Cyanocobalamin |
![]() Last updated: 30/08/2023 |
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(Also known as: vitamin B12; anacobin) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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Substance used to treat cobalt deficiencies in livestock principally sheep | |
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- | |
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1955 | |
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Sheep, Cattle, Horses, Pigs |
Chemical structure |
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Isomeric | |
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C₆₃H₈₈CoN₁₄O₁₄P | |
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CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3] | |
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CC1=CC2=C(C=C1C)N(C=N2)[C@@H]3[C@@H]([C@@H]([C@H](O3)CO)OP(=O)([O-])O[C@H](C)CNC(=O)CC[C@@]4([C@H]([C@@H]5[C@]6([C@@]([C@@H](/C(=C(/C7=N/C(=C\C8=N/C(=C(\C4=N5)/C)/[C@H](C8(C)C)CCC(=O)N)/[C@H]([C@]7(C)CC(=O)N)CCC(=O)N)\C)/[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3] | |
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FDJOLVPMNUYSCM-WZHZPDAFSA-L | |
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InChI=1S/C62H88N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,57,76,84H,12-19,22,24-27H2,1-11H3,(H2,63,77)(H2,64,78)(H2,65,79)(H2,66,80)(H2,67,81)(H2,68,82)(H,69,83)(H,85,86);;/q;;+1/p-1/b42-23-,54-32-,55-33-;; | |
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Yes |
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Common Name | Relationship | Link |
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cyanocobalamin hydrate | - | ![]() |
General status |
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Medicinal drug | |
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Unclassifed | |
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Natural | |
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Converted to coenzyme B12 that is vital for a number of body processes including growth, hematopoiesis and nucleoprotein and myelin synthesis. | |
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[Methionine synthase], [Methylmalonyl-CoA mutase, mitochondrial], [Methionine synthase reductase, mitochondrial], [Methylmalonic aciduria type A protein, mitochondrial], [Methylmalonic aciduria and homocystinuria type C protein], [Amnionless protein], [Transcobalamin-1], [Transcobalamin-2], [Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial], [Cubilin] | |
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68-19-9 | |
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200-680-0 | |
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166596686 | |
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QB03BA01 | |
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Blood & blood forming organs: Antianemic preparations | |
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No | |
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Not applicable - vitamin | |
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1355.38 | |
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5,6-dimethylbenzimidazolylcobamide cyanide | |
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5,6-dimethyl-benzimidazolyl cyanocobamide | |
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Dark red to brown hygroscopic crystalline solid |
Formulations |
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Duphalyte Solution for injection | Pzifer Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Multivitamin Injection | Norbrook Labs | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Vitbee 250 Solution for injection | Dechra Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Intravit 12 Solution for Injection | Norbrook Labs | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Usually supplied as a solution for injection |
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12500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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102.5 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Decomposes before boiling | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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3.72 X 1003 | Calculated | - | |||||||
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3.57 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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In water max at: 278nm, 361nm & 55nm | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Degradation |
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 5000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 5000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LDLo = 1.36 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ > 2000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Rapidly excreted in the urine and faeces but also identified in human breast milk and bile | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Generally considered to be non-toxic May lead to allergic reactions May cause breathing difficulties |
Handling issues |
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Use water spray, fog or foam to fight fires. Do not use water jet | |||
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Not listed (Not listed) | |||
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cyanocobalamin | ||
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cyanocobalamine | ||
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cianocobalamina | ||
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Record last updated: | 30/08/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |