Oxfendazole (Ref: HOE 8105)
Last updated: 23/04/2021
(Also known as: OFDZ)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A broad spectrum banthelmintic used against roundworms, strongyles and pinworms for a range of livestock.
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Sheep, Cattle, Goats and Pigs
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C₁₅H₁₃N₃O₃S
COC(=O)NC1=NC2=C(N1)C=C(C=C2)S(=O)C3=CC=CC=C3
No data
BEZZFPOZAYTVHN-UHFFFAOYSA-N
InChI=1s/C15H13N3O3S/c1-21-15(19)18-14-16-12-8-7-11(9-13(12)17-14)22(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
Yes
Anthelmintic, Antiparasitic
Benzimidazole
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Synthetic
Inhibits tubulin synthesis in the parasite and leading to death by starvation.
[Tubulin beta chain, antagonist]
53716-50-0
258-714-5
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QP52AC02
Antiparasitic products, insecticides & repellents: Anthelmintics
No
Allowed substance (Table 1: Ruminants, Porcine, Equidae)
315.35
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(5-(phenylsulfinyl)-1H-benzimidazol-2-yl)carbamic acid methyl ester
methyl-5-(Phenylsulfinyl) benzimidazole-2-carbamate
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White to off-white powder
Autoworm Finisher
Pzifer Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Endoworm Oral Suspension
Norbrook Labs
UK National authorisation (IC)
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Parafend SC oral Ssupension for Sheep
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Autoworm Ready Pulse
Pfizer Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Available in a variety of formulations including pour-ons, drenches and oral suspensions
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253
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4.27 X 1001
Calculated
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1.63
Low
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 6400
Rat
Low
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971
R4 R = Peer reviewed scientific publications 4 = Verified data
Eisenia foetida
Low
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> 2.7
R4 R = Peer reviewed scientific publications 4 = Verified data
Lepomis macrochirus
Moderate
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1.17
Daphnia magna
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 6400
Rat
Low
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Metabolised to active oxfendazole sulfoxide and sulfone. Excreted mainly in faeces.
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E1 E = Unspecified genotoxicity type (miscellaneous data source) 1 = Positive
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
No further information available
No information available
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Not listed (Not listed)
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oxfendazole
oxfendazole
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oxfendazol
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Record last updated:
23/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242