Carbetocin |
![]() Last updated: 08/04/2021 |
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(Also known as: duratocin; depotocin) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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Synthetic analogue of the posterior pituitary lobe hormone oxytocin which is used to facilitate partutition in a range of animals | |
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Pigs, Cattle, Sheep, Goats |
Chemical structure |
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Isomeric | |
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C₄₅H₆₉N₁₁O₁₂S | |
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CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCCCC(=O)N[C@H](C(=O)N1)CC2=CC=C(C=C2)OC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N | |
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NSTRIRCPWQHTIA-DTRKZRJBSA-N | |
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InChI=1S/C45H69N11O12S/c1-6-25(4)38-44(67)50-28(15-16-34(46)58)40(63)51-30(21-35(47)59)41(64)53-31(23-69-18-8-10-37(61)55(5)33(43(66)54-38)20-26-11-13-27(57)14-12-26)45(68)56-17-7-9-32(56)42(65)52-29(19-24(2)3)39(62)49-22-36(48)60/h11-14,24-25,28-33,38,57H,6-10,15-23H2,1-5H3,(H2,46,58)(H2,47,59)(H2,48,60)(H,49,62)(H,50,67)(H,51,63)(H,52,65)(H,53,64)(H,54,66)/t25-,28-,29-,30-,31-,32-,33-,38-/m0/s1 | |
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Yes |
General status |
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Uterine stimulant, Antihemorrhagic, Synthetic hormone, Oxytocic | |
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Unclassified substance | |
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Synthetic | |
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Binds to oxytocin receptors and stimulates activity | |
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[Oxytocin receptor, agonist] | |
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37025-55-1 | |
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253-312-6 | |
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QH01BB03 | |
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Systemic hormone preparations excluding sex hormones & insulins: Systemic hormonal preparations, excl. sex hormones | |
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No | |
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Allowed substance (Table 1: All mammalian food producing species) | |
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988.16 | |
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(2S)-1-[(3S,6S,9S,12S,15S)-12-[(2S)-butan-2-yl]-9-(2-carbamoylethyl)-6-(carbamoylmethyl)-15-[(4-hydroxyphenyl)methyl]-16-methyl-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carbonyl]-N-[(1S)-1-(ethylcarbamoyl)-3-methyl-butyl]pyrrolidine-2-carboxamide | |
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1-butanoic acid-2-(O-methyl-L-tyrosine)-1-carbaoxytocin | |
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Solid |
Formulations |
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Reprocine 0.07 mg/ml solution for injection for cattle and pigs | VetCom-pharma GmbH | EU Mutually reconised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Degradation |
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Literature quotes DT₅₀ 9.7-26.9 days | ||||||||||
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Soil adsorption and mobility |
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- | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Mobile | |||||||
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43.7 | ||||||||||
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Literature Koc values range 38-56 mL g⁻¹ | ||||||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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> 39.1 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Pseudokirchneriella subcapitata4 = Verified data |
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General |
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Undergoes a biphasic elimination, with a terminal elimination half-life of about 40 minutes. Less than 1% of a dose is excreted unchanged by the kidney. Carbetocin is distributed into breast milk. | Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
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Health issues |
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May cause abdominal pain, anemia, hypotension or tachycardia Causes a range of physiological symptoms |
Handling issues |
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No information available | |||
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None - not a ppp | |||
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carbetocin | ||
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carbetocine | ||
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carbetocino | ||
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Record last updated: | 08/04/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |