The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Environmental fate High alert: Potential for particle bound transport: High
Warning: Significant data are missing
Ecotoxicity High alert: Fish acute ecotoxicity: High; Fish chronic ecotoxicity: High; Daphnia acute ecotoxicity: High
Human health Moderate alert: Mammals acute toxicity: Moderate
Warning: Significant data are missing
GENERAL INFORMATION
Description
A semi-synthetic, broad spectrum veterinary antiparasitic treatment used for the prevention and control of heartworm and intestinal worms in treatments animals such as dogs, cats, horses, cattle and sheep.
Availability status
-
Introduction & key dates
1990, synthesised
Examples of species treated
Domestic pets, Horses, Cattle, Sheep
Chemical structure
Isomerism
Moxidectin is the 23-E isomer of the 23-methoxime derivative of nemadectin
Majority of dose is excreted in faeces. Also identified in milk. The depletion half-lives in fat, muscle and kidney/liver were 11.5, 3.9 and 2.4 days, respectively.
V4 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 4 = Verified data
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
;
B0 B = DNA damage/repair (EFSA database) 0 = No data
;
C0 C = Gene mutation (EFSA database) 0 = No data
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242