LD₅₀ > 8000 mg kg⁻¹
Rat
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Rapidly absorbed by the gastrointestinal tract after oral administration, whilst some is metabolised, it is rapidly mostly unchanged in the urine
-
Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause vomiting, rashes and antibiotic-associated colitis May cause allergic or asthmatic symptoms or breathing difficulties if inhaled
Not regulated under IMDG
-
Not listed (Not listed)
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amoxicillin
amoxicilline
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amoxicilina
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Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242