Apramycin
Last updated: 31/08/2023
(Also known as: nebramycin II)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
An antibiotic and antibacterial compound used in veterinary medicine including the treatment of colibacillosis and salmonella in calves and bacterial enteritis in pigs and lambs
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Pigs, Lambs, Cattle, Chickens
Isomeric
C₂₁H₄₁N₅O₁₁
CNC1C(C2C(CC(C(O2)OC3C(CC(C(C3O)O)N)N)N)OC1OC4C(C(C(C(O4)CO)N)O)O)O
CN[C@H]1[C@H]([C@@H]2[C@H](C[C@H]([C@H](O2)O[C@@H]3[C@H](C[C@H]([C@@H]([C@H]3O)O)N)N)N)O[C@@H]1O[C@@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)N)O)O)O
XZNUGFQTQHRASN-XQENGBIVSA-N
InChI=1S/C21H41N5O11/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31/h5-21,26-32H,2-4,22-25H2,1H3/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-/m1/s1
Yes
Antibiotic, Antimicrobial, Antibacterial
Aminoglycoside
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Synthetic
Inhibitor of protein synthesis in bacteria both in vivo and in vitro
[16S rRNA]
37321-09-8
253-460-1
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3081545
QJ51GB90; QA07AA92; QJ01GB90
Antiinfectants for systemic use: Antibacterials for intramammary use; Alimentary tract & metabolism: Intestinal antiinfectants; Antiinfectants for systemic use: Antibacterials for systemic use
No
Allowed substance (Table 1: Bovine, Ovine, Pocine, Chicken, Rabbit)
539.58
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(2R,3R,4S,5S,6S)-2-[[(2R,3S,4R,4αR,6S,7R,8αS)-7-amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy-4-hydroxy-3-(methylamino)-2,3,4,4α,6,7,8,8α-octahydropyrano[3,2-β]pyran-2-yl]oxy]-5-amino-6-(hydroxymethyl)oxane-3,4-diol
D-Streptamine,O-4-amino-4-deoxy-a-D-glucopyranosyl-(1®8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-a-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1®4)-2-deoxy-
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Colourless, needle-shaped crystals
Apralan Soluble Powder for Oral Solution
Eli Lilly Company
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Apralan G200 Premix medicated feeding stuff
Eli Lilly Company
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Often supplied as a powder which is added to livestock's drinking water. Also available as premix and pour-on formulations
300000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
High
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189
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823
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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451.6
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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5.01 X 10-04
Calculated
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-3.3
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Low
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1.56
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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8.5
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Soil adsorption and mobility
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E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Non-mobile
500755
Literature values Koc range 341900 - 659609 mL g⁻¹
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None
Terrestrial ecotoxicology
> 4160
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source
Rat as the sulphate
Low
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1669
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Colinus virginianus
Moderate
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> 100
R4 R = Peer reviewed scientific publications 4 = Verified data
Eisenia foetida
Low
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300
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Oncorhynchus mykiss
Low
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101.6
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Daphnia magna
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 4160
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source
Rat as the sulphate
Low
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Intravenous LD₅₀ = 280 mg kg⁻¹
Mouse
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Apramycin is rapidly absorbed when administered orally and is excreted via the kidneys without metabolisation
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Possible kidney toxicant
When heated to decomposition it emits acrid smoke and irritating fumes Corrosive
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Not listed (Not listed)
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apramycin
apramycine
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apramicina
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Record last updated:
31/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242