Dexamethasone
Last updated: 03/03/2022
(Also known as: fluormethylprednisolone)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
Used as an anti-inflammatory drug in a variety of animals including, for example, the control of CNS inflammation in dogs and cats and for the treatment of primary bovine ketosis.
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Cattle, Horses, Lamas, Elephants, Pigs, Dogs, Cats
Isomeric
C₂₂H₂₉FO₅
CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
UREBDLICKHMUKA-CXSFZGCWSA-N
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
dexamethasone
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Anti-inflammatory
Corticosteroid
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Synthetic
Unbound dexamethasone crosses cell membranes and binds to specific cytoplasmic receptors leading to a reduction in inflammation
[Glucocorticoid receptor, agonist], [Nuclear receptor 0B1, stimulator], [Annexin A1, stimulator], [Nitric oxide synthase, inducible, negative modulator]
50-02-2
200-003-9
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QA01AC02; QC05AA09; QD07AB19; QH02AB02; QR01AD03; QS01BA01; QS02BA06; QS03BA01
Alimentary tract & metabolism; Cardiovascular system; Dematologicals; Systemic hormone preparations excluding sex hormones & insulins; Respiratory system; Sensory organs
No
Allowed substance (Table 1 Bovine, Caprine, Porcine, Equidae)
392.46
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8S,9R,10S,11S,13S,14S,16R,17R)-9- fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16- trimethyl-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydro-3H-cyclopenta[a]phenanthren-3-one
1-dehydro-16α-methyl-9α-fluorohydrocortisone
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White crystalline powder
Colvasone 0.2% w/v Solution for injection
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Dexafort suspension for injection
Intervet Uk Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Rapidexon 2 mg/ml solution for injection
Eurovet Animal Health B.V.
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Voren Suspension for Injection 1mg/ml
Boehringer B.V.
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of formulations including injections, creams, sprays and aerosols
89
Moderate
1000
Ethanol
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262
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568
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279.5
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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6.76 X 1001
Calculated
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1.83
Low
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1.32
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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1.18 X 10-08
Low volatility
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Contains chromophores that absorb at wavelengths >290nm
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1.591
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Soil adsorption and mobility
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Moderately mobile
240
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Known soil and groundwater metabolites
None
6-beta-hydroxydexamethasone
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Human (Liver)
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Cytochrome P450 3A4
Terrestrial ecotoxicology
> 3000
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 3000
Rat
Low
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Intraperitoneal LD₅₀ = 54 mg kg⁻¹
Rat
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Subcutaneous LD₅₀ = 14 mg kg⁻¹
Rat
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Metablised and around 30% excreted in the urine within 4 days. Also excreted in human breast milk.
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
?Possibly, status not identified
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause hypertension May cause retinal toxicity, glaucoma & subcapsular cataract May cause delayed wound healing, atrophy & skin fragility
Emits toxic fumes of hydrogen fluoride when heated to decomposition
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None - not a ppp
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dexamethasone
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dexametasona
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Record last updated:
03/03/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242